[p53 gene intron 7 polymorphism and its association with oral neoplasms].

Objective: To investigate the association between oral neoplasm genetic susceptibility and genetic polymorphism of p53 intron 7.

Methods: The intron 7 ApaI polymorphism of p53 was analyzed in 95 oral neoplasm patients and 105 healthy individuals by utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping assay technique, and direct sequencing was performed in 30 cases which were selected from the patients and controls by random sampling.

Results: In oral neoplasms cases, haplotype combinations were T-G 43.