2,011 results match your criteria: "the Third XiangYa Hospital of Central South University[Affiliation]"

Widespread Gene Editing in the Brain via In Utero Delivery of mRNA Using Acid-Degradable Lipid Nanoparticles.

ACS Nano

November 2024

Center for Surgical Bioengineering, Department of Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, United States.

In utero gene editing with mRNA-based therapeutics has the potential to revolutionize the treatment of neurodevelopmental disorders. However, a critical bottleneck in clinical application has been the lack of mRNA delivery vehicles that can efficiently transfect cells in the brain. In this report, we demonstrate that in utero intracerebroventricular (ICV) injection of densely PEGylated lipid nanoparticles (ADP-LNPs) containing an acid-degradable PEG-lipid can safely and effectively deliver mRNA for gene editing enzymes to the fetal mouse brain, resulting in successful transfection and editing of brain cells.

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  • Kawasaki disease is a systemic vasculitis primarily affecting infants and young children, and this study focused on the genetic factors, specifically the rs1412125 and rs2249825 single nucleotide polymorphisms (SNPs) in the HMGB1 gene, that may influence the disease and its complications like coronary artery injury.
  • Researchers analyzed 200 children with Kawasaki disease (49 with coronary artery injury) alongside 200 healthy controls using genetic sequencing techniques to compare SNP distributions and assess statistical associations.
  • The study found that specific genotype and allele variations at the rs1412125 locus were significantly associated with increased risk for Kawasaki disease and its coronary artery complications, indicating a potential genetic vulnerability in affected individuals.
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Multiple myeloma (MM) is a heterogeneous plasma cell tumor with a survival period of several months to over ten years. Despite the development of various new drugs, MM is still incurable and recurs repeatedly. Bortezomib, a landmark event in the history of MM treatment, has dramatically improved the prognosis of patients with MM.

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Investigating SNHG3 as a potential therapeutic approach for HCC stem cells.

Gene

January 2025

Department of Hepatobiliary Surgery, Haikou People's Hospital, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou 570208, PR China. Electronic address:

Introduction: Hepatocellular Carcinoma (HCC) is a common malignant tumor worldwide. Long Non-Coding RNA (lncRNA) has gained attention in tumor biology, and this study aims to investigate the role of lncRNA SNHG3 in HCC, specifically in the self-renewal and maintenance of liver cancer stem cells.

Methods: The expression of lncRNA SNHG3 was analyzed in HCC and adjacent normal tissue using the TCGA database.

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  • IBD is linked to colorectal cancer (CRC) due to chronic inflammation, with macrophages playing a crucial role in tumor progression through their exosomes.
  • The study examined the impact of macrophage-derived exosomes containing NEAT1 on CRC growth and stemness, utilizing various molecular and cellular assays.
  • Results revealed that NEAT1 promotes CRC progression by sponging miR-34a-5p, while inhibiting NEAT1 can effectively reduce tumor growth, suggesting it as a potential therapeutic target for CRC.
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  • Asthma has two main types, T2 high and low, influenced by dendritic cells (DCs) and their autophagy levels, with enhanced autophagy promoting Th2 and reduced autophagy leading to Th17 differentiation.
  • Researchers analyzed gene expression data to identify differentially expressed genes (DEGs) in two types of DCs after exposure to allergens, employing various bioinformatics tools to understand the genes involved in asthma regulation.
  • The study found significant gene expression changes, identifying 35 hub genes, particularly noting the gene Gngt2, which was elevated in a low asthma model but did not differ significantly in high asthma conditions compared to controls.
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  • Hypertension is a growing global health issue linked to increased mortality, and physical activity (PA) is a key treatment for managing blood pressure, yet adherence rates to PA remain low.
  • A comprehensive qualitative study analyzed 17 research articles to identify factors influencing PA among hypertensive patients, focusing on capabilities, opportunities, and motivators related to physical activity.
  • Key findings suggest that for effective PA programs, a personalized approach should be taken, addressing individual capacities, providing resources and social support, and enhancing motivation through positive PA experiences.
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Fluorescence detection of adenosine triphosphate based on dimeric G-quadruplex.

