544 results match your criteria: "the First Hospital of Hunan University of Chinese Medicine[Affiliation]"
The role of Th/Treg immune cells in osteoarthritis.
Front Immunol
October 2024
Department of Joint Orthopedics, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Article Synopsis
- * It is caused by inflammation in different parts of the joint and is influenced by special immune cells called T cells.
- * New research looks at how these T cells and their different types affect OA and suggests new ways to treat it in the future.
Nanodelivery system of traditional Chinese medicine bioactive compounds: Application in the treatment of prostate cancer.
Phytomedicine
December 2024
The First Hospital of Hunan University of Chinese Medicine, 95, Changsha 410007, Hunan, China. Electronic address:
Article Synopsis
- Traditional Chinese medicine (TCM) has a long-standing history of effectively treating prostate cancer, with bioactive compounds like curcumin and quercetin showing potential against the disease.
- Recent studies suggest that using nano-delivery systems enhances these compounds' bioavailability and targeting ability, improving their anti-cancer effects.
- The review discusses the mechanisms and clinical prospects of TCM compounds in nano-delivery systems, emphasizing the need for more clinical trials to ensure their effectiveness and safety in cancer treatment.
Development and Validation of a Diagnostic Model for Enhancing Lesions on Breast MRI: Based on Kaiser Score.
Acad Radiol
September 2024
Department of Radiology, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha 410016, China (X.Y., Y.C.). Electronic address:
Article Synopsis
- This study aims to create and validate a new diagnostic model using the Kaiser score for predicting the likelihood of malignancy in breast lesions detected by MRI.
- Data was collected from two hospitals, analyzing information from 391 patients who had preoperative MRI scans showing enhancing lesions, which were later confirmed as benign or malignant.
- The researchers used statistical methods like LASSO regression and multivariate logistic regression to develop the model, comparing its effectiveness against the Kaiser score alone and assessing its clinical usability.
PF-PEG@ASIV-EXO Hydrogel Accelerates Diabetic Wound Healing by Ferroptosis Resistance and Promoting Angiogenesis.
ACS Biomater Sci Eng
October 2024
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China.
Article Synopsis
- Astragaloside IV (ASIV) enhances the growth of endothelial progenitor cells (EPCs), which are crucial for wound healing, while a new composite delivery system (PF-PEG@ASIV-EXO) utilizes exosomes and hydrogels to target these cells effectively.
- The study evaluated the biocompatibility of the PF-PEG@ASIV-EXO system and its effects on EPC function, including cell viability, blood vessel formation (angiogenesis), and cellular health in high-glucose environments resembling diabetes.
- Results from diabetic rat wounds showed that PF-PEG@ASIV-EXO not only increased the healing process but also elevated important markers for blood vessels and reduced harmful cell death,
[Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4].
Zhongguo Zhong Yao Za Zhi
September 2024
Hunan Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Depressive Diseases Changsha 410208, China Science & Technology Innovation Center, Hunan University of Chinese Medicine Changsha 410208, China.
Article Synopsis
- * Researchers induced a diabetes-related depression model in rats through diet, injections, and stress, then assessed behaviors, blood glucose, immune markers, and synaptic structures using various tests and analyses.
- * Findings showed that the model rats exhibited increased immobility and reduced activity, alongside specific changes in immune and neurotransmitter levels in the hippocampus, indicating the potential effectiveness of the formula in modulating these negative effects.
Effect of post-traumatic stress disorder on type 2 diabetes and the mediated effect of obesity: a Mendelian randomization study.
Front Endocrinol (Lausanne)
September 2024
Department of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Objective: Whether the role of post-traumatic stress disorder (PTSD) on type 2 diabetes (T2D) is mediated by obesity or other mediating factors is controversial. This study was designed to assess the impact of PTSD on genetic susceptibility to T2D and mediating factors.
Methods: The datasets for PTSD, T2D, obesity, hypertension, hyperlipidemia, smoking status, and alcohol consumption were obtained from genome-wide association studies.
Auricular pressure as an adjuvant treatment for type 2 diabetes: data mining and meta-analysis.
Front Endocrinol (Lausanne)
September 2024
School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Article Synopsis
- - This study investigated the effectiveness of auricular pressure therapy combined with conventional treatments for managing type 2 diabetes, analyzing data from various databases until November 2023.
- - The results showed that patients receiving combined treatment had significantly lower levels of fasting blood glucose, postprandial blood glucose, HbA1c, cholesterol, and blood pressure compared to those only on conventional treatment, with no significant increase in adverse events.
- - Key acupoints identified for auricular pressure therapy included AH, TF, AT, CO, and CO, suggesting that this approach could be a valuable addition to diabetes care.
Development and Comparative Study of a Mouse Model of Airway Inflammation and Remodeling Induced by Exosomes Derived from Bone Marrow Mesenchymal Stem Cells.
Bull Exp Biol Med
August 2024
The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province, China.
We developed a model of inflammation and airway remodeling in C57 mice provoked by exosomes derived from bone marrow mesenchymal stem cells infected by respiratory syncytial virus (RSV). The mean size of control and infected exosomes in vitro were 167.9 and 118.
