2,011 results match your criteria: "the Third XiangYa Hospital of Central South University[Affiliation]"
ACS Nano
November 2024
Center for Surgical Bioengineering, Department of Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, United States.
In utero gene editing with mRNA-based therapeutics has the potential to revolutionize the treatment of neurodevelopmental disorders. However, a critical bottleneck in clinical application has been the lack of mRNA delivery vehicles that can efficiently transfect cells in the brain. In this report, we demonstrate that in utero intracerebroventricular (ICV) injection of densely PEGylated lipid nanoparticles (ADP-LNPs) containing an acid-degradable PEG-lipid can safely and effectively deliver mRNA for gene editing enzymes to the fetal mouse brain, resulting in successful transfection and editing of brain cells.
View Article and Find Full Text PDFCardiol Young
October 2024
Department of Pediatrics, the Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China.
Curr Treat Options Oncol
November 2024
Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Multiple myeloma (MM) is a heterogeneous plasma cell tumor with a survival period of several months to over ten years. Despite the development of various new drugs, MM is still incurable and recurs repeatedly. Bortezomib, a landmark event in the history of MM treatment, has dramatically improved the prognosis of patients with MM.
View Article and Find Full Text PDFGene
January 2025
Department of Hepatobiliary Surgery, Haikou People's Hospital, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou 570208, PR China. Electronic address:
Introduction: Hepatocellular Carcinoma (HCC) is a common malignant tumor worldwide. Long Non-Coding RNA (lncRNA) has gained attention in tumor biology, and this study aims to investigate the role of lncRNA SNHG3 in HCC, specifically in the self-renewal and maintenance of liver cancer stem cells.
Methods: The expression of lncRNA SNHG3 was analyzed in HCC and adjacent normal tissue using the TCGA database.
Inflamm Bowel Dis
October 2024
Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, P.R. China.
Immun Inflamm Dis
October 2024
Department of Respiratory and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha City, Hunan Province, China.
BMC Public Health
October 2024
School of Medicine, Hunan Normal University, 371 Tongzipo Road, Changsha, Hunan, 410013, China.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
School of Life Sciences, Central South University, Changsha, China. Electronic address:
J Orthop Surg Res
October 2024
Department of Orthopaedics, The Third Xiangya Hospital of Central South University, 410013, Changsha, Hunan, China.
Phenomics
June 2024
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410083 China.
Inflammopharmacology
December 2024
Department of Anesthesiology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, China.
Br J Radiol
January 2025
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Virulence
December 2024
Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, China.
With the growing antibiotic resistance in , it is imperative to develop innovative therapeutic strategies against new targets to reduce selective survival pressures and incidence of resistance. In , interbacterial communication relies on a quorum sensing system that regulates gene expression and physiological activities. Here, we identified that Visomitin, an antioxidant small molecule, exhibited bactericidal efficacy against methicillin-resistant and its high tolerance phenotypes like intracellular bacteria and persister cells without inducing resistance.
View Article and Find Full Text PDFNPJ Precis Oncol
October 2024
MD, Department of otolaryngology head and neck surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Sci Rep
October 2024
Department of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Hexi Yuelu District, Changsha City, Hunan Province, China.
Clin Ther
December 2024
Department of Transplant Surgery, the Third Xiangya Hospital of Central South University, Changsha, China; Engineering and Technology Research Center for Transplantation Medicine of National Health Commission, the Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:
Purpose: This study aimed to investigate the incidence, timing, risk factors, and impacts of invasive Candida infections (ICIs) within 3 months after liver transplantation (LT) on LT recipients' prognosis.
Methods: Patients undergoing LT from January 2015 to December 2022 in a tertiary university hospital were investigated the incidence, onset, and risk factors of ICIs and the effects of ICIs on the outcome of LT recipients using statistical methods.
Findings: The mean age of involved 389 LT recipients was 47.
Autoimmun Rev
November 2024
Department of Pediatrics, The Second Xiangya Hospital of Central South University, 410011 Changsha, China. Electronic address:
BMC Cardiovasc Disord
October 2024
Department of Nephrology, Xiangya Hospital of Central South University, Changsha, China.
Background: Primary electrical disorders (PEDs) are a group of cardiac rhythm abnormalities that occur in the absence of detectable structural heart disease and are a significant cause of sudden cardiac death (SCD). The initiation of cardiac muscle contraction and relaxation is orchestrated by the action potential (AP), generated through ionic changes across the membrane. Mutations in the AP-related gene CACNA2D1 have been identified as a causative factor for PED.
View Article and Find Full Text PDFCurr Cancer Drug Targets
September 2024
Department of Oncology, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, P.R. China.
Background: Ferroptosis is closely related to radiotherapy resistance in multiple can-cers. Herein, the role of microsomal glutathione S-transferase 1 (MGST1) in regulating ferropto-sis and radiotherapy resistance in non-small cell lung cancer (NSCLC) was investigated.
Methods: Radiation-resistant NSCLC cells (NCI-1299-IR and HCC827-IR cells) were estab-lished.
Eur J Pharmacol
December 2024
Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China. Electronic address:
BMC Cancer
September 2024
Department of Oncology, The Third Xiangya Hospital of Central South University, Central South University, Changsha, China.
JAMA Dermatol
November 2024
Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.
Burns
December 2024
The Third Xiangya Hospital of Central South University, No.138, Tongzipo Road, YueLu District, Changsha 410013, Hunan Province, China. Electronic address:
J Inflamm Res
September 2024
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Objective: Inflammation plays a crucial role in the development of metabolic syndrome (MetS). However, the roles of pepsinogens (PGs) and gastrin, known biomarkers linked to gastric inflammation, in MetS and the transition of MetS status are unclear. This research aimed to explore the relationship between MetS, the transition of MetS status, and levels of gastric biomarkers.
View Article and Find Full Text PDFZhonghua Yu Fang Yi Xue Za Zhi
September 2024
Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
This study investigated the association between serum 25(OH)D levels and cardiovascular risk-related indicators. 4 727 participants aged 20 and above from the National Health and Nutrition Examination Survey 2015-2018 database were enrolled. Body mass index, hypersensitive C-reactive protein, high density lipoprotein cholesterol, systolic blood pressure, waist-height ratio, and total cholesterol were selected as the research indicators.
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