1,503 results match your criteria: "the University of Cincinnati[Affiliation]"

Article Synopsis
  • The study investigates the agreement and consistency between parent and child reports of symptoms in children with eosinophilic esophagitis (EoE), a condition affecting the esophagus.
  • Using data from 292 parent-child pairs over five years, the researchers found strong correlation in symptom reports between parents and children, indicating that both perspectives are aligned and reliable.
  • Results showed that while parent-reported quality of life scores remained stable, child reports improved over time, with younger children showing greater discrepancies between parent and child assessments, especially in psychosocial areas.
View Article and Find Full Text PDF

Opportunities and Obstacles: The Impact of COVID-19 on Student Registered Nurse Anesthetists.

AANA J

August 2024

is the CEO of the American Association of Nurse Anesthesiology (AANA) Foundation and is the Chief Advocacy Officer at the American Association of Nurse Anesthesiology, Rosemont, Illinois. Email:

Article Synopsis
  • - The COVID-19 pandemic, declared in March 2020, significantly affected nurse anesthesia education, leading to feelings of isolation, anxiety, and stress among student registered nurse anesthetists (SRNAs).
  • - A positive financial aspect emerged for some SRNAs, with nearly half receiving federal stimulus funds, which helped alleviate some financial pressures.
  • - Educational delivery shifted dramatically, with a notable increase in distance education and virtual simulation, fundamentally changing how SRNAs learned during the pandemic.
View Article and Find Full Text PDF

Quality of life and psychological issues associated with food allergy.

J Food Allergy

December 2023

From the Bernstein Allergy Group Inc, Cincinnati, Ohio, and.

Food allergies (FA) pose risks beyond just the physical harm caused by anaphylaxis. The psychological consequences associated with an FA diagnosis can arguably be more detrimental for long-term health and quality of life than the consequences of an actual reaction. This can be seen in the hypervigilance of patients and caregivers surrounding mealtime, limited social interactions with peers, strained familial relationships, and increased reluctance to travel.

View Article and Find Full Text PDF

Using oral food challenges to provide clarity and confidence when diagnosing food allergies.

J Food Allergy

April 2021

From the Bernstein Allergy Group, Inc, Cincinnati, Ohio, and.

A verified food allergy can be an impactful life event that leads to increased anxiety and measurable effects on quality of life. Allergists play a key role in framing this discussion and can help alleviate underlying fears by promoting confidence and clarifying safety concerns. Correctly diagnosing a patient with an immunoglobulin E (IgE) mediated food allergy remains a nuanced process fraught with the potential for error and confusion.

View Article and Find Full Text PDF

Optimal patient selection for oral immunotherapy.

J Food Allergy

July 2022

From the Bernstein Allergy Group Inc., Cincinnati, Ohio; and.

Standard criteria for ideal patient selection with food oral immunotherapy (OIT) have yet to be determined. Although there are a handful of contraindications to consider before recommending OIT, most patients with confirmed immunoglobulin E-mediated food allergies are appropriate candidates. Success rates of OIT can vary widely and be influenced by several factors.

View Article and Find Full Text PDF

We extended a mechanistic, physics-based framework of the dry down process, previously developed for liquids and electrolytes, to solids and coded it into the latest UB/UC/P&G skin permeation model, herein renamed DigiSkin. The framework accounts for the phase change of the permeant from dissolved in a solvent (liquid) to precipitated on the skin surface (solid). The evaporation rate for the solid is reduced due to lower vapor pressure for the solid state versus subcooled liquid.

View Article and Find Full Text PDF

Long-term metabolic effects of non-nutritive sweeteners.

Mol Metab

October 2024

The Dalia and David Arabov Endocrinology and Diabetes Research Center, Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Tel-Hashomer, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Objective: Excessive consumption of added sugars has been linked to the rise in obesity and associated metabolic abnormalities. Non-nutritive sweeteners (NNSs) offer a potential solution to reduce sugar intake, yet their metabolic safety remains debated. This study aimed to systematically assess the long-term metabolic effects of commonly used NNSs under both normal and obesogenic conditions.

View Article and Find Full Text PDF
Article Synopsis
  • IL6 signaling is crucial for initiating labor and is a biomarker for infections causing preterm labor, studied using human and non-human primate samples.
  • Pregnant women with chorioamnionitis and Rhesus macaques were subjected to tests involving inflammation induction and signaling blockers to analyze IL6's role in labor.
  • Results showed that IUI led to significant IL6 expression in fetal membranes, and blocking IL1 and TNF signaling reduced IL6 trans-signaling, indicating potential therapeutic options for managing inflammatory responses during pregnancy.
View Article and Find Full Text PDF

Type 2 diabetes (T2D) is caused by both genetic and environmental factors and is associated with an increased risk of cardiorenal complications and mortality. Though disproportionately affected by the condition, African Americans (AA) are largely underrepresented in genetic studies of T2D, and few estimates of heritability have been calculated in this race group. Using genome-wide association study (GWAS) data paired with phenotypic data from ~ 19,300 AA participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, Genetics of Hypertension Associated Treatments (GenHAT) study, and the Electronic Medical Records and Genomics (eMERGE) network, we estimated narrow-sense heritability using two methods: Linkage-Disequilibrium Adjusted Kinships (LDAK) and Genome-Wide Complex Trait Analysis (GCTA).

View Article and Find Full Text PDF

Oral Sebetralstat for On-Demand Treatment of Hereditary Angioedema Attacks.