View Article and Find Full Text PDFExploring the therapeutic potential of interleukin-6 receptor blockade in cardiovascular disease treatment through Mendelian randomization.
Sci Rep
September 2024
The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan, China.
Article Synopsis
- Interleukin-6 (IL-6) is linked to cardiovascular diseases (CVD), and blocking its receptor (IL-6R) shows potential as a treatment option, though its effects on different CVD types are unclear.
- This study used a Mendelian randomization approach to evaluate the impact of IL-6R blockade on conditions like hypertension (HTN), coronary heart disease (CHD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF).
- Results indicated that IL-6R blockade significantly reduced the risk of CHD and MI but showed no significant impact on HTN, AF, or HF, suggesting its treatment efficacy could vary among different CVD types.
Background: Fertility rates are declining globally, and male infertility is increasingly recognized as a significant challenge. This study aims to present the latest findings on the effectiveness and safety of combining traditional Chinese medicine (TCM) with L-carnitine (LC) for treating male infertility.
Methods: We searched 8 databases.
Ginsenoside Rg1 treats chronic heart failure by downregulating ERK1/2 protein phosphorylation.
In Vitro Cell Dev Biol Anim
October 2024
Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China.
In this study, we investigated the potential therapeutic mechanism of ginsenoside Rg1 (GRg1) in chronic heart failure (CHF), focusing on its regulation of ERK1/2 protein phosphorylation. H9c2 cardiomyocytes and SD rats were divided into the control group, CHF (ADR) group, and CHF+ginsenoside Rg1 group using an isolated cardiomyocyte model and an in vivo CHF rat model induced by adriamycin (ADR). Cell viability, proliferation, apoptosis, and the expression of relevant proteins were measured to assess the effects of GRg1.
View Article and Find Full Text PDFClinical features, treatment, and outcome of nivolumab-induced cholangitis.
Immunopharmacol Immunotoxicol
December 2024
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Article Synopsis
- Cholangitis, a rare and severe reaction to the cancer drug nivolumab, has unclear symptoms; this study aimed to examine its clinical features, imaging results, and treatment options.
- The analysis included 38 patients, revealing that symptoms like abdominal pain and fever often appeared after an average of seven treatment cycles, with significant liver enzyme elevations noted in some cases.
- The study suggests clinicians should closely monitor for cholangitis in patients on nivolumab, use appropriate imaging techniques, and consider combining steroids with ursodeoxycholic acid (UDCA) for better treatment outcomes.
Workplace violence and turnover intention among Chinese nurses: the mediating role of compassion fatigue and the moderating role of psychological resilience.
BMC Public Health
September 2024
Hunan Traditional Chinese Medical College, ZhuZhou, Hunan, China.
Background: Workplace violence is a global public health issue and a major occupational hazard cross borders and environments. Nurses are the primary victims of workplace violence due to their frontline roles and continuous interactions.
Objective: The present study aimed to investigate the status of workplace violence, turnover intention, compassion fatigue, and psychological resilience among Chinese nurses, and explore the mediating role of compassion fatigue and the moderating role of psychological resilience on relationship between workplace violence and turnover intention among Chinese nurses.
Clinical characteristics of double negative atypical inflammatory demyelinating disease: A prospective study.
Ann Clin Transl Neurol
October 2024
Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410000, Hunan, P.R. China.
Objective: This study aimed to investigate the clinical characteristics and predictors of relapse in double negative atypical inflammatory demyelinating disease (IDD) and to explore potential antigenic targets by tissue-based assays (TBA) using rat brain indirect immunofluorescence.
Methods: We compared the clinical, laboratory, and MRI data of double negative atypical IDD with other IDD patients. Serum samples were collected for TBA.
Unloading and successful treatment with bioresorbable stents during percutaneous coronary intervention: A case report.
World J Cardiol
August 2024
Department of Cardiology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
Background: With the development of percutaneous coronary intervention (PCI), the number of interventional procedures without implantation, such as bioresorbable stents (BRS) and drug-coated balloons, has increased annually. Metal drug-eluting stent unloading is one of the most common clinical complications. Comparatively, BRS detachment is more concealed and harmful, but has yet to be reported in clinical research.
View Article and Find Full Text PDFMale infertility risk and plasma lipidome: a Mendelian randomization study.
Front Endocrinol (Lausanne)
August 2024
Andrology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Article Synopsis
- Recent studies show a worldwide decline in sperm quality, linking it closely with male infertility and indicating that the plasma lipidome may play an important role in this issue.
- This research utilized a Mendelian randomization analysis of data from 179 studies, identifying 13 plasma lipid types linked to male infertility, with 9 being protective and 4 considered risk factors.
- The findings highlight the need for further clinical trials to validate these lipidome types as potential biomarkers for male infertility.
An Exploratory Study on the Rapid Detection of Volatile Organic Compounds in Gardenia Fruit Using the Heracles NEO Ultra-Fast Gas Phase Electronic Nose.
Metabolites
August 2024
State Key Laboratory of Chinese Medicine Powder and Medicine Innovation in Hunan (Incubation), Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha 410208, China.
