4 results match your criteria: "the Netherlands. Electronic address: m.eck@lacdr.leidenuniv.nl.[Affiliation]"
Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier.
Biochim Biophys Acta Mol Cell Biol Lipids
March 2020
Division BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Zuid-Holland, the Netherlands. Electronic address:
Article Synopsis
- Scavenger receptor class B type I (SR-BI) is crucial for the uptake of cholesteryl esters (CE) from HDL, and its dysfunction can lead to increased cholesterol in the bloodstream (hyperalphalipoproteinemia).
- In studies comparing wild-type and SR-BI knockout mice, the absence of SR-BI did not significantly change epidermal cholesterol but did alter free fatty acid (FFA) composition, indicating a response to elevated plasma cholesterol.
- The impaired SR-BI function resulted in a compromised epidermal lipid barrier, demonstrating that increased HDL-cholesterol levels can negatively affect skin lipid composition and barrier function similar to what is seen in high cholesterol situations.
Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.
Toxicol Appl Pharmacol
September 2016
Leiden Academic Centre for Drug Research, The Netherlands. Electronic address:
Cholestatic liver disease is characterized by a disruption of bile flow, bile acid toxicity, liver injury, and hypercholesterolemia. Relatively high secretion of glucocorticoids by the adrenals has been observed under cholestatic conditions. Here we investigated a contribution of the rise in endogenous glucocorticoids to initial stage cholestasis pathology.
View Article and Find Full Text PDFAbca1 deficiency protects the heart against myocardial infarction-induced injury.
Atherosclerosis
August 2016
Division of Biopharmaceutics, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands. Electronic address:
Background And Aims: We explored the role of ATP-binding cassette transporter A1 (Abca1), in post-myocardial infarction (MI) cardiac injury.
Methods: In Abca1(-/-) mice, wild type (WT) mice, and WT mice transplanted with Abca1(-/-) or WT bone marrow, an MI was induced in vivo. Furthermore, an ex vivo MI was induced in isolated Abca1(-/-) and WT hearts.
HDL subpopulations: of mice and men.
Atherosclerosis
March 2014
Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. Electronic address: