The Beneficial Application of Turmeric (Curcuma longa L.) on Health and Egg Production, in Layers: A Review.

Background: Turmeric (Curcuma longa L.) is a widely recognized spice and medicinal plant that has gained significant attention for its potential health benefits. This review aims to provide a comprehensive overview of the beneficial applications of turmeric in improving health and egg production in layers.

Enhanced convolutional neural network architecture optimized by improved chameleon swarm algorithm for melanoma detection using dermatological images.

Early detection and treatment of skin cancer are important for patient recovery and survival. Dermoscopy images can help clinicians for timely identification of cancer, but manual diagnosis is time-consuming, costly, and prone to human error. To conduct this, an innovative deep learning-based approach has been proposed for automatic melanoma detection.

A facile and green procedure in preparing dibenzo-chromeno-phenazine-diones using an effectual and recyclable Brønsted acidic ionic liquid.

First, a Brønsted acid ionic liquid (BAIL) in the role of a double acid-base called 1,3-n-propyl-bipyridinium bisulfonic acid-ditrifluoroacetate (PBPBSDT) was produced, and its skeleton was determined via TGA, mass, C NMR, F NMR, H NMR and FT-IR data. Further, it was successfully applied in the preparation of dibenzo-chromeno-phenazine-dione derivatives (1a-12a, 9-15 min, 90-98%) via one-pot multicomponent domino reaction among 2 mmol 2-hydroxynaphthalene-1,4-dione, 1 mmol benzene-1,2-diamine, and 1 mmol aldehydes under optimal conditions (5 mol% of PBPBSDT, solvent-free, 60 °C). The proper reproducibility of the PBPBSDT homogeneous catalyst (5 times), solvent-free medium, reasonable TON (Turnover Number) and TOF (Turnover Frequency) numbers, the non-metallic framework of the catalyst, and the formation of C-N, C = N, C-C, C = C, C-O bonds in a single operation are the distinct advantages of this protocol.

Targeting the lung tumor microenvironment by phytochemicals and their nanoformulations.

Lung malignancies are among the most prevalent and foremost causes of tumor-related deaths. Despite significant advancements in the understanding and management of lung cancer, resistance to traditional treatments remains a significant challenge. Understanding and targeting tumor microenvironment (TME) have attracted interest in the recent decade for eliminating various solid tumors.

Crystalline engineering of FAPbI pyrrolidinium ionic liquid for stable perovskite solar cells with 21.72% efficiency.

Improving the crystallinity of formamidinium triiodide (FAPbI) perovskite layer is one of the most effective approaches to increase the photovoltaic performance and stability of FAPbI-based solar cells (FSCs). In the current study, FAPbI layers were fabricated through a sequential deposition method. The morphology and crystalline properties of the FAPbI layers were modified by controlling the lead iodide (PbI) precursor by adding pyrrolidinium (Pyr) material into the PbI layer and modulating the FAPbI crystallization.

In situ decorated pd NPs on Triazin-encapsulated FeO/SiO-NH as magnetic catalyst for the synthesis of diaryl ethers and oxidation of sulfides.

This article is devoted to the synthesis of a new magnetic palladium catalyst that has been immobilized on A-TT-Pd coated-magnetic FeO nanoparticles. Such surface functionalization of magnetic particles is a promising method to bridge the gap between heterogeneous and homogeneous catalysis approaches. The structure, morphology, and physicochemical properties of the particles were characterized through different analytical techniques, including TEM, FT-IR, XRD, SEM, EDS, TGA-DTG, ICP, and VSM techniques.

siRNA-based strategies to combat drug resistance in gastric cancer.

Chemotherapy is a key treatment option for gastric cancer, but over 50% of patients develop either inherent or acquired resistance to these drugs, resulting in a 5-year survival rate of only about 20%. The primary treatment for advanced gastric cancer typically involves chemotherapy based on platinum or fluorouracil. Several factors can contribute to platinum resistance, including decreased drug uptake, increased drug efflux or metabolism, enhanced DNA repair, activation of pro-survival pathways, and inhibition of pro-apoptotic pathways.

Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs.

Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora. A hyperactive inflammatory and immunological response in the gut has been shown to be one of the disease's long-term causes despite the complexity of the clinical pathology of IBD. The innate immune system activator known as human gut inflammasome is thought to be a significant underlying cause of pathology and is closely linked to the development of IBD.