Article Synopsis
- Gardenia fruit is valued for its functional food properties and natural pigments, but many products share the same name, complicating identification.
- A study utilized the Heracles NEO electronic nose to analyze VOCs in six different batches of gardenia fruit, revealing distinct odor profiles that aid in their rapid identification.
- The analysis, which employed PCA and DFA, identified hexanal as a key differentiator among samples and grouped the fruits into two categories, offering insights for future quality control and identification methods.
Establish TIIC signature score based the machine learning fusion in bladder cancer.
Discov Oncol
August 2024
Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Article Synopsis
- * Researchers analyzed RNA-seq data and clinical information using machine learning to identify RNA features associated with tumor-infiltrating immune cells (TIICs), ultimately developing a TIIC signature score to assess its relationship with overall survival and therapy response.
- * The study found that the TIIC signature score was linked to patient survival and was predictive of immunotherapy success, with lower scores indicating better outcomes, highlighting its potential in improving treatment strategies for bladder cancer patients.
Clinical Features, Treatment, and Outcomes of Nivolumab-Induced Hemophagocytic Lymphohistiocytosis.
J Immunother
August 2024
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Haemophagocytic lymphohistiocytosis (HLH) is a rare and fatal immune-related event of nivolumab. The clinical features of nivolumab-induced HLH are unclear. The aim of this study was to investigate the clinical features, treatment, and outcome of nivolumab-induced HLH to provide information for prevention and treatment.
View Article and Find Full Text PDFAstrocyte-derived exosomal miR-378a-5p mitigates cerebral ischemic neuroinflammation by modulating NLRP3-mediated pyroptosis.
Front Immunol
August 2024
Medical School, Hunan University of Chinese Medicine, Changsha, China.
Objective: This study aimed to investigate the regulatory role of astrocyte-derived exosomes and their microRNAs (miRNAs) in modulating neuronal pyroptosis during cerebral ischemia.
Methods: Astrocyte-derived exosomes were studied for treating cerebral ischemia in both and models. The effects of astrocyte-derived exosomes on neuroinflammation were investigated by analyzing exosome uptake, nerve damage, and pyroptosis protein expression.
Clinical features, treatment, and prognosis of SGLT2 inhibitors induced acute pancreatitis.
Expert Opin Drug Saf
September 2024
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Article Synopsis
- - Recent studies suggest that sodium-glucose cotransporter-2 inhibitors (SGLT-2i) may be linked to acute pancreatitis (AP), but details on the clinical characteristics of this association were not well-defined.
- - This research reviewed case reports and clinical studies up to December 2023, including 21 patients with a median age of 50.5, finding common symptoms like abdominal pain and notable lab results indicating elevated lipase and amylase levels.
- - The study concluded that SGLT-2i can cause AP, highlighting the need for doctors to consider these medications as a potential cause of pancreatitis when diagnosing patients.
The emerging role of neutrophil extracellular traps in ulcerative colitis.
Front Immunol
August 2024
Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Ulcerative colitis (UC) is characterized by chronic non-recessive inflammation of the intestinal mucosa involving both innate and adaptive immune responses. Currently, new targeted therapies are urgently needed for UC, and neutrophil extracellular traps (NETs) are new therapeutic options. NETs are DNA-based networks released from neutrophils into the extracellular space after stimulation, in which a variety of granule proteins, proteolytic enzymes, antibacterial peptides, histones, and other network structures are embedded.
View Article and Find Full Text PDFMicrowave ablation for lymph node metastasis in thyroid cancer: the impact of lymph node diameter.
Front Endocrinol (Lausanne)
August 2024
Department of Ultrasound, The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Objectives: To explore the impact of lymph node diameter on the efficacy and safety of ultrasound-guided microwave ablation (MWA) in the treatment of cervical metastatic lymph nodes (CMLNs) from thyroid cancer.
Methods: A total of 32 patients with 58 CMLNs from thyroid cancer underwent ultrasound-guided MWA and were included in the retrospective study. Patients were divided into three groups based on the mean largest diameter of the CMLNs: Group A (diameter ≤10mm), Group B (10mm < diameter ≤20mm), and Group C (diameter >20mm).
Risk cycling in diabetes and autism spectrum disorder: a bidirectional Mendelian randomization study.
Front Endocrinol (Lausanne)
August 2024
The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Objective: The relationship between diabetes mellitus (DM) and autism spectrum disorder (ASD) remains controversial. This study aimed to analyze the causal relationship between different types of DM and ASD by bidirectional Mendelian randomization (MR).
Methods: Single nucleotide polymorphisms for type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM), and ASD were obtained from genome-wide association studies.
inhibits M2 tumor-associated macrophage polarization Wnt/β-catenin pathway modulation to suppress liver cancer.
World J Gastroenterol
August 2024
College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China.
Background: (CB), used in traditional Chinese medicine, exhibits anti-tumor effects in various cancer models. It also constitutes an integral component of a compound formulation known as Pien Tze Huang, which is indicated for the treatment of liver cancer. However, its impact on the liver cancer tumor microenvironment, particularly on tumor-associated macrophages (TAMs), is not well understood.
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