Effectiveness of work-based educational interventions for antimicrobial stewardship: a systematic review.

Background: The pressing need for better antimicrobial stewardship (AMS) is invariably reliant on educational interventions in some form.

Objectives: To evaluate the effectiveness of post-qualification educational interventions for AMS behaviour change among health professionals.

Methods: Seven databases were searched for articles published between 2013 and 2024 for post-qualification educational interventions aimed at health professionals to improve AMS.

Influencing children: food cues in YouTube content from child and youth influencers.

Digital marketing of unhealthy foods is linked to childhood obesity. This study evaluated nutrient quality and creative strategies of food cues on social media, focusing on child/youth influencers, to inform the ongoing digital media regulatory debate. Using the WHO's Monitoring of Marketing of Unhealthy Products to Children and Adolescents protocol, 162 videos from seven child/youth influencers' YouTube accounts with German content (33.

Quantum-inspired neural network with hierarchical entanglement embedding for matching.

Quantum-inspired neural networks (QNNs) have shown potential in capturing various non-classical phenomena in language understanding, e.g., the emgerent meaning of concept combinations, and represent a leap beyond conventional models in cognitive science.

Monocyte-derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF-β1.

During cell invasion, large Extracellular Vesicle (lEV) release from host cells was dose-dependently triggered by Trypanosoma cruzi metacyclic trypomastigotes (Mtr). This lEV release was inhibited when IP-mediated Ca exit from the ER and further Ca entry from plasma membrane channels was blocked, but whilst any store-independent Ca entry (SICE) could continue unabated. That lEV release was equally inhibited if all entry from external sources was blocked by chelation of external Ca points to the major contributor to Mtr-triggered host cell lEV release being IP/store-mediated Ca release, SICE playing a minor role.

Efficacy, safety, and immunogenicity of biosimilars compared with the biologic etanercept in patients with rheumatoid arthritis: a systematic review and meta-analysis.

Background: Biosimilar etanercept presents itself as an innovative therapeutic opportunity for inflammatory and autoimmune diseases, however, its efficacy, safety, and immunogenicity in relation to the reference biological agent for the treatment of rheumatoid arthritis is still questioned. With this in mind, this study aimed to verify the efficacy, safety, and immunogenicity of the use of the biosimilar etanercept in relation to the reference biologic in patients over 18 years of age with rheumatoid arthritis.

Methods: A systematic review with meta-analysis was performed in accordance with the parameters of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) selecting only Phase III randomized clinical trials.

Development of the Followership Evaluation Instrument for Nurses: A Prospective Longitudinal Survey.

Maintaining a healthy work environment in nursing practice depends not only on the leader's skill but also on the nursing staff's followership. The study purpose is to develop a followership instrument for nurses. We developed a followership evaluation instrument using data from two surveys conducted in 2013 and 2014 and assessed its validity using a questionnaire with nurses in Japan.

REST-dependent glioma progression occurs independently of the repression of the long non-coding RNA HAR1A.

The long non-coding RNA (lncRNA), HAR1A is emerging as a putative tumour suppressor. In non-neoplastic brain cells, REST suppresses HAR1A expression. In gliomas REST acts as an oncogene and is a potential therapeutic target.

Untargeted and Targeted Lipidomics Unveil Dynamic Lipid Metabolism Alterations in Type 2 Diabetes.

Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with a growing body of evidence suggesting the central role of lipid metabolism in its pathogenesis. However, the dynamic changes in lipid metabolism across different stages of T2DM remain understudied.

Objective: This study aimed to elucidate the temporal alterations in lipid metabolism in T2DM using an integrated lipidomics approach.

Out of area placements for people with "Personality Disorder": Making the case for a local intensive psychotherapeutic alternative.

Objectives: The use of Out of Area (OoA) psychiatric placements for people with "Personality Disorder" (PD) is widespread in the UK. An innovative local intensive psychotherapeutic service, adapted to the transdiagnostic presentations of the most complex PD patients, likely to be placed out of the area, was devised in the English County of Devon. This paper reports the findings of a Freedom of Information (FOI) request to commissioners attempting to quantify PD OoA placements in England and the cost offset of the local therapeutic alternative to OoA placements in Devon.

The Roles of Transient Receptor Potential (TRP) Channels Underlying Aberrant Calcium Signaling in Blood-Retinal Barrier Dysfunction.

The inner blood-retinal barrier (iBRB) protects the retinal vasculature from the peripheral circulation. Endothelial cells (ECs) are the core component of the iBRB; their close apposition and linkage via tight junctions limit the passage of fluids, proteins, and cells from the bloodstream to the parenchyma. Dysfunction of the iBRB is a hallmark of many retinal disorders.

