Hsa_circ_0084927 Regulates Cervical Cancer Advancement via Regulation of the miR-634/TPD52 Axis.

Background: Cervical cancer (CC) is a common gynecological tumor that affects women's health. Circular RNA hsa_circ_0084927 (hsa_circ_0084927) has been reported to be upregulated in CC. However, the role and regulatory mechanism of hsa_circ_0084927 in CC are unclear.

Long noncoding RNA HCP5 suppresses skin cutaneous melanoma development by regulating gene expression via sponging miR-12.

Objective: This research aimed to investigate the role and mechanism of long noncoding RNA (lncRNA) HCP5 in skin cutaneous melanoma (SKCM).

Materials And Methods: Survival analysis was performed using The Cancer Genome Atlas (TCGA)-SKCM data and SKCM patients' clinical data. Primary SKCM cells were derived from patients' pathologic tissue specimens.

miR-497 promotes the progression of cutaneous squamous cell carcinoma through FAM114A2.

Objective: To explore the possible role and mechanism of miR-497 in cutaneous squamous cell carcinoma.

Patients And Methods: Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to detect miR-497 and FAM114A2 expression level in 38 cases of cutaneous squamous cell carcinoma (CSCC) and 22 normal skin tissues as well as in CSCC cell lines (A431, HSC-5) and normal cells (HaCaT). MiR-497 effects on cell proliferation and cell cycle were examined by CCK8 assays and flow cytometry.

Low expression of microRNA-21 inhibits trophoblast cell infiltration through targeting PTEN.

Objective: We investigate whether microRNA-21 could increase the infiltration ability of trophoblast cells via regulating PTEN expression, thus participating in the occurrence and development of preeclampsia.

Patients And Methods: MicroRNA-21 expression in the placenta tissues of preeclampsia women and normal pregnant women was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The effects of microRNA-21 on cell proliferation and infiltration were examined by cell counting kit-8 (CCK-8) and transwell assay, respectively.

[The clinical value of vestibular autorotation test in the diagnosis of otogenic vertigo].

To explore the clinical value of vestibular autorotation test (VAT) in the treatment for otogenic vertigo patients. One hundred and twenty-nine definite otogenic vertigo patients were included. All patients underwent the VAT and caloric test (CT).

[Identification of the Disease-Associated Genes in Periodontitis Using the Co-expression Network].

The aim of this study was to investigate the disease-associated genes in periodontitis. In the present experiments, the topological analysis of the differential co-expression network was proposed. Using the GSE16134 dataset downloaded from the European Molecular Biology Laboratory-European Bioinformatics Institute, a co-expression network was constructed after the differentially expressed genes (DEGs) were identified between the diseased (242 samples) and healthy (69 samples) gingival tissues from periodontitis patients.

Analysis on correlation of white matter lesion and lacunar infarction with vascular cognitive impairment.

Objective: To investigate the correlation of white matter lesion (WML) and lacunar infarction (LI) with vascular cognitive impairment. To investigate the correlation of cognitive changes of vascular dementia (VD) patients with lacunar infarction (LI) and white matter lesion (WML).

Methods: The clinical data of 60 cases of VD patients were evaluated and analyzed by combining with imageological findings and cognitive function assessment.