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Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein.
Free Radic Biol Med
September 2003
The Research Service, Stratton Veterans Affairs Medical Center, the Ordway Research Institute and the Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
DSCR1 (adapt78) is a stress-inducible gene and cytoprotectant. Its protein product, DSCR1 (Adapt78), also referred to as MCIP1, inhibits intracellular calcineurin, a phosphatase that mediates many cellular responses to calcium. Exposure of human U251 and HeLa cells to hydrogen peroxide led to a rapid hyperphosphorylation of DSCR1 (Adapt78).
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