Out of area placements for people with "Personality Disorder": Making the case for a local intensive psychotherapeutic alternative.

Objectives: The use of Out of Area (OoA) psychiatric placements for people with "Personality Disorder" (PD) is widespread in the UK. An innovative local intensive psychotherapeutic service, adapted to the transdiagnostic presentations of the most complex PD patients, likely to be placed out of the area, was devised in the English County of Devon. This paper reports the findings of a Freedom of Information (FOI) request to commissioners attempting to quantify PD OoA placements in England and the cost offset of the local therapeutic alternative to OoA placements in Devon.

The Roles of Transient Receptor Potential (TRP) Channels Underlying Aberrant Calcium Signaling in Blood-Retinal Barrier Dysfunction.

The inner blood-retinal barrier (iBRB) protects the retinal vasculature from the peripheral circulation. Endothelial cells (ECs) are the core component of the iBRB; their close apposition and linkage via tight junctions limit the passage of fluids, proteins, and cells from the bloodstream to the parenchyma. Dysfunction of the iBRB is a hallmark of many retinal disorders.

A Low Albedo, Thin, Resistant Unit in Oxia Planum, Mars: Evidence for an Airfall Deposit and Late-Stage Groundwater Activity at the ExoMars Rover Landing Site.

Oxia Planum, Mars, is the future landing site of the ExoMars rover mission, which will search for preserved biosignatures in a phyllosilicate-bearing unit. Overlying the mission-important phyllosilicate-bearing rocks is a dark, capping unit-known here as the Low albedo, Thin, Resistant (LTR) unit-which may have protected the phyllosilicate-bearing unit over geologic time from solar insolation and radiation. However, little is known about the origin of the LTR unit.

Application of High-pressure Carbon Dioxide in Japanese Anchovy Waste Recycling by Enzymatic Hydrolysis.

Anchovy waste, a protein resource with high nutritional value and potential for recycling with a relatively high economic effect, is essential for the Sustainable Development Goals of the United Nations. Preventing microbial contamination during the recycling process, through enzymatic hydrolysis, ensures the safety of recycled products. High-pressure carbon dioxide is a novel non-thermal decontamination technology, which inactivates cells by breaking their membranes.

Feasibility of implementing a communication board to improve communication interactions of mechanically ventilated patients in intensive care units at one Sri Lankan hospital - A pilot randomised controlled trial.

Objective: To evaluate the feasibility of implementing a communication board in intensive care units in terms of participant recruitment and retention, intervention fidelity, and ability to collect patient outcome data.

Design: A prospective, two-arm, unblinded, pilot randomised controlled trial.

Research Methodology: Adult, conscious, mechanically ventilated intensive care patients were recruited between August and November 2023.

Transitions-Related Support for Ageing Family Carers of Older People With Intellectual Disabilities Who Convey Behaviours That Challenge Others: A Systematic Rapid Scoping Review.

Background: There are increasing numbers of ageing family carers of older (40+) adults with intellectual disabilities who convey behaviours that challenge others in the UK. It is important to understand the needs and experiences of these carers as they support their older family member to transition to different care contexts.

Method: A rapid scoping review of published and unpublished literature, using systematic methods of data searching, extraction and analysis.

Hybrid particle-phase field model and renormalized surface tension in dilute suspensions of nanoparticles.

We present a two-phase field model and a hybrid particle-phase field model to simulate dilute colloidal sedimentation and flotation near a liquid-gas interface (or fluid-fluid interface in general). Both models are coupled to the incompressible Stokes equation, which is solved numerically using a combination of sine and regular Fourier transforms to account for the no-slip boundary conditions at the boundaries. The continuum two-phase field model allows us to analytically solve the equilibrium interfacial profile using a perturbative approach, demonstrating excellent agreement with numerical simulations.

Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation.

Most neural prosthetic devices are based on electrical stimulation, although the modulation of neuronal activity by a localized chemical delivery would better mimic physiological synaptic machinery. In the past decade, various drug delivery approaches attempted to emulate synaptic transmission, although they were hampered by poor retention of their cargo while reaching the target destination, low spatial resolution, and poor biocompatibility and stability of the materials involved. Here, we propose a planar solid-state device for multisite neurotransmitter translocation at the nanoscale consisting of a nanopatterned ceramic membrane connected to a reservoir designed to store neurotransmitters.

Integrated bioinformatics and machine learning algorithms reveal the unfolded protein response pathways and immune infiltration in acute myocardial infarction.

Background: The unfolded protein response (UPR) is a critical biological process related to a variety of physiological functions and cardiac disease. However, the role of UPR-related genes in acute myocardial infarction (AMI) has not been well characterized. Therefore, this study aims to elucidate the mechanism and role of the UPR in the context of AMI.

Visual hallucinations in psychosis: What do people actually see?

Background: One in three people with psychosis experience visions. However, little is known about what people see, and current treatments have limited benefits.

