685,105 results match your criteria: "the Netherlands; Research Center[Affiliation]"

Objectives: Health technology assessment (HTA) guidelines are intended to support the successful implementation of HTA by enhancing consistency and transparency in concepts, methods, processes, and use, thereby enhancing the legitimacy of the decision-making process. This report lays out good practices and practical recommendations for developing or updating HTA guidelines to ensure successful implementation.

Methods: The task force was established in 2022 and comprised experts and academics from various geographical regions, each with substantial experience in developing HTA guidelines for national health policy making.

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Aims: Sleep disordered breathing (SDB), lower urinary tract dysfunction (LUTD), and enuresis (NE) are common in children and adolescents and have serious consequences, especially on social and emotional development. Even though much is known about the association between SDB and NE among adults, the number of articles in children and adolescents is limited. Therefore, the aim of the present scoping review was to map out the current knowledge about SDB and LUTD in children and adolescents.

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Wood-degrading brown-rot fungi primarily target carbohydrates, leaving the lignin modified and potentially valuable for valorization. Here, we report a comprehensive comparison of how degrades hardwood and softwood, which have fundamentally different lignin structures. By harnessing the latest advancements in analytical methodologies, we show that removes more lignin from wood (up to 36%) than previously reported.

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Lactide, possessing two stereocenters and thus three distinct configurations (DD, DL, and LL), serves as a captivating building block for polymers and self-assembly. Notably, polylactide (PLA) exhibits stereocomplexation, displaying heightened interactions between different configurations compared with interactions within the same configuration. This characteristic renders PLA an intriguing subject for investigating self-assembly behavior.

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Manual vacuum aspiration (MVA) is a painful procedure often conducted without analgesia. The World Health Organization (WHO) recommends a paracervical block (PCB) as the mode of pain relief during MVA. Few studies have assessed patient perspectives on pain control during MVA.

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Objective: Chemicals used during canal disinfection and endodontic sealers have a deleterious effect on dentin bond strength. The aim of this study was to evaluate a novel clinical sequence to improve the resin-dentin microtensile bond strength (μTBS) to endodontically treated teeth.

Materials And Methods: Twenty human molars were distributed in four experimental groups (n = 5, N = 20): C-control group without exposure to any endodontic chemical substances (2.

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Effects of antihypertensives with and without IL-6 lowering properties on long-term blood pressure control: The prospective HELIUS cohort.

Int J Cardiol Cardiovasc Risk Prev

March 2025

Department of Public and Occupational Health, Amsterdam Public health Research Institute, Amsterdam university Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Article Synopsis
  • Chronic inflammation, particularly the role of interleukin-6 (IL-6), is being explored as a target for improving hypertension treatment.
  • In a study involving 1,510 participants over six years, it was found that calcium channel blockers (CCBs) with IL-6-lowering properties (specifically amlodipine and barnidipine) resulted in better blood pressure control compared to other CCBs.
  • No significant differences were seen in blood pressure control among other antihypertensive classes or across different ethnic groups, indicating a need for further research into IL-6's impact on hypertension management.
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Background: Community engagement is important for inclusive HIV cure development. This study evaluates current engagement in HIV cure research among affected communities in the Netherlands by analyzing awareness, interest, and information-seeking behavior. It also identifies participant characteristics and HIV-related illness perceptions linked to each engagement stage.

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Background: Due to malnutrition and tumor cachexia, body composition (BC) is frequently altered and known to adversely affect short- and long-term results in patients with cholangiocarcinoma (CCA). Here, we explored immune cell populations in the tumor and liver of CCA patients with respect to BC.

Methods: A cohort of 96 patients who underwent surgery for CCA was investigated by multiplexed immunofluorescence (MIF) techniques with computer-based analysis on whole-tissue slide scans to quantify and characterize immune cells in normal liver and tumor regions.

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Ball-milling of addition polymers such as polyolefins, polystyrene and polyacrylates can be used for depolymerization to obtain the respective monomers. However, absolute yields are typically low, especially from polyolefins which are notoriously difficult to depolymerize. To increase the viability of ball milling as a recycling technique, the effect of milling parameters on small hydrocarbon and monomer yields has to be understood.

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Article Synopsis
  • The Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) has been established at the National Institute of Chemistry in Ljubljana, marking Slovenia’s first center dedicated to precision medicine and cutting-edge therapies.
  • The CTGCT aims to advance cancer immunotherapy and personalized treatments for genetic diseases by developing innovative biomedical tools and collaborating with international institutions for effective therapy development.
  • Its focus on translating research into practice, alongside partnerships with clinicians and patient organizations, positions the CTGCT as a key player in improving access to gene and cell therapies across Slovenia and the broader Eastern European region.
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Limited data are available on VWF activity (VWF:Act) and factor VIII (FVIII:C) levels during delivery after VWF/FVIII concentrate administration in women with von Willebrand disease (VWD). We aimed to evaluate treatment with a specific VWF/FVIII concentrate on factor levels in women with VWD during delivery and the postpartum period. A retrospective single-center study was conducted between January 1, 2008, and August 1, 2022.

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Reduction behavior of PdO-NiO/SiO: how Pd location affects cinnamaldehyde hydrogenation.

