2,322 results match your criteria: "the Second Hospital of Shandong University.[Affiliation]"
Origin of Regioselectivity Inversion Tuned by Substrate Electronic Properties in Co(III)-Catalyzed Annulation of N-Chlorobenzamide with Alkenes.
Chempluschem
November 2024
Department of Interventional Medicine and Minimally Invasive Oncology, The Second Hospital of Shandong University, The Institute of Interventional Oncology Shandong University, Jinan, Shandong, 250033, P. R. China.
Article Synopsis
- - The study focuses on how Co(III) acts as a catalyst in reactions between N-chlorobenzamide and various olefins, analyzing how different electron properties of these olefins affect the reaction outcomes.
- - A key finding is that the step where the alkene inserts into the reaction dictates the overall regioselectivity, meaning it influences which products are formed.
- - The energy decomposition analysis (EDA) reveals that when using styrene, a specific insertion is favored due to less repulsion between the particles involved, while a different insertion pathway is preferred with vinyltrimethylsilane because of its higher electron density enhancing stabilizing interactions.
Hypertension Risk and Kidney Function Following Kidney Donation.
JAMA
December 2024
Department of Urology, China Rehabilitation Research Center, Beijing, China.
DTASUnet: a local and global dual transformer with the attention supervision U-network for brain tumor segmentation.
Sci Rep
November 2024
Shandong Key Laboratory of Medical Physics and Image Processing, Shandong Institute of Industrial Technology for Health Sciences and Precision Medicine, School of Physics and Electronics, Shandong Normal University, Jinan, China.
Glioma refers to a highly prevalent type of brain tumor that is strongly associated with a high mortality rate. During the treatment process of the disease, it is particularly important to accurately perform segmentation of the glioma from Magnetic Resonance Imaging (MRI). However, existing methods used for glioma segmentation usually rely solely on either local or global features and perform poorly in terms of capturing and exploiting critical information from tumor volume features.
View Article and Find Full Text PDFMulti-branch fusion graph neural network based on multi-head attention for childhood seizure detection.
Front Physiol
October 2024
Center for Optics Research and Engineering, Shandong University, Qingdao, China.
Article Synopsis
- The study focuses on using a multi-branch graph convolutional network (MGCNA) framework combined with a multi-head attention mechanism to detect epileptic seizures in children.
- MGCNA effectively extracts important features from complex EEG data by analyzing the relationships between different electrodes and considering both spatial and temporal dependencies in the brain.
- Experimental results show that this method outperforms existing techniques for both patient-specific and patient-independent seizure detection, potentially aiding clinical decision-making in epilepsy management.
Case report: Double mutations in a patient with early-onset Alzheimer's disease in China, PSEN2 and IDE variants.
Front Neurosci
October 2024
Department of Neurology, the Second Hospital of Shandong University, Jinan, China.
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by gradual cognitive decline. Early-onset Alzheimer's disease (EOAD) is defined as AD occurring before age 65. The main pathogenic gene variants associated with EOAD include , , and gene has been identified as a risk factor in the pathogenesis of AD.
View Article and Find Full Text PDFInvestigating the causal association between heme oxygenase-1 and asthma: A bidirectional two-sample Mendelian randomization analysis in a European population.
World Allergy Organ J
November 2024
Department of Cardiac Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, China.
Article Synopsis
- A study explored the causal relationship between heme oxygenase-1 (HO-1) and asthma using a two-sample Mendelian randomization approach, analyzing data from genome-wide association studies.
- The findings suggested that higher levels of genetically predicted HO-1 are associated with a lower risk of developing asthma, confirming its protective role.
- In contrast, asthma did not appear to influence HO-1 levels, and these results were consistent across additional datasets and in childhood asthma cases.
Background: Couples undergoing artificial insemination by donor semen(AID) represent a unique group of infertility patients, the relationship between fertility pressure and attachment styles remains unclear. To investigate the fertility pressure and attachment dimensions in artificial insemination by donor semen(AID) couples, and develop an Actor-Partner Interdependence Model (APIM) for patient care.
Methods: This study is a cross-sectional study.
Transcriptome sequencing and Mendelian randomization analysis identified biomarkers related to neutrophil extracellular traps in diabetic retinopathy.