Objectives: To improve the understanding and treatment of visions, this study explored the phenomenology of visions in people with psychosis.

Gratitude and Subjective Well-Being in Older Chinese Adults in Nursing Homes: The Mediating Roles of Self-Efficacy and Social Support.

Aim: With an aging global population, there has been a growing interest in the subjective well-being (SWB) of older people. As a positive emotion, gratitude has been found to be significantly and positively associated with SWB. However, the mechanisms underlying the relationship between gratitude and SWB remain poorly understood.

Hospice topophilia and topophobia as experienced by a local population: Implications for equity of access.

The examination of hospice settings from the position of space and place is an emerging area of academic interest. Engaging with this perspective, this paper explores how topophilia and topophobia of the physical hospice setting coincides with and informs a broader love and fear of hospice care and UK hospice organisations. We report the findings of a qualitative study of 53 participants in the catchment population of a hospice in England.

Thermal Rates and High-Temperature Tunneling from Surface Reaction Dynamics and First-Principles.

Studying dynamics of the dissociative adsorption and recombinative desorption of hydrogen on copper surfaces has shaped our atomic-scale understanding of surface chemistry, yet experimentally determining the thermal rates for these processes, which dictate the outcome of catalytic reactions, has been impossible so far. In this work, we determine the thermal rate constants for dissociative adsorption and recombinative desorption of hydrogen on Cu(111) between 200 and 1000 K using data from reaction dynamics experiments. Contrary to current understanding, our findings demonstrate the predominant role of quantum tunneling, even at temperatures as high as 400 K.

The sustainable challenge: Where does social psychology stand in achieving the sustainable development goals?

The United Nations Agenda 2030, inclusive of its 17 sustainable development goals (SDGs), serves as the global blueprint for sustainability for both present and future generations. Scientific research is entrusted with the responsibility of contributing by informing the current situation and future challenges in achieving the SDGs. This paper investigates the role of social psychology in contributing to the SDGs and the environmental, economic and social pillars of the UN Agenda.

Competing Bifurcations Determine Symmetry Breaking During Droplet Snaps on Smooth Patterned Surfaces.

The shape and stability of a droplet in contact with a solid surface is affected by the chemical composition and topography of the solid, and crucially, by the droplet's size. During a variation in size, most often observed during evaporation, droplets on smooth patterned surfaces can undergo sudden shape and position changes. Such changes, called snaps, are prompted by the surface pattern and arise from fold and pitchfork bifurcations which respectively cause symmetric and asymmetric motions.

Intensification of a rain system imparted by Mediterranean mesoscale eddies.

Ocean mesoscale eddies, with km size, present in energetic regions of the global ocean, are known to impact local and remote atmospheric weather. The impact of eddies in the Mediterranean Sea on the local weather, however, remains largely unknown. Here, we study this impact during an extreme weather event observed over Israel on January , 2020, resulting in heavy rains and floods.

Emotional stimuli boost incidental learning through predictive processing.

Extracting regularities and probabilities from the environment is a fundamental and critical ability in an ever-changing surrounding. Previous findings showed that people are highly efficient in learning these regularities and that emotional stimuli are better learned than neutral ones. Yet, the generality and the underlying mechanism of this benefit are poorly understood.

Interatomic Coulombic electron capture beyond the virtual photon approximation.

Via the interatomic Coulombic electron capture (ICEC) process, an electron can be captured by an atom or a molecule, while the binding and excess energy is transferred, via a long-range Coulomb interaction, to a neighboring atom or molecule. The transferred energy can be used to ionize or electronically excite the neighboring species. When the two species are asymptotically far apart, an analytical formula for the ICEC cross sections can be derived.

Semantic-guided attention and adaptive gating for document-level relation extraction.

In natural language processing, document-level relation extraction is a complex task that aims to predict the relationships among entities by capturing contextual interactions from an unstructured document. Existing graph- and transformer-based models capture long-range relational facts across sentences. However, they still cannot fully exploit the semantic information from multiple interactive sentences, resulting in the exclusion of influential sentences for related entities.

Pharmaceutical applications of lignin-derived chemicals and lignin-based materials: linking lignin source and processing with clinical indication.

Lignocellulosic biomass is one of the most abundant bioresources on Earth. Over recent decades, various valorisation techniques have been developed to produce value-added products from the cellulosic and hemicellulosic fractions of this biomass. Lignin is the third major component accounting for 10-30% (w/w).

Postgenomic understandings of fatness and metabolism.

'Obesity' has, for decades, been a subject of intense scientific and public interest, and remains a key target for postgenomic science. I examine the emergence of determinism in research into 'obesity' in the postgenomic field of metabolomics. I argue that determinism appears in metabolomics research in two ways: firstly, fragmentation and narrow construal of the environment is evident in metabolomics studies on weight loss interventions, resulting in particular features of the environment (notably, dietary intake) having outsized influence while the wider social environment is neglected.