1,466 results match your criteria: "the Second Affiliated Hospital of Kunming Medical University[Affiliation]"
BMC Med Genomics
December 2024
Department of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, 374# Dianmian Road, Kunming, Yunnan, 650101, P.R. China.
Background: Our previous study demonstrated that temperature-related microwave ablation (MWA) can safely modulate growth plates of piglets' vertebrae. Therefore, this study is designed to investigate the effects of different temperatures on chondrocyte viability and the underlying molecular mechanisms in vitro.
Methods: Following a 10-minute treatment at different temperatures (37 °C, 40 °C, 42 °C, 44 °C, 46 °C, 48 °C, and 50 °C), CCK-8 assay was used to examine the viability of ATDC5 cells at 12 h.
Blood Cancer J
December 2024
Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
To compare the efficacy and safety of gecacitinib (also known as jaktinib) with hydroxyurea (HU) in treating myelofibrosis (MF) patients. In this multicenter, randomized phase 3 trial (ZGJAK016), intermediate- or high-risk primarily JAK inhibitor naïve MF patients were assigned in a 2:1 ratio to receive either gecacitinib (100 mg twice a day, BID) or HU (500 mg BID). The primary endpoint was the proportion of patients with ≥35% reduction in spleen volume (SVR35) from baseline at week 24.
View Article and Find Full Text PDFZhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
December 2024
Faculty of Mechanical and Electrical Engineering, Kunming University of Science and Technology, Kunming Yunnan, 650504, P. R. China.
Objective: To establish a finite element model of the knee joint based on coronal plane alignment of the knee (CPAK) typing method, and analyze the biomechanical characteristics of different types of knee joints.
Methods: The finite element models of the knee joint were established based on CT scan data of 6 healthy volunteers. There were 5 males and 1 female with an average age of 24.
An Bras Dermatol
December 2024
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. Electronic address:
Background: Conventional systemic corticosteroid therapy for bullous pemphigoid (BP) has been challenged due to severe adverse events. Dupilumab has emerged as an alternative therapeutical option of BP patients.
Objectives: To evaluate the efficacy of dupilumab monotherapy and the combination with medium/low-dose corticosteroids for BP treatment.
Medicine (Baltimore)
December 2024
Department of General Surgery, Nujiang Prefecture People's Hospital, Nujiang, Yunnan, China.
Rationale: Low-grade appendiceal mucinous neoplasm (LAMN) is a clinically rare tumor that predominantly occurs in females and presents with nonspecific symptoms, often resulting in misdiagnosis. While postoperative pathology remains the gold standard for diagnosis, accurate preoperative identification through various diagnostic methods is essential for effective treatment planning. To raise awareness of this condition, we present a case of a middle-aged male diagnosed with LAMN.
View Article and Find Full Text PDFOncol Rep
February 2025
Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
The global incidence of prostate cancer (PCa) is rising. Localized PCa can be managed through surgical intervention or radiotherapy, but certain patients may experience recurrence or develop metastatic disease following localized treatment. Despite aggressive therapeutic approaches, the majority of metastatic patients with PCa will eventually progress to metastatic castration‑resistant PCa, with limited treatment alternatives and a dismal prognosis.
View Article and Find Full Text PDFAsian J Surg
December 2024
Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China. Electronic address:
World J Gastrointest Surg
November 2024
Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
Background: Asplenia-type heterotaxy syndrome (HS) is rare and refers to visceral malposition and dysmorphism. It is associated with a high infant mortality rate due to cardiac anomalies, and related digestive endoscopic interventions are poorly understood. With the improved long-term prognosis of these individuals after modern cardiac surgery, intra-abdominal anomalies have become increasingly significant.
View Article and Find Full Text PDFEur J Radiol
November 2024
Department of Radiology, Yan an Hospital of Kunming City (Yanan Hospital Affiliated to Kunming Medical University), 245 Renmin East Road, Kunming, Yunnan, China. Electronic address:
Background: Leveraging the radiomics information from non-small cell lung cancer (NSCLC) primary lesion and brain metastasis (BM) to develop and validate a bimodal radiomics nomogram that can accurately predict epidermal growth factor receptor (EGFR) status.
