Do we feel the same emotions in simulation as with a real patient? A pilot study among dental students.

Introduction: Simulation is an educational tool for developing the technical and nontechnical skills of dental students. To optimize learning in simulations, students must be immersed in a high-fidelity environment and emotionally engaged, as is the case in clinical practice. The primary objective of this study was to assess emotions during simulation training and in clinical practice.

Sickness behaviour and the effect of sex, age, and immune status on individual behavioural variation in Tenebrio molitor.

Sick animals generally behave differently than healthy individuals by, for example, being less active and exploratory. How an individual responds to illness is also likely to be mediated by the individual's age because age will dictate the individual's ability to fight a challenge. To date, empirical research on sickness behaviour has focused on the population-level average effect of ill health on behaviour.

SynPlanner: An End-to-End Tool for Synthesis Planning.

SynPlanner is an end-to-end tool for designing customized retrosynthetic planners from reaction data. It includes a reaction data curation pipeline (reaction atom-to-atom mapping, reaction standardization, and filtration), reaction rule extraction, retrosynthetic model training, and retrosynthetic planning. The tool is designed to be as flexible as possible, supporting the customization of each step of the pipeline to address different needs in the development of customized retrosynthetic planning solutions.

Preoperative CT-Scan Angiography Reconstruction Before Right Colectomy with Complete Mesocolon Excision: A Systematic Review and Meta-analysis.

Background: Complete mesocolon excision (CME) and central vascular ligation for right colonic cancers have been developed to improve oncological outcomes. However, it has been linked with a higher risk of morbidity and technical difficulties in operating near major vessels. This study investigated the impact of preoperative surgical planning utilizing CT reconstruction on surgical outcomes in right colectomy with CME.

The role of microRNA in the regulation of hepatic metabolism and energy-expensive processes in the hibernating dormouse.

The garden dormouse (Eliomys quercinus) is a fat-storing mammal that undergoes annual periods of hibernation to mitigate the effects of food scarcity, low ambient temperatures, and reduced photoperiod that characterize winter. Like other hibernating species, this animal suppresses its metabolic rate by downregulating nonessential genes and processes in order to prolong available energy stores and limit waste accumulation throughout the season. MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that bind to mRNA and mediate post-transcriptional suppression, making miRNA ideal for modulating widespread changes in gene expression, including global downregulation typified by metabolic rate depression.

Nanopore Sequencing as a Cutting-Edge Technology for Medulloblastoma Classification.

Background: Medulloblastoma (MB) is one of the most prevalent embryonal malignant brain tumors. Current classification organizes these tumors into four molecular subgroups (WNT, SHH, Group 3, and Group 4 MB). Recently, a comprehensive classification has been established, identifying numerous subtypes, some of which exhibit a poor prognosis.

Correlation Analysis Between Cortical Structural Features and Acoustic Features in Patients With Parkinson's Disease.

Purpose: Parkinson disease (PD) is a progressive neurodegenerative disease. The aim of this study is to investigate the association between acoustic and cortical brain features in Parkinson's disease patients.

Methods: We recruited 19 (eight females, 11 males) Parkinson's disease patients and 19 (eight females, 11 males) healthy subjects to participate in the experiment.

FBG-driven simulation for virtual augmentation of fluoroscopic images during endovascular interventions.

Endovascular interventions are procedures designed to diagnose and treat vascular diseases, using catheters to navigate inside arteries and veins. Thanks to their minimal invasiveness, they offer many benefits, such as reduced pain and hospital stays, but also present many challenges for clinicians, as they require specialized training and heavy use of X-rays. This is particularly relevant when accessing (i.

Impact of Side Chain Chemical Structure on Doping and Thermoelectric Properties of Oriented PBTTT Thin Films.

In this contribution, doping of oriented thin films is investigated for three PBTTT polymers bearing different side chains including linear alkyl ─(CH)─H, single ether ─(CH)─O─(CH)─H and alkyl-siloxane ─(CH)─(Si(CH)O)─Si(CH) A combination of transmission electron microscopy, polarized UV-vis-NIR spectroscopy and transport measurements helps uncover the essential role of the chemical nature of side chains on the efficacy of the doping and on the resulting thermoelectric performances in oriented PBTTT films. Siloxane side chains help to reach record alignment level of PBTTT with dichroic ratio beyond 50 for an optimized rubbing temperature but they impede effective doping of PBTTT crystals with FTCNNQ, resulting in very poor TE properties. By contrast, doping the amorphous phase of all three PBTTTs with magic blue (MB) results in excellent TE performances.

