Therapeutic management of erectile dysfunction: the AFU/SFMS guidelines.

Context: Erectile dysfunction (ED) is a common sexual disorder. In France, recent evidence-based guidelines are lacking.

Aim: To provide practice guidelines on ED therapeutic management.

Fine-tuning levels of filamins a and b as a specific mechanism sustaining Th2 lymphocyte functions.

Augmenting the portfolio of therapeutics for type 2-driven diseases is crucial to address unmet clinical needs and to design personalized treatment schemes. An attractive therapy for such diseases would consist in targeting the recruitment of T helper 2 (Th2) lymphocytes to inflammatory sites. Herein, we show the degradation of filamins (FLN) a and b by the ASB2α E3 ubiquitin ligase as a mechanism sustaining Th2 lymphocyte functions.

Managing linguistic obstacles in multidisciplinary, multinational, and multilingual research projects.

Environmental challenges are rarely confined to national, disciplinary, or linguistic domains. Convergent solutions require international collaboration and equitable access to new technologies and practices. The ability of international, multidisciplinary and multilingual research teams to work effectively can be challenging.

Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (SAMP).

Background: Several major sensitization profiles have been described in children with asthma, but it remains unclear how these profiles relate to asthma phenotypes. The aim of this study was to determine allergenic sensitization profiles in a megacity cohort (SAMP).

Methods: This was a cross-sectional analysis performed from 2011 to 2015 including preschool and school-age children with severe and moderate asthma from the SAMP cohort.

Comparative bactericidal activity of four macrolides alone and combined with rifampicin or doxycycline against at concentrations achievable in foals.

Introduction: causes life-threatening respiratory disease in foals. The standard treatment typically involves a combination of rifampicin and a macrolide antibiotic. Although previous studies have demonstrated the activity of these antibiotics against , the tested concentrations often do not reflect those achievable in foals.

How difficult is it perceived to takeover in a level 3 automated vehicle? Investigation of the ease of use according to task and situational factors.

One goal of automated driving is to mitigate risks by minimising human intervention. However, widespread acceptance of automated vehicles hinges on their perceived ease of use, particularly during takeover scenarios. This online survey investigates the perceived difficulty of takeover in Level 3 Automated Vehicles, focusing on factors influencing takeover performance such as duration of automated mode and traffic density, as well as Non-Driving-Related Tasks like listening to music or engaging in conversation.

Immune digital twins for complex human pathologies: applications, limitations, and challenges.

Digital twins represent a key technology for precision health. Medical digital twins consist of computational models that represent the health state of individual patients over time, enabling optimal therapeutics and forecasting patient prognosis. Many health conditions involve the immune system, so it is crucial to include its key features when designing medical digital twins.

Digital Outcomes as Biomarkers of Disease Progression in Early Parkinson's Disease: A Systematic Review.

Outcomes derived from digital health technologies (DHTs) are promising candidate markers for monitoring Parkinson's disease (PD) progression. They have the potential to represent a significant shift in clinical research and therapeutic development in PD. However, their ability to track disease progression is yet to be established.

Circulating tumor-reactive KIRCD8 T cells suppress anti-tumor immunity in patients with melanoma.

Effective anti-tumor immunity is driven by cytotoxic CD8 T cells with specificity for tumor antigens. However, the factors that control successful tumor rejection are not well understood. Here we identify a subpopulation of CD8 T cells that are tumor-antigen-specific and can be identified by KIR expression but paradoxically impair anti-tumor immunity in patients with melanoma.

Efficacy and Safety of Nemolizumab in Patients With Moderate to Severe Prurigo Nodularis: The OLYMPIA 1 Randomized Clinical Phase 3 Trial.

Importance: Prurigo nodularis (PN) is a chronic and debilitating skin condition, characterized by intense itch with multiple nodular lesions. Nemolizumab demonstrated significant improvements in itch and skin nodules in adults with moderate to severe PN in a previous 16-week phase 3 study (OLYMPIA 2).

Objective: To assess the efficacy and occurrence of adverse events in adults with moderate to severe PN treated with nemolizumab vs those receiving placebo.

LuLIPLEX: A Fast, Highly Sensitive, and Multiplexed Method for the Detection of IgE Against Major Allergens.

Background: Diagnosis of allergies is mostly based on the patient's clinical history and allergen provocation tests. Determination of specific IgE (sIgE) profiles can be performed to support allergy diagnosis. This is commonly done in vivo by the skin prick test or in vitro with automated systems.

Vancomycin population pharmacokinetic models: Uncovering pharmacodynamic divergence amid clinicobiological resemblance.

Vancomycin is an antibiotic used for severe infections. To ensure microbiological efficacy, a ratio of AUC/MIC ≥400 is recommended. However, there is significant interindividual variability in its pharmacokinetic parameters, necessitating therapeutic drug monitoring to adjust dosing regimens and ensure efficacy while avoiding toxicity.

Monitoring of Ammonium and Nitrate Ions in Soil Using Ion-Sensitive Potentiometric Microsensors.

