2 results match your criteria: "the University of California Davis (UC Davis)[Affiliation]"
KSHV vIL-6 enhances inflammatory responses by epigenetic reprogramming.
PLoS Pathog
November 2023
Department of Dermatology, School of Medicine, the University of California Davis (UC Davis), Sacramento, California, United States of America.
Kaposi sarcoma-associated herpesvirus (KSHV) inflammatory cytokine syndrome (KICS) is a newly described chronic inflammatory disease condition caused by KSHV infection and is characterized by high KSHV viral load and sustained elevations of serum KSHV-encoded IL-6 (vIL-6) and human IL-6 (hIL-6). KICS has significant immortality and greater risks of other complications, including malignancies. Although prolonged inflammatory vIL-6 exposure by persistent KSHV infection is expected to have key roles in subsequent disease development, the biological effects of prolonged vIL-6 exposure remain elusive.
View Article and Find Full Text PDFKSHV vIL-6 Enhances Inflammatory Responses by Epigenetic Reprogramming.
bioRxiv
July 2023
Department of Dermatology, School of Medicine, the University of California Davis (UC Davis), Sacramento, California USA.
Article Synopsis
- KSHV inflammatory cytokine syndrome (KICS) is a chronic inflammatory disease triggered by KSHV infection, marked by high viral loads and elevated levels of both KSHV-encoded IL-6 and human IL-6.
- Prolonged exposure to vIL-6 impacts chromatin changes and promotes increased recruitment of proteins like BRD4, leading to sustained production of inflammatory cytokines such as hIL-6 and IL-10.
- Using a BRD4 inhibitor, research showed that blocking this pathway could reduce excessive inflammatory responses, highlighting a potential link between persistent vIL-6 exposure and chronic inflammatory diseases in KSHV-infected patients.