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DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma.
Pathol Res Pract
April 2015
Institute of Oncology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 639, Zhi Zao Ju Rd, Shanghai 200011, China; Department of Pathology, the First People's Hospital of ChangzhouV (the Third Affiliated Hospital of Soochow University), Changzhou 213003, China. Electronic address:
The distinction between chromophobe renal cell carcinoma (ChRCC), clear cell renal cell carcinoma (CRCC) and renal oncocytoma may cause a diagnostic dilemma. The usefulness of DOG1, cyclin D1, CK7, CD117 and vimentin in the differential diagnosis of these renal epithelial tumors was investigated. DOG1 was positive in ChRCC (32 of 32, 100%) and in renal oncocytoma (21 of 21, 100%).
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