Synthesis, crystal structure and Hirshfeld surface analysis of 4'-cyano-[1,1'-biphen-yl]-4-yl 3-(benz-yloxy)benzoate.

In the title compound, CHON, the dihedral angle between the aromatic rings of the biphenyl unit is 38.14 (2)° and the C-O-C-C torsion angle in the benz-yloxy benzene fragment is 179.1 (2)°.

Unravelling the molecular mechanism underlying drought stress tolerance in Dinanath (Pennisetum pedicellatum Trin.) grass via integrated transcriptomic and metabolomic analyses.

Dinanath grass (Pennisetum pedicellatum Trin.) is an extensively grown forage grass known for its significant drought resilience. In order to comprehensively grasp the adaptive mechanism of Dinanath grass in response to water deficient conditions, transcriptomic and metabolomics were applied in the leaves of Dinanath grass exposed to two distinct drought intensities (48-hour and 96-hour).

Biofunctional components and bacterial dynamics of enzymatic and fermentatively prepared rohu () egg sauce.

The present study focused on preparing rohu egg sauce using optimized conditions through enzymatic and fermentative methods. The enzymatic preparation of rohu egg sauce (ERS) involved homogenizing the eggs in water at a ratio of 1:0.9 (w/v), followed by the addition of salt (20% w/w) and papain (3% w/w).

Pyrimidine-triazole-tethered tert-butyl-piperazine-carboxylate suppresses breast cancer by targeting estrogen receptor signaling and β-catenin activation.

Several chemotherapeutics against breast cancer are constrained by their adverse effects and chemoresistance. The development of novel chemotherapeutics to target metastatic breast cancer can bring effective clinical outcomes. Many breast cancer patients present with tumors that are positive for estrogen receptors (ERs), highlighting the importance of targeting the ER pathway in this particular subtype.

A novel class of potent antiangiogenic and antioxidant pyrazoles: synthesis, bioactivity, docking and ADMET studies.

Angiogenesis is the hallmark of cancer progression driven by VEGF/VEGFR-2 signalling pathway, inhibition of which could be a solution to tackle the progression of tumour cells and thus arresting their growth. A novel class of pyrazoles was synthesized using arginine and dibromo ketones. Antiangiogenic activity was performed by yolk sac method.

Thiouracil and triazole conjugate induces autophagy through the downregulation of Wnt/β-catenin signaling pathway in human breast cancer cells.

Autophagy is vital for maintaining cellular homeostasis by breaking down unnecessary organelles and proteins within cells. Its activity varies abnormally in several diseases, including cancer, making it a potential target for therapeutic strategies. The Wnt/β-catenin signaling pathway significantly impacts cancer by stabilizing β-catenin protein and promoting the transcription of its target genes.

Conformational dynamics and ribosomal interactions of Bacillus subtilis Obg in various nucleotide-bound states: Insights from molecular dynamics simulation.

Obg, a GTPase, binds to the premature 50S ribosomal subunit and facilitates recruitment of rproteins and rRNA processing to form the mature 50S subunit. This binding depends on nucleotide-induced conformational changes (GDP/GTP). However, the mechanism by which Obg undergoes conformational changes to associate with the premature 50S subunit is unknown.

Distribution and habitat suitability of the endangered lion-tailed macaque Macaca silenus and other primate species in the Kodagu region of the Western Ghats, India.

Because of the universal decline in biodiversity, it is important to map and assess the populations of the endangered species, especially those endemic to small regions, in their remaining wild habitats. With the main focus on the distribution and habitat suitability of the endangered lion-tailed macaque, Macaca silenus, we carried out a survey on primates in the Kodagu region of the Western Ghats, an area not properly explored earlier. The survey trails covered a length of 523 km.

A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma.

Introduction: Hepatocellular carcinoma (HCC) is a fatal cancer that is often diagnosed at the advanced stages which limits the available therapeutic options. The interaction of HGF with c-MET (a receptor tyrosine kinase) results in the activation of c-MET which subsequently triggers the PI3K/Akt/mTOR axis. Overexpression of c-MET in HCC tissues has been demonstrated to contribute to tumor progression and metastasis.

Ameliorative action of eugenol on nitrate induced reproductive toxicity in male rats.

There is a great concern for studies to prevent nitrate (NO) induced male reproductive toxicity as it might lead to infertility. Therefore, the study was aimed to investigate the ameliorative effects of eugenol on NO induced male reproductive toxicity in wistar rats. Adult male rats were randomly divided into five groups (n=5).

Bioremediation of Brilliant Green cationic dye from water using Nutraceutical Industrial Coriander Seed Spent as an adsorbent: adsorption isotherms, kinetic models, and thermodynamic studies.

The article details a feasibility study of removing Brilliant Green (BG), a mutagenic dye from an aqueous solution by adsorption using low-cost coriander seed spent as a by-product in the nutraceutical industry. The study includes an analysis of the parameters that affect the adsorption process. The variables that have been identified include pH, dye concentration, process temperature, adsorbent amount, and particle size of the adsorbent.

Combining Mitomycin C with inhibition of BAD phosphorylation enhances apoptotic cell death in advanced cervical cancer.

Objective: Mitomycin C (MMC), a DNA-damaging chemotherapeutic, is commonly used clinically for recurrent cervical carcinoma (CC), either alone or in combination. MMC generates DNA damage resulting in CC cell death yet also induces increased AKT-BAD phosphorylation associated with drug resistance and reduced clinical benefit. The present study evaluates the efficacy of combined MMC and a BAD phosphorylation inhibitor in CC.