Catal Sci Technol

December 2024

Laboratory of Inorganic Materials and Catalysis, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology Eindhoven The Netherlands

In this work, we study the reducibility of a PdO precursor placed by strong electrostatic adsorption on either NiO or SiO of NiO/SiO obtained by incipient wetness impregnation. The catalysts were characterized by HAADF-STEM, quasi- XPS, CO IR spectroscopy and H chemisorption as a function of the reduction temperature and evaluated for their performance in cinnamaldehyde hydrogenation. PdO on SiO requires reduction at higher temperatures to achieve appreciable rates of cinnamaldehyde hydrogenation.

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Purpose: Interest in prehabilitation, the preoperative enhancement of patients' condition, is rising in the surgical field. Challenging factors appear to be patients' motivation to participate in and their compliance with prehabilitation programs. The aim of this qualitative study was to study the real-life experience of prehabilitation by assessing the lived experience and perceptions of participants in a multimodal prehabilitation program and to explore factors that influence participation and compliance during prehabilitation.

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Background: There is a lack of information on the current healthcare systems for children with kidney diseases across Europe. The aim of this study was to explore the different national approaches to the organization and delivery of pediatric nephrology services within Europe.

Methods: In 2020, the European society for Paediatric Nephrology (ESPN) conducted a cross-sectional survey to identify the existing pediatric nephrology healthcare systems in 48 European countries covering a population of more than 200 million children.

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Background: Early life infections (ELIs), encompassing both viral and bacterial types, occur within the first six months of life. Influenced by genetic host factors and environmental conditions, the relationship between ELIs and subsequent allergic manifestations, particularly cow's milk protein allergy (CMPA) and atopic dermatitis (AD), is complex and not fully understood.

Objective: The aim of the current study was to examine the potential interplay between nutrition, infections, and allergic manifestations in the first six months of life in infants with a family history of allergies, who were either exclusively breastfed (EBF) or fed a combination of breast milk and standard (SF) or partially hydrolyzed infant formula (pHF).

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Simple quantitation and spatial characterization of label free cellular images.

Heliyon

December 2024

Human and Animal Physiology, Department Animal Sciences, Wageningen University, De Elst 1, 6708WD, Wageningen, the Netherlands.

Label-free imaging is routinely used during cell culture because of its minimal interference with intracellular biology and capability of observing cells over time. However, label-free image analysis is challenging due to the low contrast between foreground signals and background. So far various deep learning tools have been developed for label-free image analysis and their performance depends on the quality of training data.

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Objective: To compare various methods for extracting daily dosage information from prescription signatures (sigs) and identify the best performers.

Materials And Methods: In this study, 5 daily dosage extraction methods were identified. Parsigs, RxSig, Sig2db, a large language model (LLM), and a bidirectional long short-term memory (BiLSTM) model were selected.

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More inputs of antibiotics into groundwater but less into rivers as a result of manure management in China.

Environ Sci Ecotechnol

January 2025

Earth Systems and Global Change Group, Environmental Sciences Department, Wageningen University & Research, Droevendaalsesteeg 4, Wageningen, 6708 PB, the Netherlands.

Article Synopsis
  • Antibiotics are widely used in livestock, leading to environmental contamination of rivers and groundwater, yet there's insufficient data on their sources and distribution.
  • A new model, MARINA-Antibiotics (China-1.0), estimates antibiotic flows from livestock into China's rivers and groundwater, revealing that antibiotic inputs reduced in rivers but increased in groundwater from 2010 to 2020.
  • Key findings show fluoroquinolones are the main contributors to river pollution, while sulfonamides dominate groundwater pollution, indicating a need for improved strategies to address groundwater contamination due to livestock practices.
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Background: Intracerebral haemorrhage (ICH) accounts for approximately 28% of all strokes worldwide. ICH has a high case fatality, and only few survivors recover to independent living. Over the past decades, demographic changes, and changes in prevalence and management of risk factors may have influenced incidence.

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Background: The evidence on the link between cardiometabolic diseases (CMDs) and motor neuron diseases (MNDs) remains inconsistent. We aimed to determine whether there is an association of CMDs, namely, any cardiovascular disease, cardiac arrhythmia, heart failure, thromboembolic disease, hypertension, cerebrovascular disease, ischemic heart disease, diabetes mellitus type 2, and hypercholesterolemia with the risk and progression of MNDs.

Methods: We included 1463 MND patients (amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), progressive spinal muscular atrophy (PSMA), and unspecified MND) diagnosed from January 1, 2015, to July 1, 2023, in Sweden according to the Swedish Motor Neuron Disease Quality Registry (i.

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Behavior and emotion regulation of socially inhibited individuals in uncomfortable social situations: A mixed methods study.

Int J Clin Health Psychol

December 2024

Department of Medical and Clinical Psychology, CoRPS - Center of Research on Psychological disorders and Somatic diseases, Tilburg University, Netherlands.

Article Synopsis
  • The study examined how people regulate their emotions and behaviors in uncomfortable situations, focusing on traits like social inhibition.
  • Data was collected from 451 participants, and a latent profile analysis revealed seven distinct patterns of emotion regulation based on different situations.
  • Findings indicate that the context of the situation heavily influences emotion regulation strategies, with socially inhibited individuals often avoiding situations instead of using emotion regulation techniques.
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Although child loss impairs well-being, its impact on behavioral exchanges between bereaved parents remains understudied. We compared bereaved and non-bereaved couples regarding affectionate touch levels, the role of affectionate touch in intimacy, and the association between partners' affectionate touch similarity and intimacy. Bereaved (228 couples, 27 individuals) and non-bereaved (258 couples, seven individuals) people participated in our seven-day diary study.

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