The tryptophan catabolite or kynurenine pathway in long COVID disease: A systematic review and meta-analysis.

Background: Recent studies confirm the involvement of activated immune-inflammatory responses and increased oxidative and nitrosative stress in Long COVID (LC) disease. However, the influence of these pathways on the metabolism of tryptophan (TRP) through the TRP catabolite (TRYCAT) pathway and their mediating effects on LC pathophysiology, has not been fully explored.

Objective: This meta-analysis investigates peripheral TRP and TRYCAT levels and the TRYCAT pathway in patients with LC disease.

Correlation between lncRNAs with human molecular chaperons in cancer immunopathogenesis and drug resistance.

The development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves.

Melatonin mitigates doxorubicin induced chemo brain in a rat model in a NRF2/p53-SIRT1 dependent pathway.

Cancer is a critical health problem, and chemotherapy administration is mandatory for its eradication. However, chemotherapy like doxorubicin (Dox) has serious side-effects including cognitive impairment or chemo brain. Melatonin is a neuroprotective agent that has antioxidant, and anti-inflammatory effects.

Detection and isolation of brain tumors in cancer patients using neural network techniques in MRI images.

MRI imaging primarily focuses on the soft tissues of the human body, typically performed prior to a patient's transfer to the surgical suite for a medical procedure. However, utilizing MRI images for tumor diagnosis is a time-consuming process. To address these challenges, a new method for automatic brain tumor diagnosis was developed, employing a combination of image segmentation, feature extraction, and classification techniques to isolate the specific region of interest in an MRI image corresponding to a brain tumor.

Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential.

Since suppressor/enhancer of Lin-12-like (SEL1L) was cloned in 1997, various pieces of evidence from lower species suggest it plays a significant role in protein degradation via the ubiquitin-proteasome system. The relevance of SEL1L in many aspects of malignant transformation and tumorigenic events has been the subject of research, which has shown compelling in vitro and in vivo findings relating its altered expression to changes in tumor aggressiveness. The Endoplasmic Reticulum (ER) in tumor cells is crucial for preserving cellular proteostasis by inducing the unfolded protein response (UPR), a stress response.

An overview of lncRNA NEAT1 contribution in the pathogenesis of female cancers; from diagnosis to therapy resistance.

Despite the ongoing progress in detecting and treating cancer, there is still a need for extensive research into the molecular mechanisms involved in the emergence, progression, and resistance to recurrence of female reproductive tissue-specific cancers such as ovarian, breast, cervical, and endometrial cancers. The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) that exhibits increased expression in female tumors. Moreover, elevated levels of NEAT1 have been associated with poorer survival outcomes in cancer patients.

Role of the AMP-Activated Protein Kinase in the Pathogenesis of Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is a complex disorder characterized by elevated androgen levels, menstrual irregularities, and polycystic morphology of the ovaries. Affecting 6-10% of women in childbearing age, PCOS is a leading cause of infertility worldwide. In recent years, there has been a growing acknowledgment of the involvement of adenosine monophosphate-activated protein kinase (AMPK) in the development of polycystic ovary syndrome (PCOS).

Synthesis, characterization, and applications of starch-based nano drug delivery systems for breast cancer therapy: A review.

The review examined the potential of starch-based drug delivery systems for managing breast cancer efficiently. It covered the background of breast cancer and the significance of drug delivery systems in treatment enhancement. Starch, known for its versatile physicochemical properties, was explored as a promising biopolymer for drug delivery.

Optimizing electric load forecasting with support vector regression/LSTM optimized by flexible Gorilla troops algorithm and neural networks a case study.

This research work focuses on addressing the challenges of electric load forecasting through the combination of Support Vector Regression and Long Short-Term Memory (SVR/LSTM) methodology. The model has been modified by a flexible version of the Gorilla Troops optimization algorithm. The objective of this study is to enhance the precision and effectiveness of load forecasting models by integrating the adaptive functionalities of the Gorilla Troops algorithm within the SVR/LSTM framework.

MicroRNA-enriched exosome as dazzling dancer between cancer and immune cells.

Exosomes are widely recognized for their roles in numerous biological processes and as intercellular communication mediators. Human cancerous and normal cells can both produce massive amounts of exosomes. They are extensively dispersed in tumor-modeling animals' pleural effusions, ascites, and plasma from people with cancer.