Images: Combined positive air way pressure and atomoxetine-oxybutynin for the treatment of severe obstructive sleep apnea.

Obstructive sleep apnea (OSA) is one of the most common sleep disorders. Positive airway pressure therapy (PAP) is considered the gold standard for treating OSA. Yet, optimal therapy might not be achieved in some cases of severe OSA, despite using maximum settings.

Guidance on Preoperative Management of Hand Surgery Patients Taking GLP-1 Receptor Agonists.

Glucagon-like peptide-1 (GLP-1) receptor agonists are medications used to treat type 2 diabetes and may aid in weight loss efforts. The surgical management of patients taking GLP-1 agonists differs from others due to the slowed gastric emptying effects of GLP-1 medications. Patients taking these medications may have a higher risk of pulmonary aspiration during hand surgery than other patients, which affects their presurgical management.

Factors Associated With Increased Sex Diversity in Orthopaedic Trauma Association-Accredited Fellowship Training.

Introduction: This study quantifies the state of sex diversity in orthopaedic trauma training and analyzes fellowship program characteristics associated with greater sex diversity among trainees. We hypothesized that greater sex diversity among orthopaedic trauma fellows would be associated with the presence of female faculty.

Methods: This was a retrospective, cross-sectional study of orthopaedic trauma faculty (2023 to 2024) and fellows (2009 to 2024).

Breaking the Cycle of Nurse Manager Presenteeism: A Convergent Mixed-Methods Study.

Objective: The aim was to describe the factors leading to, and explore the coping strategies and the consequences of, nurse manager presenteeism.

Background: Presenteeism, or presence at work while not fully performing, is prevalent among direct-care nurses, yet no studies have explored nurse manager presenteeism.

Methods: This study used a convergent mixed-methods design with 1:1 interviews, a demographic questionnaire, mental/physical health and work situation questions, and the Job Stress-Related Presenteeism Scale (JSPS).

Solvent-Free Silsesquioxane Self-Welding for 3D Printing Multi-Refractive Index Glass Objects.

The growing interest in 3D printing of silica glass has spurred substantial research efforts. Our prior work utilizing a liquid silica resin (LSR) demonstrated high printing accuracy and resolution. However, the resin's sensitivity to moisture posed limitations, restricting the printing environment.

No One Dies Alone: Developing A Comfort Care Home for Unhoused, Isolated, and Vulnerable Individuals.

This report highlights the development of Grace House Akron, Inc. (GHA) a comfort care home focused on caring for terminally ill individuals who are unhoused, isolated, without caregivers, economically disadvantaged and face end of life alone. GHA is a free-standing home that provides safe housing, a nurturing environment, and round-the-clock personal care while local hospice agencies provide medical management.

Revisiting ICD Therapy for Primary Prevention in Patients With Heart Failure and Reduced Ejection Fraction.

Implantable cardioverter-defibrillators (ICDs) are recommended to reduce the risk of sudden cardiac death (SCD) in patients with heart failure with reduced ejection fraction (HFrEF). The landmark studies leading to the current guideline recommendations preceded the 4 pillars of guideline-directed medical therapies (GDMTs). Therefore, some have questioned the role of ICDs for primary prevention in current clinical practice.

Assessing strategies to measure hidden per- and polyfluoroalkyl substances (PFAS) in groundwater and to evaluate adsorption remediation efficiencies.

The widespread presence of per- and polyfluoroalkyl substances (PFAS) in the environment, driven by extensive industrial use, has raised global concerns due to their persistence and adverse health effects. Despite the increased regulatory focus on a sub-set of well-known PFAS, over 12,000 compounds exist, many poorly characterized. Our study assessed hidden PFAS concentrations, undetectable by standard LC-MS/MS analysis, in contaminated groundwater.

Approach to the patient with hidradenitis suppurativa: Evaluating severity to guide therapy.

Hidradenitis suppurativa (HS) is a chronic condition with a multifaceted pathoetiology requiring a multimodal management approach. The HS evaluation process involves the use of multiple tools to determine the extent and activity of disease, patient-reported outcomes, and the effectiveness of therapy. The multimodal approach to treatment based on severity includes lifestyle modifications, topical medications, systemic antibiotics, immunomodulators, and surgical interventions.

Whispering gallery mode optical resonators for biological and chemical detection: current practices, future perspectives, and challenges.

Sensors are important for a wide variety of applications include medical diagnostics and environmental monitoring. Due to their long photon confinement times, whispering gallery mode (WGM) sensors are among the most sensitive sensors currently in existence. We briefly discuss what are WGM sensors, the principles of WGM sensing, and the history of the field, beginning with Mie theory.

