Exploring the effects of financial stress on undergraduate nursing students in Scotland.

The sharp increase in the cost of living in the UK over the past few years has affected all populations, including higher education students. Many higher education students, including nursing students, are experiencing financial difficulties and concerns, which adversely affect their mental health and can cause them to consider leaving their course. This article reports the findings of an online survey undertaken in one university in Glasgow, Scotland, that aimed to explore the effects of financial stress on second and third-year nursing students.

What does "sustainable seafood" mean to seafood system actors in Japan and Sweden?

"Sustainability" can mean different prioritisations of society, environment and economy to different people. As one of the largest globally traded food commodities, for seafood, these differences could have large implications. The study captures different understandings of "sustainable seafood" among 29 key actors along the seafood supply chain-government, NGOs, industry bodies, retailers and producers-using a novel cross-country application of Q method in Japan and Sweden.

Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface.

The placenta is the critical interface between mother and fetus, and consequently, placental dysfunction underlies many pregnancy complications. Placental formation requires an adequate expansion of trophoblast stem and progenitor cells followed by finely tuned lineage specification events. Here, using single-cell RNA sequencing of mouse trophoblast stem cells during the earliest phases of differentiation, we identify gatekeepers of the stem cell state, notably Nicol1, and uncover unsuspected trajectories of cell lineage diversification as well as regulators of lineage entry points.

Stereospecific Radical Bromination of ß-Aryl Alcohols with Thiourea Additives Through A Serendipitous Discovery of A 1,2-Aryl Migration.

The development of new protocols for stereospecific and stereoselective halogenation transformations by mild reaction conditions is a highly desirable research target for the chemical and pharmaceutical industries. Following the straightforward methodology for directly transforming a wide scope of alcohols to alkyl bromides and chlorides using substoichiometric amounts of thioureas and N-halo succinimides (NXS) as a halogen source in a single step, we noticed that in apolar solvents bromination of chiral secondary alcohols did not produce the expected racemates. In this study, the stereochemical aspects of the bromination reaction were examined.

Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins.

Background: TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor superfamily. TRAIL selectively induces apoptosis in tumor cells while sparing normal cells, which makes it an attractive candidate for cancer therapy. Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors have demonstrated safety and tolerability in clinical trials.

Multidisciplinary team meetings: dynamic routines that (re)make palliative care.

Multidisciplinary team meetings are part of the everyday working life of palliative care staff. Based on ethnographic material from community and hospital palliative care teams in England, this article examines these meetings as dynamic routines. Although intended to have a prescribed format to review deaths and collect standardised information to monitor service performance, in practice, the content and conduct of the meetings were fluid, reflecting how this structure did not always match the concerns held by the team.

Comparative evaluation of spatiotemporal methods for effective dengue cluster detection with a case study of national surveillance data in Thailand.

Dengue fever poses a significant public health burden in tropical regions, including Thailand, where periodic epidemics strain healthcare resources. Effective disease surveillance is essential for timely intervention and resource allocation. Various methods exist for spatiotemporal cluster detection, but their comparative performance remains unclear.

'Making abortion safe': abortion and post-abortion care providers' experiences of stigma in Rwanda, Zimbabwe, Sierra Leone and Nigeria.

Background: Social stigma and the marginalisation of abortion care within medical settings can negatively affect abortion providers. While some research has evaluated stigma interventions in legally restrictive settings, little work has explored the experiences of healthcare professionals (HCPs) providing abortion and post-abortion care (PAC) outside the USA. This study, part of the Royal College of Obstetricians and Gynaecologists' 'Making Abortion Safe' programme, aimed to understand providers' experiences of abortion stigma in four African countries with restrictive legislation.

ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation.

Essential for brain formation and protective against tauopathy, activity-dependent neuroprotective protein (ADNP) is critical for neurogenesis and cognitive functions, while regulating steroid hormone biogenesis. As such, de novo mutations in ADNP lead to syndromic autism and somatic ADNP mutations parallel Alzheimer's disease progression. Furthermore, clinical trials with the ADNP fragment NAP (the investigational drug davunetide) showed efficacy in women suffering from the tauopathy progressive supranuclear palsy and differentially boosted memory in men (spatial) and women (verbal), exhibiting prodromal Alzheimer's disease.

CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis.

Triple-negative breast cancer (TNBC) is an aggressive molecular subtype of breast cancer characterized by a high recurrence rate, poor prognosis, and elevated mortality. Identifying novel molecular targets is crucial for developing more effective therapeutic strategies against TNBC. Recent studies have highlighted the role of circular RNAs (circRNAs) in the progression of TNBC.

Systematic review of evidence for the impact and effectiveness of the 1-3-7 strategy for malaria elimination.

Background: The 1-3-7 approach to eliminate malaria was first implemented in China in 2012. It has since been expanded to multiple countries, but no systematic review has examined the evidence for its use. A systematic review was conducted aiming to evaluate the impact and effectiveness of the strategy and identify key challenges and variations in its implementation across different countries.

