999 results match your criteria: "the University of Florida[Affiliation]"
N Engl J Med
January 2025
From the University of Florida College of Medicine, Jacksonville (D.J.A.); and Azienda Ospedaliero-Universitaria Policlinico "Gaspare Rodolico-San Marco, " University of Catania, Catania, Italy (D.C.).
Carotid artery atherosclerotic stenosis is an important annual cause of stroke in the United States. Moreover, the incidence of carotid artery stenosis is significantly increasing due to the widespread popularity of high fat and high salt diets, sedentary lifestyles, and the increasing age of the population. Of major importance to cardiovascular specialists is the fact that individuals with atherosclerotic carotid artery stenosis can have a prevalence of atherosclerotic coronary artery disease as high as 50 to 75%.
View Article and Find Full Text PDFJAAPA
February 2025
In the PA program at the University of Florida in Gainesville, Fla., Elizabeth Brownlee is director of didactic education and Melissa Turley is interim program director and a clinical assistant professor. Heather Nations practices in obstetrics and gynecology at UF Health Physicians in Gainesville. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Chimeric antigen receptor (CAR) T-cell therapy has led to significant advances in the treatment of blood cancers such as leukemia, lymphoma, and multiple myeloma, and now shows promise for solid tumors. This type of immunotherapy can achieve high response rates in patients with hematologic malignancies, but carries serious adverse reactions, including cytokine release syndrome and immune-effector cell-associated neurotoxicity syndrome. This article describes CAR T-cell therapy, guidance for primary care providers caring for patients undergoing therapy, and the ongoing need for research to enhance CAR T-cell therapy's safety and effectiveness.
View Article and Find Full Text PDFHealth Aff (Millwood)
January 2025
Bakhtawar Ahmad is a postdoctoral research scholar at the University of Florida, in Gainesville, Florida. The patient's name and certain identifying details have been changed in this essay to protect their privacy. The author is very grateful to the patients' families that allowed for sharing of their stories. She is also very grateful to Carolina Maciel, Katharina Busl, and Daniela Pomar-Forero at the University of Florida for their valuable review of and feedback on the article. She acknowledges the Gorman family for their support of the research endeavors at the University of Florida. To access the author's disclosures, click on the Details tab of the article online.
A disturbing encounter causes a new doctor to question the integrity of the informed consent process in a hospital abroad.
View Article and Find Full Text PDFClin Transl Oncol
December 2024
Lillian S Wells Department of Neurosurgery at the University of Florida: University of Florida Lillian S Wells Department of Neurosurgery, Gainesville, FL, USA.
Glioblastoma (GBM) is one of the most common primary malignant brain tumors. Annually, there are about six instances recorded per 100,000 inhabitants. Treatment for GB has not advanced all that much.
View Article and Find Full Text PDFProc (Bayl Univ Med Cent)
October 2024
Department of Gastroenterology and Hepatology, The University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.
Background: Endoscopic bariatric interventions are viable alternatives to traditional weight loss surgeries for patients with a body mass index between 30 and 40 kg/m. While studies have explored the impact of intragastric balloons on obesity and weight reduction, comprehensive data on real-world device-related complications and failures are limited. This study aimed to investigate mechanical failures leading to patient adverse events reported to the US Food and Drug Administration.
View Article and Find Full Text PDFJACC Case Rep
November 2024
Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.
A 73-year-old man with atrial fibrillation and coronary disease requiring stenting to the right coronary artery 7 months prior was admitted for observation after taking an extra dofetilide dose. Troponins trended upward, and electrocardiogram demonstrated QT prolongation to 502 ms as well as T-wave inversions. The patient underwent cardiac catheterization, which revealed severe distal left main disease.
View Article and Find Full Text PDFLancet Gastroenterol Hepatol
January 2025
Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY, USA. Electronic address:
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a public health threat as it affects approximately 38% of the adult population worldwide, with its prevalence rising in step with that of obesity and type 2 diabetes. Beyond the implications of MASLD for liver health, it is also associated with cardiovascular and vascular dysfunction. Although the many shared risk factors and common metabolic milieu might indicate that cardiovascular disease and MASLD are discrete outcomes from common systemic pathogeneses, a growing body of evidence has identified a potential causal relationship between MASLD and coronary artery disease, which is the leading cause of morbidity and mortality in people with MASLD and all-cause mortality worldwide.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
Biomolecular NMR Laboratory, Division of Genetics and Cell Biology c/o IRCCS Ospedale San Raffaele Via Olgettina 58, 20132 Milan, Italy.
Histone methyltransferase NSD2 (MMSET) overexpression in multiple myeloma (MM) patients plays an important role in the development of this disease subtype. Through the expansion of transcriptional activating H3K36me2 and the suppression of repressive H3K27me3 marks, NSD2 activates an aberrant set of genes that contribute to myeloma growth, adhesive and invasive activities. NSD2 transcriptional activity also depends on its non-catalytic domains, which facilitate its recruitment to chromatin through histone binding.
