2 results match your criteria: "the Paediatric Academy of University of South China Changsha[Affiliation]"
Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression.
Histol Histopathol
May 2023
Department of Urology, Hunan Children's Hospital, the Paediatric Academy of University of South China Changsha, Hunan, PR China.
Background: Circular RNA (circRNA) has been shown to play an essential role in cancer progression, including nephroblastoma. Hsa_circ_0093741 was discovered to be highly expressed in nephroblastoma. However, its function and mechanism in nephroblastoma development are still vague.
View Article and Find Full Text PDFLong noncoding RNA DLEU2 regulates the progression of Wilm's tumor via miR-539-3p/HOXB2 axis.
J Pediatr Urol
February 2023
Department of Urology, Hunan Children's Hospital, The Paediatric Academy of University of South China Changsha, Hunan, 410007, PR China.
Article Synopsis
- Wilm's tumor is a common kidney cancer in children, and the study focuses on the role of DLEU2, a long noncoding RNA, in its progression.
- The research utilized various assays to explore how DLEU2 affects cancer cell behaviors like proliferation and invasion, revealing that silencing DLEU2 led to reduced tumor cell activity and increased cell death.
- Results showed that DLEU2 positively regulates HOXB2 by inhibiting miR-539-3p, suggesting a mechanism that promotes Wilm's tumor malignancy and indicating potential therapeutic targets.