1,391 results match your criteria: "the Icahn School of Medicine at Mount Sinai[Affiliation]"

Objectives: Fortunately, operating room deaths and unexpected deaths are infrequent occurrences. However, when they occur, the surgeon is called upon to deliver this news to family and loved ones. There is a paucity of literature on this topic and little guidance preparing cardiothoracic surgeons for this important but difficult situation.

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The Clinical Practice Standards Committee of the American Association for Thoracic Surgery assembled an expert panel and conducted a systematic review of the literature detailing studies directly comparing treatment options for high-risk patients with stage I non-small cell lung cancer (NSCLC). A systematic search was performed to identify publications comparing outcomes following image-guided thermal ablation (IGTA), stereotactic ablative radiotherapy (SABR), and sublobar resection-the main treatment options applicable to high-risk patients with stage I NSCLC. There were no publications detailing completed randomized controlled trials comparing these treatment options.

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Systematic Review of Stereotactic Ablative Radiotherapy (SABR)/ Stereotactic Body Radiation Therapy (SBRT) for Treatment of High-Risk Patients with Stage I Non-Small Cell Lung Cancer.

Semin Thorac Cardiovasc Surg

December 2024

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, and UPMC Hillman Cancer Center. Pittsburgh, PA. Electronic address:

Stereotactic ablative radiotherapy (SABR) has emerged as an alternative, non-surgical treatment for high-risk patients with stage I non-small cell lung cancer (NSCLC) with increased use over time. The American Association for Thoracic Surgery (AATS) Clinical Practice Standards Committee (CPSC) assembled an expert panel and conducted a systematic review of the literature evaluating the results of SABR, which is also referred to as stereotactic body radiation therapy (SBRT) or stereotactic radiosurgery (SRS), prior to developing treatment recommendations for high-risk patients with stage I NSCLC based on expert consensus. Publications detailing the findings of 16 prospective studies of SABR and 14 retrospective studies of SABR for the management of early-stage lung cancer in 54 697 patients were identified by systematic review of the literature with further review by members of our expert panel.

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Systematic Review of Sublobar Resection for Treatment of High-Risk Patients with Stage I Non-Small Cell Lung Cancer.

Semin Thorac Cardiovasc Surg

December 2024

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, and UPMC Hillman Cancer Center. Pittsburgh, PA. Electronic address:

Sublobar resection offers a parenchymal-sparing surgical alternative to lobectomy and includes wedge resection and segmentectomy. Sublobar resection has been historically utilized in high-risk patients with compromised lung function; however, the technique is becoming more prevalent for normal-risk patients with peripheral lung tumors < 2 cm. In this article, we summarize the technique of sublobar resection, the importance of surgical margins and lymph node sampling, patient selection, perioperative complications, outcomes, and the impact of sublobar resection on the quality of life.

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Article Synopsis
  • * An expert panel from the American Association for Thoracic Surgery reviewed existing literature and reached a consensus on treatment modalities, which include sublobar resection, image-guided thermal ablation (IGTA), and stereotactic ablative radiotherapy (SABR).
  • * The conclusions highlight that surgical approaches are often preferred when safe, but SABR and IGTA can be suitable alternatives; multidisciplinary evaluations and patient preferences play crucial roles in treatment decisions.
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Objective: A significant proportion of patients with stage I non-small cell lung cancer (NSCLC) are considered at high risk for complications or mortality after lobectomy. The American Association for Thoracic Surgery (AATS) previously published an expert consensus document detailing important considerations in determining who is at high risk. The current objective was to evaluate treatment options and important factors to consider during treatment selection for these high-risk patients.

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Systematic Review of Image-guided Thermal Ablation for Treatment of High-Risk Patients with Stage I Non-Small Cell Lung Cancer.

Semin Thorac Cardiovasc Surg

December 2024

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, and UPMC Hillman Cancer Center. Pittsburgh, PA. Electronic address:

Image-guided thermal ablation (IGTA) applied to pulmonary pathology is an alternative to surgery in high-risk patients with stage I non-small cell lung cancer (NSCLC). Its application to lung neoplasm was first introduced in 2001 and has been implemented to treat metastatic disease to the lung or in select medically inoperable patients with peripheral stage I NSCLC. IGTA may also be an alternative to treat stage I NSCLC in non-operable patients with interstitial lung disease in whom a radiation modality is deemed too high risk.

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Objective: The American Association for Thoracic Surgery (AATS) Clinical Practice Standards Committee (CPSC) previously published important considerations in determining who is at high risk for complications or mortality after lobectomy. Sublobar resection, stereotactic ablative radiotherapy, or image-guided thermal ablation is typically considered when the risks associated with lobectomy are high. The current objective was to evaluate important lung-nodule-related factors to consider during treatment selection for high-risk patients with stage I non-small cell lung cancer (NSCLC).

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Article Synopsis
  • The study investigates the link between maternal lifetime stress and child asthma, exploring how factors like maternal pre-pregnancy body mass index and race/ethnicity might affect this relationship.
  • Higher maternal stress was found to significantly increase the likelihood of child asthma, particularly among mothers categorized as obese.
  • The results suggest that understanding the interplay of various factors is crucial in addressing how maternal stress impacts children's health, especially regarding asthma in early childhood.
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Diabetes results from an inadequate number of insulin-producing human beta cells. There is currently no clinically available effective means to restore beta cell mass in millions of people with diabetes. Although the DYRK1A inhibitors, either alone or in combination with GLP-1 receptor agonists (GLP-1) or transforming growth factor β (TGF-β) superfamily inhibitors (LY), induce beta cell replication and increase beta cell mass, the precise mechanisms of action remain elusive.