Impact of surface chemistry of upconversion nanoparticles on time-dependent cytotoxicity in non-cancerous epithelial cells.

The application of upconversion nanoparticles (UCNPs) for cell and tissue analysis requires a comprehensive understanding of their interactions with biological entities to prevent toxicity or harmful effects. Whereas most studies focus on cancer cells, this work addresses non-cancerous cells with their regular in vitro physiology. Since it is generally accepted that surface chemistry largely determines biocompatibility in general and uptake of nanomaterials in particular, two bilayer surface coatings with different surface shielding properties have been studied: (i) a phospholipid bilayer membrane (PLM) and (ii) an amphiphilic polymer (AP).

Long-Term Clinical and Biological Prognostic Factors of Anti-NMDA Receptor Encephalitis in Children.

Background And Objectives: Anti-NMDAR encephalitis (NMDARE) is a severe neurologic condition, and recently, the NMDAR Encephalitis One-Year Functional Status (NEOS) score has emerged as a 1-year prognostic tool. This study aimed to evaluate NEOS score and biomarker (neurofilament light chains [NfL], total-Tau protein, glial fibrillary acidic protein, and serum cytokines) correlation with modified Rankin Scale (mRS), cognitive impairment, and clinical recovery in pediatric NMDARE over 2 years.

Methods: In this French multicenter observational study, 104 pediatric patients with NMDARE were followed for a minimum of 2 years.

Entanglement Generation in Weakly Driven Arrays of Multilevel Atoms via Dipolar Interactions.

We investigate the driven-dissipative dynamics of multilevel atomic arrays interacting via dipolar interactions at subwavelength spacings. Unlike two-level atoms in the weakly excited regime, multilevel atoms can become strongly entangled. The entanglement manifests as the growth of spin waves in the ground-state manifold and survives after turning off the drive.

Organ-specific response to [Lu]DOTATATE peptide receptor radionuclide therapy (PRRT) assessed by sequential [Ga]DOTATOC PET/CT in patients with metastatic small intestine neuroendocrine tumors.

Purpose: To evaluate organ-specific response to [Lu]DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) in patients with small intestine neuroendocrine tumor (SiNET) through [Ga]DOTATOC PET/CT, and to analyze tumor uptake and functional volume variations at different metastatic sites in relation to disease progression during clinical follow-up after treatment.

Methods: A retrospective analysis was conducted on 33 metastatic patients. PET/CT were performed pre-treatment (PET0), mid-treatment after two PRRT cycles (PET2), and post-treatment (PET4).

Optimal dosage regimens of cefiderocol administered by short, prolonged or continuous infusion: a PK/PD simulation study.

Background And Objectives: Cefiderocol approved dosages are based on a prolonged infusion (PI) of 3 h that may not be adequate in all settings The objective of this study was to identify alternative cefiderocol dosage regimens based on short infusion (SI) or continuous infusion (CI).

Methods: We performed 1000-patient pharmacokinetic/pharmacodynamic (PK/PD) simulations based on a reference population model. Drug penetration into the epithelial lining fluid (ELF) was considered for pneumonia.

Creativity gain or drain: The dual association between boundary-spanning and creativity.

Boundary-spanning behavior, which involves building relationships with external entities to achieve organizational goals, has been highlighted as a key mechanism for enhancing the inflow of external knowledge. While boundary-spanning can fuel creativity by providing employees with new resources, ideas, and inspiration, it also poses challenges, potentially depleting resources and inducing stress that hinders creativity. Drawing on Conservation of Resources (COR) Theory, this paper explores the dual impact of boundary-spanning on employee creativity-serving both as a facilitator and inhibitor.

SurgiTrack: Fine-grained multi-class multi-tool tracking in surgical videos.

Accurate tool tracking is essential for the success of computer-assisted intervention. Previous efforts often modeled tool trajectories rigidly, overlooking the dynamic nature of surgical procedures, especially tracking scenarios like out-of-body and out-of-camera views. Addressing this limitation, the new CholecTrack20 dataset provides detailed labels that account for multiple tool trajectories in three perspectives: (1) intraoperative, (2) intracorporeal, and (3) visibility, representing the different types of temporal duration of tool tracks.

Organic compounds in valley fogwater in North and Mount Lebanon during COVID-19 period.