N Engl J Med

July 2024

From the Division of Allergy and Immunology, University of California, San Diego, La Jolla (M.A.R.); the Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary (H.F.); University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt (E.A.-P.), and the Institute of Allergology, Charité-Universitätsmedizin Berlin, Freie Universitätsmedizin Berlin and Humboldt-Universität zu Berlin, and Immunology and Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology, Berlin (M.M.) - all in Germany; Naval Hospital of Athens, Athens (F.P.); Asthma and Allergy Associates, Colorado Springs (D.F.S.), and IMMUNOe Research Center, Centennial (I.M.) - both in Colorado; Clinical Center of Allergology, Clinic of Allergy and Asthma, University Hospital Alexandrovska, Medical University of Sofia, Sofia, Bulgaria (M.S.); the Department of Systems Medicine, University of Padua, Padua (M.C.), and Operative Unit of Medicine, Angioedema Center, IRCCS Policlinico San Donato, San Donato Milanese, and Dipartimento di Scienze Biomediche per la salute, University of Milan, Milan (A.Z.) - all in Italy; Tel Aviv Sourasky Medical Center (D.H.) and Sheba Medical Center (N.A.-L.), Tel Aviv, and Bnai Zion Medical Center, Haifa (A.K.) - all in Israel; Chiba University Hospital, Chiba, Japan (D.H.); the Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds (S.S.), and KalVista Pharmaceuticals, Salisbury (P.K.A., J.H., M.I., M.D.S., C.M.Y.) - both in the United Kingdom; Jagiellonian University Medical College, Krakow (M.S.), and Medical University of Lodz, Lodz (M.K.) - both in Poland; Icahn School of Medicine at Mount Sinai, New York (P.J.B.); Allergy and Clinical Immunology Department, Centro Hospitalar Universitário de S. João, and Faculty of Medicine, University of Porto, Porto, Portugal (E.D.); Marycliff Clinical Research, Spokane, WA (R.G.); Hospital Universitario Bellvitge de L'Hospitalet de Llobregat, Allergology Department, Barcelona (R.L.); University Clinic of Dermatology, School of Medicine, University Saints Cyril and Methodus, Skopje, North Macedonia (V.G.P.); Washington University School of Medicine, St. Louis (H.J.W.); KalVista Pharmaceuticals, Cambridge, MA (P.K.A., J.H., M.I., M.D.S., C.M.Y.); AARA Research Center, Dallas (W.R.L.); the University of Cincinnati College of Medicine and Bernstein Clinical Research Center, Cincinnati (J.A.B.); and the Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam (D.M.C.).

Article Synopsis
  • * Results showed that both doses of sebetralstat provided significantly quicker relief from symptoms and attack severity compared to the placebo, with median times to relief around 1.6-1.8 hours versus over 6 hours for placebo.
  • * The trial included 136 participants who treated 264 attacks, demonstrating that sebetralstat could potentially offer a more convenient oral alternative to current parenteral treatments for hereditary angioedema.
View Article and Find Full Text PDF

Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more.

PLoS Negl Trop Dis

May 2024

Departments of Ophthalmology and Visual Science, The University of Chicago, Chicago, Illinois, United States of America.

Background: Congenital toxoplasmosis is a treatable, preventable disease, but untreated causes death, prematurity, loss of sight, cognition and motor function, and substantial costs worldwide.

Objectives: We asked whether high performance of an Immunochromatographic-test (ICT) could enable accurate, rapid diagnosis/treatment, establishing new, improved care-paradigms at point-of-care and clinical laboratory.

Methods: Data were obtained in 12 studies/analyses addressing: 1-feasibility/efficacy; 2-false-positives; 3-acceptability; 4-pink/black-line/all studies; 5-time/cost; 6-Quick-Information/Limit-of-detection; 7, 8-acute;-chronic; 9-epidemiology; 10-ADBio; 11,12-Commentary/Cases/Chronology.

View Article and Find Full Text PDF

Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review.

J Am Coll Cardiol

May 2024

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; CIBER en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Cardiology Department, IIS-Fundación Jiménez Díaz University Hospital, Madrid, Spain. Electronic address:

Article Synopsis
  • Cardiovascular disease (CVD) is the top cause of illness and death worldwide, largely due to atherosclerosis, which affects about two-thirds of CVD patients.
  • Atherosclerosis develops over many years, offering a chance for preventive measures to avoid serious events like heart attacks and strokes, especially since early signs are seen in younger people.
  • There's a need for a shift in focus from treating advanced CVD to detecting it early; research should explore using precision medicine and biomarkers to identify atherosclerosis sooner and assess if this could lower healthcare costs globally.
View Article and Find Full Text PDF

Editorial: New Insights Into the Complexities and Neurocognitive Correlates of Sleep in Adolescents with Attention-Deficit/Hyperactivity Disorder.

J Am Acad Child Adolesc Psychiatry

May 2024

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, and the University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Despite decades-long interest in sleep in individuals with attention-deficit/hyperactivity disorder (ADHD)-"restless sleep" was a symptom for diagnosing attention deficit disorder in the Third Edition of the DSM-our understanding of its role in the pathophysiology, trajectories, and functional outcomes of ADHD remains far from complete. This is perhaps no more so the case than in the developmental period of adolescence. The oft-described "perfect storm" of short and ill-timed sleep coinciding with bioregulatory maturation during adolescence may be further intensified for adolescents with ADHD, who often experience wide-ranging and intensifying functional impairments.

View Article and Find Full Text PDF