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  • - Individuals with spinal cord injury (SCI) above T6 often experience issues with blood pressure regulation, leading to persistent low blood pressure.
  • - A study tested the effects of daily midodrine (10 mg) versus placebo over 30 days on blood pressure, cerebral blood flow velocity (CBFv), and cognitive performance in hypotensive SCI patients.
  • - Results showed that midodrine significantly increased systolic blood pressure and diastolic CBFv compared to placebo, but did not significantly affect cognitive performance, indicating a need for further research on effective treatments.
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Introduction: Psoriasis in high-impact areas, including the scalp, nails, palms, and soles, can disproportionately impair patient quality of life. Here, we evaluate the 2-year efficacy of bimekizumab treatment in patients with moderate to severe plaque psoriasis in post hoc analyses of five phase 3/3b trials.

Methods: High-impact area efficacy data were pooled through 2 years across five phase 3/3b trials: BE VIVID, BE READY, BE SURE, their ongoing open-label extension (OLE) BE BRIGHT, and BE RADIANT (including its double-blinded treatment period and the first year of its OLE).

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Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms.

Immunity

December 2024

Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Article Synopsis
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Love Thy Neighbor? Exploring Gastroenterology Attitudes Toward Endometriosis Screening.

Dig Dis Sci

November 2024

Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Endometriosis is a chronic painful condition affecting 10% of reproductive-aged women with a high prevalence of overlapping gastrointestinal symptoms. There is a significant diagnostic delay for endometriosis and current screening practices for endometriosis in gastroenterology clinic populations have not been evaluated. 112 gastroenterology providers (57.

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Objective: Identifying persons with HIV (PWH) at increased risk for Alzheimer's disease (AD) is complicated because memory deficits are common in HIV-associated neurocognitive disorders (HAND) and a defining feature of amnestic mild cognitive impairment (aMCI; a precursor to AD). Recognition memory deficits may be useful in differentiating these etiologies. Therefore, neuroimaging correlates of different memory deficits (i.

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Background: We aimed to explore physician perspectives on communication quality across pediatric contexts.

Methods: We conducted semi-structured interviews over a 4-month period. Purposive sampling was conducted to ensure a broad sampling of pediatricians from multiple subspecialties and practice settings.

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Article Synopsis
  • Inflammatory bowel disease (IBD) poses a significant health risk, including an increased chance of developing colorectal cancer (CRC), but understanding and treatment options are still limited.
  • This study identifies FBXO22, a protein that helps regulate cellular processes, as a key player in inhibiting inflammation and CRC by promoting the degradation of a specific form of mTOR, which is involved in cancer signaling.
  • Treatment with the mTOR inhibitor rapamycin shows promise in reducing colorectal inflammation and cancer effects, highlighting the potential role of FBXO22 and mTOR pathways in colorectal disease management.
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Could "preclinical takotsubo syndrome" be the cause of spontaneous coronary artery dissection?

Curr Probl Cardiol

January 2025

From the Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY, USA. Electronic address:

Article Synopsis
  • Takotsubo syndrome (TTS) and spontaneous coronary artery dissection (SCAD) are increasingly recognized as interconnected conditions, with SCAD potentially triggering TTS in response to various stresses.
  • The debate continues regarding the underlying mechanisms of both conditions, but SCAD can act as a precursor to TTS due to the stresses it imposes on the heart.
  • The review suggests examining the relationship between TTS and SCAD further, recommending strategies that consider both conditions regardless of which one occurs first.
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Rabex-5 (also called RabGEF1), a protein originally characterized for its Rab5 GEF function, also has an A20-like E3 ubiquitin ligase domain. We and others reported that Rabex-5 E3 activity promotes Ras mono- and di-ubiquitination to inhibit Ras signaling in Drosophila and mammals. Subsequently, we reported that Rabex-5 inhibits Notch signaling in the Drosophila hematopoietic system.

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Objective: We sought to correlate the time lag between psoriatic arthritis (PsA) symptom onset and diagnosis to the likelihood and severity of depression, social impairment, and disease impact on quality of life.

Methods: This cross-sectional study conducted by the National Psoriasis Foundation (NPF) surveyed individuals with PsA using patient-reported outcome measures.

Results: The analysis cohort comprised 2,196 patients with PsA.

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Objective: Dermatologic office procedures involving needles including injection of local anesthetic both cutaneously and intraorally, botulinum toxin, fillers and keloids, as well as venipuncture and a plethora of other procedures can often cause pain that ranges from mild to severe. The technique of utilizing vibration frequently lessens pain. Vibration anesthesia is a non-invasive, inexpensive, virtually side-effect free, and well-established method of lessening pain during dermatologic procedures.

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Background: Mass shootings represent a persistent public health crisis. Prior studies have linked social determinants of health (SDOH) to the phenomenon of gun violence, but there remain limited analyses on mass shooting events specifically.

Methods: Mass shooting events from 2014-2019 were recorded from the Gun Violence Archive.

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Tracheal transplantation: lessons learned that may apply to lung transplantation.

Curr Opin Organ Transplant

December 2024

Institute for Airway Sciences, Co-Scientific Director, Center for Epithelial and Airway Biology and Regeneration, Basic Science Research, Otolaryngology, Director, Developmental Origins of Health and Disease, Department of Otolaryngology, Department of Cell, Developmental and Regenerative Biology, Department of Pathology, Molecular and Cell Based Medicine, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Purpose Of Review: The purpose of this review is to explore the lessons learned from experimental and human tracheal transplantation to determine if this information may be applied to lung transplantation.

Recent Findings: Experimental work in animal models and the recent human tracheal transplantation suggests that a robust tracheal vascular supply prevents anastomotic complications. Further, this work demonstrates that tracheal allografts undergo a progressive chimerism as recipient epithelium repopulates the allograft.

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