Plasticity of enteric neurotransmission varies during day-night cycles and with feeding state.

The circadian cycle is a fundamental biological rhythm that governs many physiological functions across nearly all living organisms. In the gastrointestinal tract, activities such as gut motility, hormone synthesis, and communication between the gut, central nervous system and microbiome all fluctuate in alignment with the circadian cycle. The enteric nervous system (ENS) is critical for co-ordinating many of these activities, however, how its activity is governed by the circadian cycle remains unknown.