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Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Treatment-Resistant Depression: A Randomized Clinical Trial.

JAMA Psychiatry

May 2016

Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands2Amsterdam Brain and Cognition, Amsterdam, the Netherlands10Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amste.

Importance: Patients with treatment-resistant depression (TRD) do not respond sufficiently to several consecutive treatments for major depressive disorder. Deep brain stimulation (DBS) is a promising treatment for these patients, but presently placebo effects cannot be ruled out.

Objective: To assess the efficacy of DBS of the ventral anterior limb of the internal capsule (vALIC), controlling for placebo effects with active and sham stimulation phases.

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