Inhibition of STAT1 sensitizes radioresistant nasopharyngeal carcinoma cell line CNE-2R to radiotherapy.

Radioresistance remains a major obstacle for clinicians in the treatment of nasopharyngeal carcinoma (NPC). Others and we have reported that signal transducer and activator of transcription 1 (STAT1) may be as an important gene for resistance to radiation. However, the relationship between STAT1 and radioresistance is still elusive.

[Clinical analysis of radionuclide bone scan in patients with facial asymmetry].

Purpose: To study the radionuclide distribution in mandible of patients with facial asymmetry and help to select proper time and type of treatment.

Methods: The control group included 29 people with no facial asymmetry, while the experimental group consist of 207 patients with facial asymmetry. The radioactive count in 29 normal controls and 207 patients with facial asymmetry were measured and compared using 99mTc-MDP intake percentage in mandibular condyle, ramus and body.

Prohibitin is overexpressed in Huh-7-HCV and Huh-7.5-HCV cells harboring in vitro transcribed full-length hepatitis C virus RNA.

Background: Currently, up-regulated proteins and apoptosis in hepatitis C is a hot topic in exploring the pathogenic mechanism of Heptitis C Virus(HCV). Some recent studies shows that prohibitin is overexpressed in cells expressing HCV core proteins, and up-regulated prohibitin is also found in human hepatoma cell line HCC-M, lung cancer, prostate cancer, and other cancers. Prohibitin is an important member of the membrane protein superfamily, and it plays a role of molecular chaperones in mitochondrial protein stability.