Caltech Active Strand Cloudwater collectors are used to collect valley fog samples from Mount and North-Lebanon during 2021 for the speciation of organic matter for the first time ever. Numerous compounds including pesticides, phenols, acids, and persistent organic pollutants such as polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and polycyclic aromatic hydrocarbons (PAHs) have been identified in fogwater samples. They are extracted using the liquid-liquid extraction performed on the XTR chromabond columns.

Is it the right time to promote competency-based European Training Requirements in Ophthalmology? A European Board of Ophthalmology survey.

Purpose: To report national practices and recent progress in competency-based medical education (CBME) implementation in ophthalmology across European countries.

Methods: A 30-question online survey was emailed to European Union of Medical Specialists (UEMS) ophthalmology section delegates, European Board of Ophthalmology Diploma (EBOD) examiners and presidents of ophthalmology societies affiliated with UEMS/EBO.

Results: A total of 230 ophthalmologists with an average age of 54.

Neuromuscular Fatigue in Hamstring and Quadriceps Muscles Following Simulated Soccer Match-Play and Typical Training Sessions.

Purpose: This study investigated the mechanisms of neuromuscular fatigue and recovery in quadriceps and hamstring muscles following soccer match-play and typical training sessions dedicated to the physical development of players.

Methods: Fifteen male professional academy soccer players completed at different visits a 90-minute simulated soccer match-play (MATCH) and four training sessions modulating the metabolic nature (HIIT vs. SPRINT) and the mechanical load (number of changes of direction [COD]).

Performance of the Bioline™ Malaria Ag Pf/Pan and Bioline™ Malaria Ag Pf/Pv for Malaria Diagnostics: Madagascar In-Country Evaluation.

Malaria remains a significant public health concern in Madagascar. The WHO recommends using parasitological methods to confirm Plasmodium infection before treatment. This study evaluated the performance of two rapid diagnostic tests (RDTs), Bioline™ Malaria Ag Pf/Pan (Abbott Point of Care, Princeton, NJ) and Bioline™ Malaria Ag Pf/Pv (Abbott Point of Care, Princeton, NJ), compared with microscopy and polymerase chain reaction (PCR) as reference methods.

Design and 3D printing of pelvis phantoms for cementoplasty.

Background: Percutaneous image-guided cementoplasty is a medical procedure for strengthening bones structurally altered by disease, such as osteolytic metastasis. This procedure involves injecting biocompatible liquid bone cement, through one or more trocars into the damaged bone. Within a few minutes the bone cement hardens and restores the rigidity of the bony structure.

Watching lanthanide nanoparticles one at a time: characterization of their photoluminescence dynamics at the single nanoparticle level.

Lanthanide nanoparticles (LnNPs) feature sharp emission lines together with millisecond emission lifetimes which make them promising luminescent probes for biosensing and bioimaging. Although LnNPs are attracting much interest, their photoluminescence properties at the single nanoparticle level remain largely unexplored. Here, we employ fluorescence correlation spectroscopy (FCS) and photoluminescence burst analysis to investigate the photodynamics of Sm- and Eu-based LnNPs with single nanoparticle sensitivity and microsecond resolution.

Dental Health in Children with Congenital Heart Defects: A Systematic Review and Meta-Analysis.

Oral health outcomes in children with Congenital Heart Defects (CHD) have significant implications. The aim of this systematic review and meta-analysis is to update the current understanding of oral health outcomes in children with CHD and compare caries prevalence between CHD children and healthy controls. All studies between 2014 and 2024 comparing oral health status between children with and without CHD were considered for inclusion.

Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study.

Background And Hypothesis: Cardiovascular diseases are a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Acute kidney injury (AKI) has been increasingly recognized as a potential exacerbating factor for cardiovascular events in these patients. The CKD-REIN study aims to explore the relationship between AKI and the risk of major adverse cardiovascular events (MACE) in a cohort of CKD patients.

Central nervous system complications of immune checkpoint inhibitors: A comprehensive review.

The ever-increasing use of immune checkpoint inhibitors (ICIs) has significantly improved cancer management, but at the cost of frequent immunologic side effects. Among them, neurologic immune-related adverse events (nirAEs) are less common but pose a challenge to clinicians due to their severity, heterogeneous nature and nonspecific clinical presentation, making diagnosis complex. The prognosis of these nirAEs, especially those related to the central nervous system (CNS), correlates with their rapid recognition and therapeutic management.