Front Immunol
November 2024
Department of Ophthalmology, the Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Summary: In the development of diabetic retinopathy (DR), neutrophil infiltration hastens the adhesion between neutrophils and endothelial cells, leading to inflammation. Meanwhile, neutrophil extracellular traps (NETs) produced by neutrophils could clear aging blood vessels, setting the stage for retinal vascular regeneration. To explore the mechanism of NETs-related genes in DR, the transcriptome of NETs from normal and DR individuals were analyzed with gene sequencing and mendelian randomization (MR) analysis.
View Article and Find Full Text PDFReply: Baveno VII for HCC-Are we there yet?
Hepatol Commun
November 2024
Department of Infectious Diseases and Hepatology, The Second Hospital of Shandong University, Jinan, China.
Arthroscopic Fixation With Absorbable Suture Anchors for Pipkin Type I Femoral Head Fractures-Letter V Technique.
Arthrosc Tech
October 2024
Department of Sports Medicine, the Second Hospital of Shandong University, Jinan, China.
Article Synopsis
- - Femoral head fractures, often occurring from high-energy impacts, can lead to traumatic hip dislocations and are classified into 4 types by Pipkin based on their location and associated damage.
- - Traditional treatment methods involve open reduction and internal fixation, which can be effective but also carry significant risks and complications.
- - The proposed arthroscopic technique for treating Pipkin type I fractures utilizes absorbable suture anchors for improved stability and involves a double-pulley and triangular suture bridge for secure fixation, representing a less invasive alternative.
Angiotensin-(1-7) improves intestinal microbiota disturbances and modulates fecal metabolic aberrations in acute pancreatitis.
FASEB J
October 2024
Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- Acute pancreatitis (AP) can disrupt intestinal microbiota, and angiotensin (Ang)-(1-7) may help protect the intestinal barrier and modify the microbiota.
- In a study with 31 AP patients and a mouse model, researchers found that Ang-(1-7) administration improved the balance of gut bacteria and reduced pancreatic and intestinal damage.
- The results suggest that Ang-(1-7) can enhance the abundance of beneficial gut bacteria and restore metabolic functions affected by AP, highlighting its potential as a therapeutic approach.
Nomograms for predicting short-term mortality in acute-on-chronic liver disease caused by the combination of hepatitis B virus and alcohol.
Sci Rep
October 2024
Department of Hepatology, The First Hospital of Jilin University, Jilin University, No.71, Xinmin Street, Changchun, 130021, China.
Article Synopsis
- The study focused on finding predictive factors and developing prognostic models for acute-on-chronic liver disease (AoCLD) caused by hepatitis B virus and alcohol consumption.
- Two nomograms, CATCH-LIFE A and CATCH-LIFE B, were created using data from two cohorts, showing strong abilities to predict 28-day and 90-day mortality rates.
- These nomograms can help in identifying high- and low-risk patients, potentially improving treatment strategies and survival outcomes for AoCLD patients.
PLOD1 promote proliferation and migration with glycolysis via the Wnt/β-catenin pathway in THCA.
Genomics
November 2024
Department of Thyroid Surgery, The Second Hospital of Shandong University, Shandong University, Shandong Province, PR China. Electronic address:
THCA (Thyroid carcinoma) is the most common endocrine malignancy in the world. The PLOD1 is highly expressed in THCA, but the mechanism is still unclear. It is found that the cell proliferation and migration were inhibited in si-PLOD1 group, and promoted with PLOD1 overexpression.
View Article and Find Full Text PDFThe PINK1/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia/reperfusion injury.
Pharmacol Res
November 2024
College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China. Electronic address:
Article Synopsis
- Myocardial ischemia/reperfusion injury (MIRI) causes significant heart damage due to restricted blood flow followed by restoration, leading to various harmful mechanisms like oxidative stress and inflammation.
- Abnormal mitochondrial function is a major factor in MIRI, with the PINK1/Parkin signaling pathway playing a key role in mitophagy, which helps maintain mitochondrial health.
- The review focuses on how this PINK1/Parkin pathway affects MIRI's pathological processes and explores potential interventions to improve mitochondrial function and reduce heart injury.
Construction and evaluation of a combined diagnostic model for chronic periprosthetic joint infection based on serological tests.
J Orthop Surg Res
October 2024
Department of Joint Surgery/Sports Medicine, The Second Hospital Of Shandong University, Jinan, 250033, China.