View Article and Find Full Text PDFCancers (Basel)
October 2024
Department of Individualized Cancer Management, Moffitt Cancer Center, Tampa, FL 33612, USA.
In the original publication [...
View Article and Find Full Text PDFJ Vet Med Educ
August 2024
University of Florida, College of Veterinary Medicine, 2015 S.W. 16th Avenue, Post Office Box 100116, Gainesville, FL 32610, USA.
The COVID-19 pandemic provided insight into the gaps provided by health care systems that could benefit from collaborative practice across the nexus of the animal and human health professions. The platform of Interprofessional Education (IPE), recognized as a pedagogical platform for delivering the principles of One Health, embodies the benefits of collaboration to address critical emerging public health issues, including the emergence of vector-borne zoonoses, antimicrobial resistance, food security and defense and the impacts of climatic change. A phenomenological methodology, which is used to understand individuals lived experience, elicited veterinary students' perceptions of the benefits of interprofessional learning.
View Article and Find Full Text PDFJ Am Board Fam Med
October 2024
From the University of Florida Health Jacksonville, Jacksonville, FL (AK, SG, BS, AT), University of Florida College of Medicine, Gainesville, FL (RS, GH).
PNAS Nexus
October 2024
Department of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.
Converging lines of preclinical and clinical research indicate that females, in stark contrast to males, display an increased prevalence of chronic pain. Females also demonstrate weaker analgesic efficacy in response to opioid therapies when compared with males. These sex-specific differences may be driven by dimorphic endogenous opioidergic responses.
View Article and Find Full Text PDFPEC Innov
December 2024
Lineberger Cancer Center, University of North Carolina, USA.
Am J Ophthalmol Case Rep
December 2024
The University of Florida, Department of Ophthalmology, 1600 SW Archer Road, Gainesville, FL, 32608, USA.
Surg Oncol
October 2024
Department of Surgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:
Introduction: For retroperitoneal sarcomas (RPS), aggressive surgical resection offers the only chance for a cure; however, 5-year survival remains below 65%. Therefore, there is a critical need to identify drivers of poor clinical outcomes.
Materials And Methods: To identify biomarkers of tumors likely to recur following curative intent resection, we performed genomic and transcriptomic sequencing for 47 and 34 patients, respectively, with non-metastatic RPS at a single, high-volume sarcoma center.
J Dent
October 2024
Department of Clinical and Community Sciences, School of Dentistry, University of Alabama at Birmingham, Room SDB 109, 1720 Second Avenue South, Birmingham, AL 35294-0007, USA.
JHEP Rep
July 2024
The Global NASH Council, Washington DC, USA.
Background & Aims: Patients with nonalcoholic fatty liver disease (NAFLD)/metabolic dysfunction-associated steatotic liver disease (MASLD) face a multifaceted disease burden which includes impaired health-related quality of life (HRQL) and potential stigmatization. We aimed to assess the burden of liver disease in patients with NAFLD and the relationship between experience of stigma and HRQL.
Methods: Members of the Global NASH Council created a survey about disease burden in NAFLD.
Hous Stud
September 2022
Grounded Solutions Network, where he leads the effort of tracking the scope, trends, and impacts of inclusionary housing and shared equity homeownership programs. Previously, Vince worked at the Shimberg Center for Housing Studies at the University of Florida, where he received a master's and doctorate in urban and regional planning.
Ann Hepatol
June 2024
Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University, Düsseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:
J Hepatol
July 2024
Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University, Düsseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:
J Pediatr Pharmacol Ther
June 2024
Department of Pharmacy (KV, PHP, KJ, CJ, NF, AP), AdventHealth for Children, Orlando, FL. NF was a pharmacy student at the University of Florida College of Pharmacy at the time of this study.
Objectives: Urinary tract infection (UTI) is the most common bacterial infection in infants. Current practice guidelines suggest a treatment duration of 7 to 14 days. Suboptimal therapy may increase the risk for recurrent UTIs leading to renal scarring and possibly chronic kidney disease.
View Article and Find Full Text PDFCureus
May 2024
Pediatrics, University of Florida College of Medicine, Gainesville, USA.
Introduction Propofol is a phenol agent with sedative and anesthetic properties that has been in use for decades, but with controversy in critically ill pediatric patients, given the concern for developing propofol-related infusion syndrome (PRIS). Our aim was to assess the risk of propofol infusions in the pediatric intensive care unit (PICU) at doses and durations greater than the described safety data and its associated covariables. Methods Retrospective cohort analysis of 173 patients receiving propofol in the PICU.
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