A Low Albedo, Thin, Resistant Unit in Oxia Planum, Mars: Evidence for an Airfall Deposit and Late-Stage Groundwater Activity at the ExoMars Rover Landing Site.

Oxia Planum, Mars, is the future landing site of the ExoMars rover mission, which will search for preserved biosignatures in a phyllosilicate-bearing unit. Overlying the mission-important phyllosilicate-bearing rocks is a dark, capping unit-known here as the Low albedo, Thin, Resistant (LTR) unit-which may have protected the phyllosilicate-bearing unit over geologic time from solar insolation and radiation. However, little is known about the origin of the LTR unit.

Application of High-pressure Carbon Dioxide in Japanese Anchovy Waste Recycling by Enzymatic Hydrolysis.

Anchovy waste, a protein resource with high nutritional value and potential for recycling with a relatively high economic effect, is essential for the Sustainable Development Goals of the United Nations. Preventing microbial contamination during the recycling process, through enzymatic hydrolysis, ensures the safety of recycled products. High-pressure carbon dioxide is a novel non-thermal decontamination technology, which inactivates cells by breaking their membranes.

Feasibility of implementing a communication board to improve communication interactions of mechanically ventilated patients in intensive care units at one Sri Lankan hospital - A pilot randomised controlled trial.

Objective: To evaluate the feasibility of implementing a communication board in intensive care units in terms of participant recruitment and retention, intervention fidelity, and ability to collect patient outcome data.

Design: A prospective, two-arm, unblinded, pilot randomised controlled trial.

Research Methodology: Adult, conscious, mechanically ventilated intensive care patients were recruited between August and November 2023.

Transitions-Related Support for Ageing Family Carers of Older People With Intellectual Disabilities Who Convey Behaviours That Challenge Others: A Systematic Rapid Scoping Review.

Background: There are increasing numbers of ageing family carers of older (40+) adults with intellectual disabilities who convey behaviours that challenge others in the UK. It is important to understand the needs and experiences of these carers as they support their older family member to transition to different care contexts.

Method: A rapid scoping review of published and unpublished literature, using systematic methods of data searching, extraction and analysis.

Hybrid particle-phase field model and renormalized surface tension in dilute suspensions of nanoparticles.

We present a two-phase field model and a hybrid particle-phase field model to simulate dilute colloidal sedimentation and flotation near a liquid-gas interface (or fluid-fluid interface in general). Both models are coupled to the incompressible Stokes equation, which is solved numerically using a combination of sine and regular Fourier transforms to account for the no-slip boundary conditions at the boundaries. The continuum two-phase field model allows us to analytically solve the equilibrium interfacial profile using a perturbative approach, demonstrating excellent agreement with numerical simulations.

Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation.

Most neural prosthetic devices are based on electrical stimulation, although the modulation of neuronal activity by a localized chemical delivery would better mimic physiological synaptic machinery. In the past decade, various drug delivery approaches attempted to emulate synaptic transmission, although they were hampered by poor retention of their cargo while reaching the target destination, low spatial resolution, and poor biocompatibility and stability of the materials involved. Here, we propose a planar solid-state device for multisite neurotransmitter translocation at the nanoscale consisting of a nanopatterned ceramic membrane connected to a reservoir designed to store neurotransmitters.

Integrated bioinformatics and machine learning algorithms reveal the unfolded protein response pathways and immune infiltration in acute myocardial infarction.

Background: The unfolded protein response (UPR) is a critical biological process related to a variety of physiological functions and cardiac disease. However, the role of UPR-related genes in acute myocardial infarction (AMI) has not been well characterized. Therefore, this study aims to elucidate the mechanism and role of the UPR in the context of AMI.

Visual hallucinations in psychosis: What do people actually see?

Background: One in three people with psychosis experience visions. However, little is known about what people see, and current treatments have limited benefits.

Objectives: To improve the understanding and treatment of visions, this study explored the phenomenology of visions in people with psychosis.

Gratitude and Subjective Well-Being in Older Chinese Adults in Nursing Homes: The Mediating Roles of Self-Efficacy and Social Support.

Aim: With an aging global population, there has been a growing interest in the subjective well-being (SWB) of older people. As a positive emotion, gratitude has been found to be significantly and positively associated with SWB. However, the mechanisms underlying the relationship between gratitude and SWB remain poorly understood.

Hospice topophilia and topophobia as experienced by a local population: Implications for equity of access.

The examination of hospice settings from the position of space and place is an emerging area of academic interest. Engaging with this perspective, this paper explores how topophilia and topophobia of the physical hospice setting coincides with and informs a broader love and fear of hospice care and UK hospice organisations. We report the findings of a qualitative study of 53 participants in the catchment population of a hospice in England.