7 results match your criteria: "the People's Hospital of HongHuaGang District of ZunYi[Affiliation]"
Efficacy and safety of compound porcine cerebroside and ganglioside injection (CPCGI) versus piracetam on cognition and functional outcomes for adults with traumatic brain injury: A study protocol for randomized controlled trial.
Heliyon
September 2024
Department of Neurosurgery, Tianjin Neurological Institute, State Key Laboratory of Experimental Hematology, Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous System Tianjin & Ministry of Education, Tianjin Medical University General Hospital, Tianjin, China.
Article Synopsis
- - The study investigates the effectiveness and safety of compound porcine cerebroside and ganglioside injection (CPCGI) in improving cognitive and functional outcomes in patients with mild to moderate traumatic brain injury (TBI).
- - It is a multicenter, randomized, double-blind trial involving 900 adult patients, with 600 receiving CPCGI and 300 receiving piracetam as a control, followed by a 3-month evaluation period.
- - The primary goal is to assess changes in cognitive function using the Montreal Cognitive Assessment (MoCA) score, along with secondary measures like MMSE, GOS-E, and the Barthel Index.
Effect of l-oxiracetam and oxiracetam on memory and cognitive impairment in mild-to-moderate traumatic brain injury patients: Study protocol for a randomized controlled trial.
Aging Med (Milton)
June 2024
Department of Neurosurgery Tianjin Neurological Institute, State Key Laboratory of Experimental Hematology, Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous System Tianjin & Ministry of Education, Tianjin Medical University General Hospital Tianjin China.
Article Synopsis
- * A multicenter, randomized, double-blind clinical trial involving 590 TBI patients will compare the effects of l-oxiracetam, oxiracetam, and a placebo over a 14-day treatment period, followed by 90 days of observation.
- * Preliminary results indicate a lack of strong evidence supporting the cognitive-enhancing effects of these drugs on TBI patients, highlighting the importance of this research in addressing a significant clinical question.
Exploring the causal role of immune cells in cerebral aneurysm through single-cell transcriptomics and Mendelian randomization analysis.
Clin Exp Immunol
July 2024
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Article Synopsis
- Cerebral aneurysm (CA) is a serious medical condition involving the abnormal widening of brain arteries, and recent research highlights the important role of immune cells in its development.* -
- This study utilized single-cell RNA sequencing to understand how immune cell populations change in unruptured CA compared to controls, showing a trend towards inflammation as vascular smooth muscle cells decrease.* -
- Through Mendelian randomization analysis, specific immune cell types were identified as both risk factors and protective elements for CA, indicating a complex relationship between the immune system and CA progression that could inform future treatments.*
Multimodality management for chronic subdural hematoma in China: protocol and characteristics of an ambidirectional, nationwide, multicenter registry study.
Chin Neurosurg J
January 2024
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Background: Despite its prevalence, there is ongoing debate regarding the optimal management strategy for chronic subdural hematoma (CSDH), reflecting the variability in clinical presentation and treatment outcomes. This ambidirectional, nationwide, multicenter registry study aims to assess the efficacy and safety of multimodality treatment approaches for CSDH in the Chinese population.
Methods/design: A multicenter cohort of CSDH patients from 59 participating hospitals in mainland China was enrolled in this study.
DNA5mC Regulator-Mediated Molecular Clusters and Tumor Microenvironment Signatures in Glioblastoma.
Front Cell Dev Biol
November 2022
Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Article Synopsis
- - The study investigates the relationship between DNA methylation (5 mC) and tumor immunity specifically in glioblastoma patients using gene expression data from TCGA-GBM.
- - It reveals that different glioblastoma subtypes have unique DNA methylation and tumor microenvironment patterns, leading to the development of a DNA methylation score (DMS) which helps predict prognosis.
- - High DMS is correlated with better survival rates and improved effectiveness of immunotherapy, suggesting that understanding DNA methylation mechanisms could be crucial for glioblastoma treatment strategies.
Establishment and Validation of a Prognostic Immune Signature in Neuroblastoma.
Cancer Control
January 2022
Department of Cerebrovascular Disease, 66367Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Article Synopsis
- Neuroblastoma (NBL) is a common childhood tumor with a poor prognosis in high-risk patients, highlighting the need for better immunotherapy strategies through immune landscape profiling.
- A study established an Immune-related Prognostic Gene Pairs for Neuroblastoma (IPGPN) using RNA-seq data, identifying seven gene pairs that can stratify patients into high and low immune-risk groups based on overall survival.
- The findings suggest that incorporating immune-related genes with clinical data can enhance prognosis prediction, showing that patients with a low immune-risk profile have more favorable outcomes and specific immune cell enrichments.
Exosomal miR-199a-5p derived from endothelial cells attenuates apoptosis and inflammation in neural cells by inhibiting endoplasmic reticulum stress.
Brain Res
January 2020
Clinical Research Center for Neurological Disease, the People's Hospital of HongHuaGang District of ZunYi, China.
Remote ischemic post-conditioning (RIPostC) is a technique that can protect vital organs in an indirect manner, the effects of which are exerted by the long-distance exosome-mediated transfer of functional factors. In the current study, the possible mechanism driving the function of RIPostC was explored using an in vitro system by focusing on miR-199a-5p and its downstream effectors involved in endoplasmic reticulum (ER) stress. Human umbilical vein endothelial cells (HUVECs) were administrated with hypoxia/re-oxygenation (H/R) process and exosomes were collected from the H/R-treated HUVECs.
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