Background: Early diagnosis of chronic periprosthetic joint infection (CPJI) is crucial for ensuring effective treatment and improving patient outcomes. However, many auxiliary diagnostic tests are challenging to implement on a large scale due to economic and technical constraints, making CPJI diagnosis difficult. This study aims to design and validate a combined diagnostic model based on commonly used serological tests to evaluate its diagnostic value for CPJI and develop a diagnostic nomogram.
View Article and Find Full Text PDFA critical role for microglia in regulating metabolic homeostasis and neural repair after spinal cord injury.
Free Radic Biol Med
November 2024
Department of Orthopaedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China; Department of Orthopaedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; Shandong University Center for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; Department of Orthopedics, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. Electronic address:
Article Synopsis
- Traumatic spinal cord injury (SCI) can lead to immune and metabolic issues that worsen neurological damage and hinder recovery, and microglia are key immune cells in the spinal cord that help maintain health.
- This study investigates the role of microglia after SCI by depleting them, revealing that microglia support locomotor function recovery and are essential for glial scar formation, neurogenesis, and angiogenesis.
- The findings also show that microglial depletion disrupts lipid metabolism and increases oxidative stress in neurons, suggesting that microglia play a protective role against neural damage and metabolic disorders following SCI.
Targeting VPS18 hampers retromer trafficking of PD-L1 and augments immunotherapy.
Sci Adv
October 2024
Key Laboratory of Natural Products & Chemical Biology of Ministry of Education, Institute of Medical Sciences, The Second Hospital of Shandong University, Jinan, China.
Article Synopsis
- Immune checkpoint inhibitors that target PD-1 and PD-L1 show great potential in cancer treatment, but many patients exhibit limited responses due to insufficient understanding of how PD-L1 is regulated.
- The study reveals that VPS11 and VPS18 proteins play a crucial role in regulating PD-L1 by affecting its stability and recycling in cells, which impacts the effectiveness of immune therapies.
- The research suggests that using a drug called RDN, which inhibits VPS18, may improve cancer treatment outcomes when combined with existing therapies, especially in aggressive tumors, offering a new strategy to boost immune response against cancer.
Ultrasonography-guided canal decompression combined with vertebroplasty and cement-augmented pedicle screw fixation for stage III Kümmell's disease with neurological deficits: a retrospective cohort study.
BMC Musculoskelet Disord
October 2024
Department of Spine Surgery, The Second Hospital of Shandong University, 247 Beiyuan Road, Jinan, 250033, Shandong, China.
Article Synopsis
- The study examines the effectiveness of a new procedure combining ultrasonography-guided canal decompression, vertebroplasty, and cement-augmented pedicle screw fixation in treating stage III Kümmell's disease, particularly for patients with neurological deficits.
- Researchers reviewed data from eleven patients who underwent this procedure, recording surgery details and assessing outcomes through various measurements, including pain levels and spinal alignment.
- Results showed significant improvements in patient conditions post-surgery, suggesting that this combined approach is a safe and effective option for managing advanced cases of Kümmell's disease.
Multimodal apparent diffusion MRI model in noninvasive evaluation of breast cancer and Ki-67 expression.
Cancer Imaging
October 2024
Department of Radiology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, Shandong, China.
Article Synopsis
- - The study investigates how multimodal apparent diffusion (MAD) weighted MRI can differentiate between malignant and benign breast lesions, as well as predict Ki-67 expression levels in breast cancer patients.
- - In a sample of 93 patients, MAD imaging yielded significant differences in parameters between lesion types, with combined parameters showing improved diagnostic performance (AUC of 0.851 for malignancy and 0.691 for Ki-67 levels).
- - Results suggest that MAD weighted MRI is effective for diagnosing breast lesions and predicting Ki-67 expression, which can aid in treatment planning.
Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance.
Int J Endocrinol
October 2024
Shandong University, Cheeloo College of Medicine, Jinan, Shandong, China.
Article Synopsis
- The study aimed to explore the impact of TSH suppressive therapy on short-term depression and anxiety in patients with differentiated thyroid cancer (DTC) post-surgery.
- Conducted with 831 patients, the research found significant reductions in anxiety and depression levels three months after surgery, with various factors like educational background and tumor characteristics being influential.