Spectrochim Acta A Mol Biomol Spectrosc

February 2025

School of Life Sciences, Central South University, Changsha, China. Electronic address:

Article Synopsis
  • ATP is a crucial energy carrier in living organisms, linked to various biological processes and diseases, making it an important biomarker for cell viability and food freshness.
  • * The study presents a new ATP detection sensor that utilizes the fluorescence change of dimeric G-quadruplex (Di-G4) in the presence of ATP, showing a linear relationship between fluorescence and ATP concentrations.
  • * When tested on apples, this novel method demonstrated reliable results when compared to traditional ATP assay kits, indicating its potential for practical applications.
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  • The study investigates the effectiveness of various arthroscopic procedures for treating rotator cuff diseases, focusing on the outcomes of arthroscopic rotator cuff repair compared to other interventions.
  • A total of 1,232 patients from 16 studies were analyzed, revealing that arthroscopic repair significantly improved shoulder function and outperformed other methods, while physiotherapy was more effective for pain relief.
  • The research highlights the need for caution due to moderate bias risks in the included studies and suggests that further evidence is necessary to solidify these conclusions.
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  • * A standardized system for collecting and categorizing this data has been developed, including specific recommendations for measurement techniques and equipment based on usage contexts.
  • * A multi-center collaboration in China seeks to gather data on various skin conditions, linking it to disease information to better understand skin phenotype influences and improve treatment methods, while also working on non-invasive measurement technologies.
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  • This study investigated the effectiveness and safety of a new pain medication, QP001, for managing postoperative pain in patients after orthopaedic surgery in China.
  • In a clinical trial with 198 participants, those taking QP001 consumed significantly less morphine for pain relief compared to those receiving a placebo, both at 24 hours and 48 hours post-surgery.
  • QP001 not only reduced the need for opioids but also had fewer adverse drug reactions, indicating it could be a promising alternative for pain management after surgery.
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  • The study aimed to evaluate the effectiveness of strain elastography (SE) in improving the categorization of ultrasound Breast Imaging Reporting and Data System (BI-RADS) 3 and 4a lesions, potentially reducing unnecessary biopsies.
  • A total of 4,371 patients were analyzed, using various methods to combine BI-RADS with elasticity scores and strain ratios, which showed improved diagnostic performance compared to BI-RADS alone.
  • The findings suggested that downgrading only BI-RADS 4a lesions might be sufficient for maintaining a high diagnostic accuracy, thereby decreasing false-positive rates in breast biopsies.
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With the growing antibiotic resistance in , it is imperative to develop innovative therapeutic strategies against new targets to reduce selective survival pressures and incidence of resistance. In , interbacterial communication relies on a quorum sensing system that regulates gene expression and physiological activities. Here, we identified that Visomitin, an antioxidant small molecule, exhibited bactericidal efficacy against methicillin-resistant and its high tolerance phenotypes like intracellular bacteria and persister cells without inducing resistance.

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  • The study focuses on head and neck squamous cell carcinoma (HNSCC) and its metastasis, analyzing data from 702,446 cells to find a new subtype of cancer-associated fibroblasts (CAFs) called SFRP2_CAFs.
  • SFRP2_CAFs, derived from smooth muscle cells, show distinct traits that relate to worse survival in HNSCC patients and exhibit interactions with tumor-associated macrophages that promote tumor spread.
  • The research highlights NFIX as a crucial transcription factor that influences the behavior of SFRP2_CAFs, using advanced gene regulatory network analysis for validation.
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Physical activity combined with tea consumption could further reduce all-cause and cancer-specific mortality.

Sci Rep

October 2024

Department of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Hexi Yuelu District, Changsha City, Hunan Province, China.

Article Synopsis
  • * Results showed that both PA and tea consumption independently lower the risk of all-cause mortality, with even greater benefits observed when both are combined, particularly for those who are physically active.
  • * However, tea consumption alone did not significantly affect cancer-specific mortality; it was only beneficial for individuals who were also physically active.
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The Influence of Invasive Candida Infections on Prognosis and Analysis of Their Risk Factors After Liver Transplantation.

Clin Ther

December 2024

Department of Transplant Surgery, the Third Xiangya Hospital of Central South University, Changsha, China; Engineering and Technology Research Center for Transplantation Medicine of National Health Commission, the Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:

Purpose: This study aimed to investigate the incidence, timing, risk factors, and impacts of invasive Candida infections (ICIs) within 3 months after liver transplantation (LT) on LT recipients' prognosis.

Methods: Patients undergoing LT from January 2015 to December 2022 in a tertiary university hospital were investigated the incidence, onset, and risk factors of ICIs and the effects of ICIs on the outcome of LT recipients using statistical methods.

Findings: The mean age of involved 389 LT recipients was 47.

