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[Biological role and related mechanism of autophagy in acute lung injury of hemorrhagic shock mice].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue

August 2024

Department of Emergency, the First Affiliated of Hebei North University, Zhangjiakou 075000, Hebei, China. Corresponding author: Wang Jia, Email:

Objective: To study the biological role and related mechanism of autophagy in acute lung injury (ALI) of hemorrhagic shock mice.

Methods: According to random number table method, wild-type male C57BL/6 mice were divided into control group, ALI group, rapamycin group and 3-methyladenine (3-MA) group, with 8 mice in each group. Light chain 3 (LC3) gene knockout mice with C57BL/6 background were divided into LC3 knockout group and LC3 knockout+ALI group, with 8 mice in each group.

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