Safety and Efficacy of Multiple Escalating Doses of RC28-E for Neovascular Age-Related Macular Degeneration: A Phase 1b Trial.

Introduction: To assess the safety and efficacy of repeated intravitreal injections of RC28-E, a novel bispecific antibody that simultaneously binds vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with neovascular age-related macular degeneration (AMD). This was a prospective, multicenter, open-label clinical trial; 37 patients with choroidal neovascularization secondary to AMD and best-corrected visual acuity (BCVA) letter scores between 73 and 34 were enrolled.

Methods: Treatment regimens consisted of a 3-month loading phase and a pro re nata (PRN) maintenance phase.

Resectoscopic ablation of the gallbladder mucosa after cholecystostomy.

Purpose: To investigate the feasibility of endoscopic ablation of the gallbladder mucosa after cholecystostomy.

Materials And Methods: The mucosa of the gallbladder was endoscopically electrocoagulated through the cholecystostomy tract. After ablation, repeated luminal irrigation with chymotrypsin solution was given before removal of the tube.

Two-port laparoscopic cholecystectomy with modified suture retraction of the fundus: A practical approach.

Context: Although transumbilical single incision laparoscopic cholecystectomy (SILC) has been demonstrated to be superior cosmetic, it is only limited to simple cases at present. In complex cases, the standard four- or three-port LC is still the treatment of choice.

Aim: To summarize the clinical effect of a modified technique in two-port LC.