Interplay of elasticity and flow velocity on gorgonian feeding and implications for bioinspired design.

Evidence shows that gorgonians are more resistant to ocean acidification and rising temperatures than hard corals and are vital to reef health and the reestablishment of disrupted coral reef communities. Gorgonian coral's resilience and its diversity of morphology and environment make it well-suited as a model organism for bioinspired design applied to particle capture. We focus on flow near the polyps, using an updated form of the immersed boundary method to model the fluid-structure interaction of the flexible polyps and the surrounding ocean water.

European Respiratory Society Research Seminar on Preventing Pediatric Asthma.

This report is a summary of the presentations given at the European Respiratory Society's Research Seminar on Asthma Prevention. The seminar reviewed both epidemiological and mechanistic studies and concluded that; (i) reducing exposure of pregnant women and children to air pollution will reduce incident asthma, (ii) there are promising data that both fish oil and a component of raw cow's milk prevent asthma, and (iii) modulating trained immunity by either mimicking helminth infection or oral and sublingual bacterial products is a promising area of research.

Integrating artificial intelligence with smartphone-based imaging for cancer detection in vivo.

Cancer is a major global health challenge, accounting for nearly one in six deaths worldwide. Early diagnosis significantly improves survival rates and patient outcomes, yet in resource-limited settings, the scarcity of medical resources often leads to late-stage diagnosis. Integrating artificial intelligence (AI) with smartphone-based imaging systems offers a promising solution by providing portable, cost-effective, and widely accessible tools for early cancer detection.

The impact of insurance status on psoriasis patients' healthcare-seeking behavior: a population-based study in the United States.

Background: Psoriasis is a chronic, inflammatory skin condition requiring long-term care. However, many psoriasis patients may not regularly receive care. Several factors affect access to care in the United States, including health insurance status.

Individual- and community-level risk factors for maternal morbidity and mortality among Native American women in the USA: a systematic review.

Introduction And Objective: Maternal morbidity and mortality (MMM) is a public health concern in the USA, with Native American women experiencing higher rates than non-Hispanic White women. Research on risk factors for MMM among Native American women is limited. This systematic review comprehensively synthesizes and critically appraises the literature on risk factors for MMM experienced by Native American women.

Patient perceptions of their experience with comprehensive medication reviews: A framework for continued quality improvement.

Background: A comprehensive medication review (CMR) is an annual service offered to eligible Medicare Part D beneficiaries as a component of the Medication Therapy Management program. However, little is known about the most meaningful aspect of CMRs from the patient's perspective. This information is necessary to help improve the service.

Randomized in error in pragmatic clinical trials.

Background: Pragmatic trials that combine electronic health record data and patient-reported data may be subject to selection bias due to the differential post-randomization exclusion of participants who are randomized in error. Such situations are often caused by inevitable reasons, such as incomplete patient medical records at the pre-randomization stage. This can lead to participants in the intervention arm being identified as ineligible after randomization, while randomized-in-error participants in the usual care are often not discernable.

Assessment of the link between life purpose and health.

Background: This study examined the temporal relations between a decline in health and changes in life purpose to better understand the causal direction between life purpose and morbidity.

Methods: Over a 16-year period, 7598 individuals completed up to four quadrennial surveys, which included information on 14 health metrics (lung function, grip strength, walking speed, balance and diagnoses of hypertension, diabetes, cancer, lung disease, heart condition, stroke, psychiatric problem, arthritis, dementia and Alzheimer's) and life purpose. Ordinary and logistic regressions were used to examine the temporal relations between changes in purpose and changes in health over both the same 4-year period and over the subsequent 8 years.

Examining Indigenous Identity as a Protective Factor in Mental Well-Being Research in the United States: A Scoping Review.

Due to historical and ongoing structural racism and settler colonialism, Indigenous Peoples and communities in the United States are at a higher risk for a variety of diseases, elevated stress, and negative mental health outcomes. In addition, the United States federal government and the public encourage a view that Indigenous Peoples are primarily a racial group. Federally-, state-, and un-recognized Indigenous Peoples have a collective right to self-determination and sovereignty, and individuals of these Peoples understand this.

Ultra-wideband microstrip folded antenna for wireless LAN, 5G and Internet of Things applications.

This paper presents an ultra-wideband (UWB) microstrip antenna with a simple structure operating at 2.2-6 GHz bandwidth. The proposed antenna has been demonstrated for its suitability in UWB and multi-band applications, such as wireless local area network (WLAN), Wi-Fi, 5G, Internet of Things (IoT), etc.