Focusing on the ChemFET (chemical field-effect transistor) technology, the development of a multi-microsensor platform for soil analysis is described in this work. Thus, different FET-based microdevices (i.e.

French AFU Cancer Committee Guidelines - Update 2024-2026: Upper urinary tract urothelial cancer (UTUC).

Introduction: The purpose of this study was to propose an update of the French guidelines from the national committee ccAFU on upper tract urothelial carcinomas (UTUC).

Methods: A systematic Medline search for epidemiology, risk factors, diagnosis, prognosis, treatment options and follow-up of UTUC was performed between 2022 and 2024 to evaluate available references and their levels of evidence.

Results: UTUC is a rare malignancy with specific risk factors, including exposure to aristolochic acid and Lynch syndrome.

French AFU Cancer Committee Guidelines - Update 2024-2026: Non-muscle invasive bladder cancer (NMIBC).

Objective: To update the CCAFU recommendations for the management of non-muscle invasive bladder cancer (NMIBC).

Methods: A systematic review (Medline) of the literature from 20222024 was performed, taking into account the elements of diagnosis, treatment options and monitoring of NMIBC and evaluating references with their level of evidence.

Results: The diagnosis of NMIBC (Ta, T1, or CIS) is made after complete and deep tumour resection.

French AFU Cancer Committee Guidelines - Update 2024-2026: Muscle-invasive bladder cancer (MIBC).

Objective: To update the CCAFU recommendations for the management of muscle-invasive bladder cancer (MIBC).

Methods: A systematic review (Medline) of the literature from 2022 to 2024 was carried out, taking into account the elements of the diagnosis, the treatment options and the monitoring of NMIBC and MIBC, evaluating the references with their level of evidence.

Results: MIBC is diagosed after the must complete tumor resection possible .

Medium term hydrochemical and CO responses to anthropogenic and environmental changes in karst headwater streams.

This study investigates the intricate effects of lithology, temperature, discharge, and land use changes on headwater stream chemistry by analysing two decades of hydrochemical data from twenty karst headwater catchments in the Garonne River basin, France. Focused on the Pyrenees and the lowland (LM) and upland (UM) regions of the Massif Central, this study identified significant regional variations and commonalities in water chemistry. The headwater streams were clustered based on their hydrological and hydrochemical profiles, revealing strong similarities between upland sites, i.

2q33 Deletions Underlying Syndromic and Non-syndromic CTLA4 Deficiency.

Purpose: CTLA4 deficiency is an inborn error of immunity (IEI) due to heterozygosity for germline loss-of-function variants of the CTLA4 gene located on chromosome 2q33.2. CTLA4 deficiency underlies pleiotropic immune and lymphoproliferation-mediated features with incomplete penetrance.

EEG Spectral Power Changes in Patients With Dysexecutive Syndrome Following Cognitive Intervention.

Background: Acquired brain injury (ABI) leads to cognitive deficiencies, alteration of brain activity associated with an increase in slow-wave (delta and theta bands) power, and reduced fast-wave (alpha, beta, and gamma bands) power. To compensate for the cognitive deficits that impact autonomy and quality of life, patients in a chronic phase can benefit from cognitive intervention.

Objective: This study explores the effects of cognitive intervention on brain activity, measured by electroencephalography (EEG), and on executive functioning, assessed by the Test of Attentional Performance (TAP) battery.

Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective.

Background: The physiopathology of sarcopenia shares common biological cascades with the aging process, as does any other age-related condition. However, our understanding of the interconnected pathways between diagnosed sarcopenia and aging remains limited, lacking sufficient scientific evidence.

Methods: This narrative review aims to gather and describe the current evidence on the relationship between biological aging determinants, commonly referred to as the hallmarks of aging, and diagnosed sarcopenia in humans.

Exploring cryopreservation alternatives for Dirofilaria immitis microfilariae.

Canine Heartworm Disease, caused by Dirofilaria immitis, primarily affects canids and felids. The earliest studies on cryopreservation were carried out at -70°C, achieving acceptable survival rates, however microfilariae (mf) showed alterations both in morphology and motility. Thereafter, liquid nitrogen was used representing an excellent tool for long-term preservation, albeit it is expensive and requires trained personnel.

Effect of vitamin D, omega-3 supplementation, or a home exercise program on muscle mass and sarcopenia: DO-HEALTH trial.

Background: We aimed to investigate the effect of daily supplemental vitamin D, omega-3s, and a thrice-weekly home exercise program, alone or in combination, on change of appendicular lean muscle mass index (ALMI) and incident sarcopenia in older adults.

Methods: This is a secondary endpoint analysis of a 3-year randomized, double-blind, placebo-controlled trial with a 2 × 2 × 2 factorial design among 2157 community-dwelling, healthy adults aged 70 + years, from 2012 to 2018 (DO-HEALTH). Participants were randomized to 2000 IU/d vitamin D and/or 1 g/d marine omega-3s and/or exercise.