Large language models outperform general practitioners in identifying complex cases of childhood anxiety.

Objective: Anxiety is prevalent in childhood but often remains undiagnosed due to its physical manifestations and significant comorbidity. Despite the availability of effective treatments, including medication and psychotherapy, research indicates that physicians struggle to identify childhood anxiety, particularly in complex and challenging cases. This study aims to explore the potential effectiveness of artificial intelligence (AI) language models in diagnosing childhood anxiety compared to general practitioners (GPs).

Successful Aging across Middle vs High-Income Countries: An Analysis of the Role of eHealth Literacy Associated with Loneliness and Wellbeing.

Background And Objectives: "Successful aging" concerns the process of growing older while maintaining physical, cognitive, and social wellbeing, emphasizing independence for overall satisfaction and quality of life. We investigate the impact of e-health literacy on reducing loneliness and sustaining wellbeing during the pandemic, comparing middle- and high-income countries.

Research Design And Methods: Online surveys were conducted between April 4, 2020, and September 30, 2021, collecting responses (N=2091) from medium- and high-income countries in Europe, Asia, and North America.

PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans.

Dental morphology varies greatly throughout evolution, including in the human lineage, but little is known about the biology of this variation. Here, we use multiomics analyses to examine the genetics of variation in tooth crown dimensions. In a human cohort with mixed continental ancestry, we detected genome-wide significant associations at 18 genome regions.

The association of polytherapy and psychiatric comorbidity in epilepsy.

Purpose: Managing epilepsy may require using more than one anti-seizure medication (ASM). While combination therapy may help, risks, including psychiatric problems, are not fully explored in Africa. We examined the relationship between polytherapy and psychiatric comorbidities among attendees of an epilepsy community clinic.

Electrophysiology Reveals That Intuitive Physics Guides Visual Tracking and Working Memory.

Starting in early infancy, our perception and predictions are rooted in strong expectations about the behavior of everyday objects. These intuitive physics expectations have been demonstrated in numerous behavioral experiments, showing that even pre-verbal infants are surprised when something impossible happens (e.g.

Frequency, redundancy, and context in bilingual acquisition.

We report findings from a corpus-based investigation of three young children growing up in German-English bilingual environments ( = 3;0, Range = 2;3-3;11). Based on 2,146,179 single words and two-word combinations in naturalistic child speech (CS) and child-directed speech (CDS), we assessed the degree to which the frequency distribution of CDS predicted CS usage over time, and systematically identified CS that was over- or underrepresented in the corpus with respect to matched CDS baselines. Results showed that CDS explained 61% of the variance in CS single-word use and 19.

The impact of protocol designs for using massage guns on lower body flexibility: A randomised cross-over design study.

Introduction: Current protocols for delivering percussive therapy (PT) using massage guns are heterogeneous creating a need to establish the impact of study design on physiological measures. This cross-over design study aimed to determine the most effective protocol, among the eight protocols examined, on lower body flexibility, and to support the provision of protocol validation for future research.

Method: Recreationally active healthy adults (n = 35) undertook two main protocols; three sessions per week at 2100 rpm or increasing the speed from session-to-session: 1750 to 2100-2400 rpm.

Rethinking village malaria workers in Cambodia: Perspectives from the communities, programme managers, and international stakeholders.

Since the early 2000s, malaria cases in Cambodia have declined steadily. Village malaria workers (VMWs) have played a critical role in reducing malaria transmission and progress towards malaria elimination. To prevent malaria re-establishment, however, implementation strategies need to consider carefully the changing healthcare needs in the communities as well as challenges to, and opportunities for, programme adaptation.

Language in job advertisements and the reproduction of labor force gender and racial segregation.

Job advertisements (ads) represent the first point of contact between employers and job seekers. By signaling characteristics expected of an ideal candidate, job ads "gatekeep" the labor force and configure its composition. Meanwhile, labor force composition can also shape the wording of job ads.

Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model.

Biomaterials are widely used as orthopaedic implants and bone graft substitutes. We aimed to develop a rapid osteogenic assessment method using a murine tibial periosteal ossification model to evaluate the bone formation/remodelling potential of a biomaterial within 2-4 weeks. A novel hydroxyapatite/aragonite (HAA) biomaterial was implanted into C57BL/6 mice juxtaskeletally between the tibia and tibialis anterior muscle.

Effectiveness of work-based educational interventions for antimicrobial stewardship: a systematic review.

Background: The pressing need for better antimicrobial stewardship (AMS) is invariably reliant on educational interventions in some form.

Objectives: To evaluate the effectiveness of post-qualification educational interventions for AMS behaviour change among health professionals.

Methods: Seven databases were searched for articles published between 2013 and 2024 for post-qualification educational interventions aimed at health professionals to improve AMS.