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Cd44: a marker of squamous differentiation in adenosquamous neoplasms.

Arch Pathol Lab Med

February 2000

Department of Pathology, Division of Surgical Pathology, the Kaplan Cancer Center of the New York University Medical Center, New York, NY, USA.

Objective: To test the hypothesis that CD44 standard (CD44[s]) and its other variants, CD44v6 and CD44v7-8, might be useful markers of squamous differentiation in epithelial tumors.

Design: We studied expression of CD44(s), CD44v6, and CD44v7-8 using immunohistochemistry in human tumors that had squamous differentiation, glandular differentiation, or both arising in the colon, stomach, esophagus, lung, pancreas, gallbladder, or uterus/cervix, as well as in adjacent nonneoplastic tissues. Formalin-fixed, paraffin-embedded archival tissue specimens of 33 adenosquamous tumors were used.

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