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  • Autoimmune diseases happen when the body's immune system mistakenly attacks its own healthy cells, causing damage and inflammation.
  • Omega-3 fatty acids, found in foods like fish, might help reduce this inflammation, but scientists aren't sure how effective they are for different autoimmune diseases.
  • A study analyzed 21 previous studies and found that omega-3s seem to help with some autoimmune diseases like rheumatoid arthritis and lupus but didn’t provide clear evidence for their effects on others like psoriasis and type 1 diabetes.
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Background: Primary electrical disorders (PEDs) are a group of cardiac rhythm abnormalities that occur in the absence of detectable structural heart disease and are a significant cause of sudden cardiac death (SCD). The initiation of cardiac muscle contraction and relaxation is orchestrated by the action potential (AP), generated through ionic changes across the membrane. Mutations in the AP-related gene CACNA2D1 have been identified as a causative factor for PED.

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Background: Ferroptosis is closely related to radiotherapy resistance in multiple can-cers. Herein, the role of microsomal glutathione S-transferase 1 (MGST1) in regulating ferropto-sis and radiotherapy resistance in non-small cell lung cancer (NSCLC) was investigated.

Methods: Radiation-resistant NSCLC cells (NCI-1299-IR and HCC827-IR cells) were estab-lished.

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Sonic hedgehog signaling facilitates pyroptosis in mouse heart following ischemia/reperfusion via enhancing the formation of CARD10-BCL10-MALT1 complex.

Eur J Pharmacol

December 2024

Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China. Electronic address:

Article Synopsis
  • Pyroptosis is a form of cell death contributing to heart damage during ischemia/reperfusion (I/R) injury, but the mechanisms behind it are still not fully understood.
  • The study investigates how Sonic hedgehog (SHH) signaling, which is activated during I/R events, protects the heart by reducing pyroptosis through the caspase recruitment domain-containing protein 10 (CARD10)-B-cell lymphoma 10 (BCL10)-mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) complex.
  • Findings suggest that inhibiting SHH signaling lessens heart damage by decreasing caspase-11-dependent pyroptosis and reducing formation of the CBM complex,
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  • A dosimetric evaluation was conducted on 49 stage III NSCLC patients treated with 4D-CT IMRT, focusing on the impact of omitting the clinical target volume (CTV).
  • Results showed that omitting the CTV at a lower dose of 60 Gy provided inadequate coverage for the target area, while increasing the dose to 74 Gy significantly improved coverage for more patients.
  • The simultaneous integrated boost (SIB-IMRT) plan offered the best protection for surrounding normal tissues and organs, suggesting it could be the optimal radiation therapy approach for these patients.
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  • China faces a significant challenge with postherpetic neuralgia, necessitating effective new treatment options that minimize neurotoxic effects compared to current calcium channel ligands.
  • The study aimed to evaluate the efficacy and safety of crisugabalin, a new oral medication, involving a randomized clinical trial across 48 care centers in China, which included a 12-week treatment phase and a subsequent 14-week extension phase.
  • Results showed improvement in pain relief for patients taking crisugabalin, particularly at the 40 mg and 80 mg doses, highlighting its potential as a more effective treatment for managing postherpetic neuralgia compared to a placebo.
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  • This study investigates the genetic differences between postburn keloids and hypertrophic scars using single-cell sequencing to identify molecular biomarkers for accurate diagnosis.
  • Researchers conducted analyses on clinical samples to find genes that could distinguish between the two types of scars, focusing on fibroblast cells.
  • They identified two key genes, insulin-like growth factor binding protein 6 and tumor necrosis factor alpha-induced protein 6, which showed high diagnostic accuracy for differentiating keloids from hypertrophic scars.
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The Gastric Connection: Serum Gastric Biomarkers, Metabolic Syndrome and Transition in Metabolic Status.

J Inflamm Res

September 2024

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Objective: Inflammation plays a crucial role in the development of metabolic syndrome (MetS). However, the roles of pepsinogens (PGs) and gastrin, known biomarkers linked to gastric inflammation, in MetS and the transition of MetS status are unclear. This research aimed to explore the relationship between MetS, the transition of MetS status, and levels of gastric biomarkers.

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This study investigated the association between serum 25(OH)D levels and cardiovascular risk-related indicators. 4 727 participants aged 20 and above from the National Health and Nutrition Examination Survey 2015-2018 database were enrolled. Body mass index, hypersensitive C-reactive protein, high density lipoprotein cholesterol, systolic blood pressure, waist-height ratio, and total cholesterol were selected as the research indicators.

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