- It concluded that TSH suppression therapy plays a crucial role in alleviating cancer-related anxiety and depression, with lower TSH levels correlating with worsening anxiety and depression scores.
Efficacy and safety of HAIC-FOLFOX plus tyrosine kinase inhibitors and immune checkpoint inhibitors as first-line treatment for unresectable advanced hepatocellular carcinoma: A systematic review and meta-analysis.
Acad Radiol
October 2024
The Institute of Interventional Oncology, Shandong University, Jinan CN-250033, PR China (P.J., C.C., J.T., B.L.); Department of Interventional Medicine and Minimally Invasive Oncology, The Second Hospital of Shandong University, Jinan CN-250033, PR China (C.C., J.T., B.L.). Electronic address:
Background: Advanced hepatocellular carcinoma (HCC) has been treated with targeted therapy, immunotherapy, or a combination of both, however, the overall clinical efficacy is still unsatisfactory. Hepatic arterial infusion chemotherapy (HAIC), as a localized treatment modality, has demonstrated favorable therapeutic efficacy in patients with advanced HCC accompanied by portal vein tumor thrombus and extensive intrahepatic metastasis. In recent years, the combination of HAIC with immune and targeted therapy has gradually gained acceptance in East Asian countries.
View Article and Find Full Text PDFSurgical interventions for degenerative lumbar spinal stenosis: a systematic review with network meta-analysis.
BMC Med
October 2024
The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Article Synopsis
- There are various surgical options for treating degenerative lumbar spinal stenosis (LSS), but current guidelines don't specify which should be prioritized due to past studies lacking in convincing evidence.
- A systematic review included 43 randomized controlled trials (RCTs) with over 5,000 participants, evaluating different surgical interventions, focusing on their impacts on physical function and adverse events.
- Results showed that endoscopic-assisted laminotomy and laminectomy with Coflex had small effects on physical function in the short term, while longer-term outcomes were varied, with some surgeries linked to fewer adverse effects compared to traditional laminectomy.
[Opportunities and challenges in the development of artificial intelligence research in spinal surgery].
Zhonghua Yi Xue Za Zhi
October 2024
Department of Orthopedics of the Second Hospital of Shandong University, Department of Orthopedics of Qilu Hospital, Shandong University Center for Orthopedics, International Science and Technology Cooperation Base of Spinal Cord Injury, Jinan 250033, China.
Artificial intelligence has emerged as a game-changer in the field of spine surgery, offering transformative diagnostic and therapeutic approaches for spinal conditions. The application of AI in spine research encompasses a diverse range of diseases, with usage scenarios becoming increasingly widespread and technological integration going deeper. AI technology shows immense promise and value in the diagnosis of spinal diseases, the formulation of treatment strategies, surgical navigation, prognostic evaluation, and postoperative rehabilitation.
View Article and Find Full Text PDF[Percutaneous transhepatic papillary balloon dilation combined with dual-frequency double-pulse laser lithotripsy for large-diameter common bile duct stones].
Zhonghua Nei Ke Za Zhi
October 2024
Department of Interventional and Minimally Invasive Oncology Therapy, the Second Hospital of Shandong University, Qilu Medical College, Shandong University, Jinan 250033, China.
To evaluate the safety and efficacy of percutaneous transhepatic papillary balloon dilation (PTPBD) combined with flexible ureteroscopy-guided dual-frequency double-pulse ND:YAG (FREDDY) laser lithotripsy (PTPBD-FREDDY) for the treatment of giant (>1.5 cm diameter) common bile duct stones. A retrospective analysis was conducted on 26 patients with large-diameter difficult choledocholithiasis admitted to two medical centers from December 2017 to October 2021.
View Article and Find Full Text PDFCausality between Telomere Length and the Risk of Hematologic Malignancies: A Bidirectional Mendelian Randomization Study.
Cancer Res Commun
October 2024
Department of Medical Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Article Synopsis
- Research indicates that telomere length (TL) may be linked to the risk and prognosis of hematologic cancers, but previous studies have had limitations that make this connection unclear.
- A two-sample Mendelian Randomization (MR) analysis was performed using genome-wide association study data, employing various methods to ensure reliability in results.
- The study found that longer telomeres are associated with a higher risk of several specific cancers, including acute and chronic lymphocytic leukemia, multiple myeloma, and lymphomas, suggesting that TL could play a role in assessing and managing these diseases.