6 results match your criteria: "the Institute of Drug Discovery and Development[Affiliation]"
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors.
Protein Cell
January 2023
The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Article Synopsis
- The COVID-19 pandemic has infected over 109 million individuals and resulted in over 2 million deaths, with no effective treatments currently available.
- Researchers screened around 1.8 million small molecules targeting the main and papain-like proteases of the SARS-CoV-2 virus, identifying 1851 inhibitors for the main protease and 205 for the papain-like protease.
- Eight small molecules demonstrated dual inhibition of both proteases and showed promise as potential COVID-19 treatments, with some exhibiting over 40% antiviral potency and low toxicity, along with detailed structural data for further research.
Ligand recognition and activation of neuromedin U receptor 2.
Nat Commun
December 2022
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
Neuromedin U receptor 2 (NMU2), an emerging attractive target for treating obesity, has shown the capability in reducing food intake and regulating energy metabolism when activated. However, drug development of NMU2 was deferred partially due to the lack of structural information. Here, we present the cryo-electron microscopy (cryo-EM) structure of NMU2 bound to the endogenous agonist NmU-25 and G at 3.
View Article and Find Full Text PDFKupffer cells play a crucial role in monocrotaline-induced liver injury by producing TNF-α.
Toxicology
February 2022
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; Zhongshan Branch, the Institute of Drug Discovery and Development, Chinese Academy of Sciences, China. Electronic address:
Monocrotaline (MCT), an unsaturated pyrrolizidine alkaloid (PA) in plants, is mainly toxic to the lung and liver of mammals. As a commonly used tool for liver injury model, the mechanism of MCT hepatoxicity has still not been fully clarified. Kupffer cells (KCs) are the liver-resident macrophages and have various responses to different toxicants and liver damage.
View Article and Find Full Text PDFStructural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun
July 2021
CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation. However, molecular details that govern its endogenous chemokine recognition and receptor activation remain elusive. Here we report three cryo-electron microscopy structures of G protein-coupled CCR5 in a ligand-free state and in complex with the chemokine MIP-1α or RANTES, as well as the crystal structure of MIP-1α-bound CCR5.
View Article and Find Full Text PDFPrevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.
Cell Death Dis
May 2021
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Acute liver injury (ALI) has multiple causes and results in liver dysfunction. Severe or persistent liver injury eventually leads to liver failure and even death. Pregnane X receptor (PXR)-null mice present more severe liver damage and lower rates of autophagy.
View Article and Find Full Text PDFAllosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020).
Curr Med Chem
June 2021
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin 300070, China.
Srchomology-2-domain-containing PTP 2 (SHP2) is a nonreceptor phosphatase encoded by the PTPN11 gene. Over expression of SHP2 is associated with various human diseases, such as Noonan syndrome, LEOPARD syndrome, and cancers. To overcome the shortcomings of existing orthosteric inhibitors, novel inhibitors targeting the allosteric site of SHP2 with high selectivity and low toxicity are under development.
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