1 results match your criteria: "the Netherlands jwm.heemskerk@maastrichtuniversity.nl kd286@cam.ac.uk.[Affiliation]"
High-throughput elucidation of thrombus formation reveals sources of platelet function variability.
Haematologica
June 2019
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, the Netherlands
Article Synopsis
- Whole-blood microfluidics and microspotting techniques were used to analyze platelet functions involved in thrombus formation among 94 healthy individuals, focusing on inter- and intra-subject variability.
- Researchers evaluated 24 platelet parameters and identified key glycoproteins (GPs) and activation markers that influenced variations in platelet activation and thrombus characteristics.
- The study revealed that inter-subject variability in thrombus formation was significantly higher than intra-subject variability, with certain genetic factors and specific glycoprotein pathways (like GPVI) playing critical roles in platelet function differences among individuals.