Methods: A total of 309 NSCLC patients with BM from three independent centers were recruited. Among them, the patients of Center I were randomly allocated into the training and internal test cohorts in a 7:3 ratio.
Adv Clin Exp Med
December 2024
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Kunming Medical University, China.
Turk J Gastroenterol
November 2024
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Background/aims: Studies have shown the significance of long non-coding RNAs (lncRNAs) in the development of malignant tumors, including cholangiocarcinoma (CCA). However, the molecular mechanisms through which the lncRNA SNHG3 contributes to CCA development remain unknown. Therefore, the purpose of this work was to investigate SNHG3's role and possible processes in CCA.
View Article and Find Full Text PDFHeliyon
November 2024
Department of Medical Oncology, The Second Affiliated Hospital of Kunming Medical University, 374 Dianmian Avenue, Wuhua District, Kunming, 650101, Yunnan, China.
Asian J Surg
December 2024
Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, China. Electronic address:
Bioact Mater
March 2025
Department of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, PR China.
Asian J Surg
November 2024
The Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, PR China. Electronic address:
Medicine (Baltimore)
November 2024
Department of Ophthalmology Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
Zhonghua Wai Ke Za Zhi
December 2024
Department of Cerebrovascular Disease, the Second Affiliated Hospital of Kunming Medical University,Kunming650101, China.
To study the feasibility of domestic flow diverter(TFD) for the treatment of unruptured internal carotid artery small- and medium-sized wide-neck aneurysms. This is a retrospective case series study.The study retrospectively evaluated consecutive 54 patients with unruptured intracranial small- and medium-sized wide-neck aneurysms treated with TFD in the Department of Cerebrovascular Disease,the Second Affiliated Hospital of Kunming Medical University between October 2019 and January 2024.
View Article and Find Full Text PDFBiomark Med
December 2024
Department of Medical Oncology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, P.R. China.
We aimed to investigate whether there is a correlation between AT and pleural effusion in PE patients. We retrospectively enrolled 325 patients aged 66.26 ± 14.
View Article and Find Full Text PDFOrphanet J Rare Dis
November 2024
Department of Dermatology, Haikou Branch hospital of the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650014, China.
Background: The underlying pathogenesis of pemphigus vulgaris, an autoimmune skin disorder, remains incompletely understood. An integrative analysis comprising DNA methylation, mRNA expression, and proteomic data in patients with pemphigus vulgaris was conducted to identify potential pathogenic contributors and explore the molecular mechanisms involved in its pathogenesis.
Results: The analysis revealed differentially methylated regions (DMRs) in the promoter, exon, intron, and downstream regions in the peripheral blood DNA of patients with pemphigus vulgaris.
J Biochem Mol Toxicol
December 2024
Department of Psychiatry, the Second Affiliated Hospital of Kunming Medical University, Kunming, China.
Atherosclerosis (AS) is a chronic multifactorial disease with damage to vascular endothelial cells (VECs). This study sought to delve into the mechanism of methyltransferase-like 14 (METTL14) in iron overload-induced lipid peroxidative damage in AS. AS mouse model and cell model were established.
View Article and Find Full Text PDFAsian J Surg
November 2024
Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, PR China. Electronic address:
Lancet Neurol
December 2024
Department of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.
Cytotechnology
February 2025
Oncology Department, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, 120 Guanghua Street, Kunming, 650200 Yunnan China.
Cervical cancer is one of the most common tumors in women and is a major problem in gynecological health. Studies have shown that Yinjia pills (YJP), a traditional Chinese medicine, can effectively slow the progression of cervical cancer. Therefore, this study mainly explored the molecular mechanism by which YJP delays the progression of cervical cancer.
View Article and Find Full Text PDFResearch (Wash D C)
November 2024
Department of Anesthesiology, Research Institute of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Tree shrews (TSs) possess a highly developed visual system. Here, we establish an age-related single-cell RNA sequencing atlas of retina cells from 15 TSs, covering 6 major retina cell classes and 3 glial cell types. An age effect is observed on the cell subset composition and gene expression pattern.
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