Probiotic and Functional Attributes of Yeasts Isolated from Different Traditional Fermented Foods and Products.

Though numerous bacteria have been used as probiotics by industries, at present, Saccharomyces boulardii and Saccharomyces cerevesiae are the only yeast probiotics which are industrially exploited. In view of this, yeast probiotics were isolated from traditional fermented foods and products collected from different parts of Karnataka, India. In this work, we have studied the probiotic attributes of ten yeast isolates isolated from different traditionally fermented foods and products.

Insights into the Physicochemical Characteristics and Miscibility of Chitosan/Polypeptide Blends: Promising Material for Wound Healing in Sprague-Dawley Rats.

In this study, the synthesis of poly(AVGVP) [where A-Alanine, V-Valine, G-Glycine, and P-Proline] is executed by the stepwise solution phase method. The interaction between Chitosan and synthetic polypentapeptide in blends was examined in the liquid and solid phases. Viscosity criteria that establish the total miscibility with Chitosan are the Δ[η], the intrinsic viscosity [η], Huggins coefficient [], by Garcia Δ, α by Sun, and μ suggested by Chee, Δ, and β buttressed by Jiang and Han.

Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells.

Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a-hexahydrocyclopenta[e] [1,2]oxazine (FPPO; BSO-07) on JNK-driven apoptosis and paraptosis has been demonstrated in human breast cancer (BC) MDA-MB231 and MCF-7 cells respectively. BSO-07 imparted significant cytotoxicity in BC cells, induced activation of JNK, and increased intracellular reactive oxygen species (ROS) levels.

An enhanced non-enzymatic electrochemical sensor based on the BiS-TiO nanocomposite with HNTs for the individual and simultaneous detection of 4-nitrophenol and nitrofurantoin in environmental samples.

In the current era of rapid population growth, there has been an increase in resource consumption and the subsequent release of organic pollutants into water bodies by various industries. To address this issue, we have developed a nanocomposite material, BiS-TiO/HNTs, for electrochemical sensors capable of simultaneously detecting nitrofurantoin (NFT) and 4-nitrophenol (4-NP) contaminants. The nanocomposite material was synthesized using a novel one-pot sol-gel method, and its structural morphology was characterized using techniques such as FE-SEM, FT-IR, HR-TEM, and XRD.

Measurement invariance of the Facebook intrusion questionnaire across 25 countries.

Facebook is one of the most popular social networking sites. However, Facebook intrusion or addiction is a growing concern as it involves an excessive attachment to Facebook, which disrupts daily functioning. To date, few studies have examined whether cross-cultural differences in the measurement of Facebook addiction exist.

Discovery of oxazine-linked pyrimidine as an inhibitor of breast cancer growth and metastasis by abrogating NF-κB activation.

Introduction: Nuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and piperazine-linked pyrimidines as novel anti-cancer agents that can suppress NF-κB activation in BC cells. Moreover, the TRX-01 compound, an oxazine-linked pyrimidine, inhibited MCF-7 cells at a concentration of 9.

UPLC-ESI MS/MS- and GC-MS-Based Altitudinal Variations in the Bioactive Potential of Mikania micrantha and Ageratum houstonianum.

Traditional medicinal plants have attracted scientific interest due to their bioactive compounds, and the levels of their constituents vary with location and altitude. The present study was designed to evaluate the pharmacological potential of two selected traditional medicinal plants, Mikania micrantha and Ageratum houstonianum collected from two sites, Murlen National Park (MNP) and Dampa Tiger Reserve (DTR), located at different altitudes. Both plant species are used by local traditional healers in Mizoram, Northeast India, to treat various health problems.

A new isoxazolyl-urea derivative induces apoptosis, paraptosis, and ferroptosis by modulating MAPKs in pancreatic cancer cells.

MAPK pathway regulates the major events including cell division, cell death, migration, invasion, and angiogenesis. Small molecules that modulate the MAPK pathway have been demonstrated to impart cytotoxicity in cancer cells. Herein, the synthesis of a new isoxazolyl-urea derivative (QR-4) has been described and its effect on the growth of pancreatic cancer cells has been investigated.

Analysis of miR-497/195 cluster identifies new therapeutic targets in cervical cancer.

Objective: miR-497/195, located at 17p13.1, is a highly conserved miRNA cluster whose abnormal expression is a key regulator of carcinogenesis. We performed a comprehensive analysis of the miR-497/195 cluster to determine its prognostic utility and role in cervical cancer (CC) using publicly available datasets.

Fabrication of rGO-Bridged TiO/g-CN Z-Scheme Nanocomposites via Pulsed Laser Ablation for Efficient Photocatalytic CO Reduction.

Highly efficient photocatalysts can be fabricated using favorable charge transfer nanocomposite channel structures. This study adopted pulsed laser ablation in liquid (PLAL) to obtain rGO-bridged TiO/g-CN (rGO-TiO/g-CN) photocatalytic Z-scheme without the need for noble metals. In addition to evaluating the resulting nanocomposite (comprising rGO nanosheets, TiO nanotubes, and g-CN nanosheets) CO reduction effectiveness, its chemical, morphological, structural, and optical characteristics were examined using various analytical techniques.