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99 results match your criteria: "the First Affiliated Hospital of Shanxi Medical University[Affiliation]"
J Cell Mol Med
December 2024
Department of Digestive System Oncology, Shanxi Bethune Hospital, Shanxi Academy of Medical sciences, TongilShanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Krüppel-like factor 7 is a transcriptional activator and acts as an oncogene in human cancers, including hepatocellular carcinoma (HCC). Tryptophan metabolism is important for HCC cell proliferation, metastasis, and invasion. It is unclear whether KLF7 could regulate Trp metabolism in HCC.
View Article and Find Full Text PDFLife Sci
December 2024
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:
Aims: The impact of e-cigarettes/vaping on cardiac function remains contradictory owing to insufficient direct evidence of interorgan communication. Extracellular vesicles (EVs) have protective or detrimental effects depending on pathological conditions, making it crucial to understand their role in lung-cardiac cell interactions mediated by vaping inhalation.
Methods And Key Findings: Pulmonary EVs were characterized from animals that underwent 12 weeks of nicotine inhalation (vaping component) (EVs) or vehicle control (EVs).
J Immunother Cancer
October 2024
Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China
World J Surg Oncol
October 2024
Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Shanxi Hospital Cancer Hospital of Chinese Academy of Medical Sciences, Taiyuan, 031000, Shanxi Province, China.
Background: The purpose of this systematic review and meta-analysis is to assess the efficacy of various machine learning (ML) techniques in predicting preoperative lymph node metastasis (LNM) in patients diagnosed with papillary thyroid carcinoma (PTC). Although prior studies have investigated the potential of ML in this context, the current evidence is not sufficiently strong. Hence, we undertook a thorough analysis to ascertain the predictive accuracy of different ML models and their practical relevance in predicting preoperative LNM in PTC patients.
View Article and Find Full Text PDFNPJ Digit Med
October 2024
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing, China.
Identify the hypoxia genes related to chemotherapy resistance of oral cancer, and construct a chemotherapy response model by machine learning algorithm. 72 oral cancer patients with complete chemotherapy records and chemotherapy reactions were screened from the Cancer Genome Atlas (TCGA) database. According to the chemotherapy reactions, they were divided into chemotherapy sensitive group and chemotherapy resistant group.
View Article and Find Full Text PDFAutoimmunity
December 2024
School of Stomatology, Shanxi Medical University, Taiyuan, Taiyuan, China.
Background: Chronic periodontitis (CP) and allergic rhinitis (AR) have attracted wide attention as global public health problems with high incidence. Recent studies have shown that circulating interleukin-27 (IL-27) is associated with the risk of CP and AR. The aim of this study is to analyze the causal effect between them using Mendelian randomization (MR).
View Article and Find Full Text PDFSci Rep
April 2024
Department of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical University, Xi'an, 710032, China.
Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits potential tumorigenic roles in a variety of malignancies. However, there is no systematic and comprehensive pan-cancer analysis to investigate the diagnosis, prognosis, immune infiltration, and other related functions of CCDC58.
View Article and Find Full Text PDFNurse Educ Pract
March 2024
Department of Nursing, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi 030024, China.
Aim: The aim of this study was to evaluate the efficacy of evidence-based nursing (EBN) in patients with confirmed stroke.
Background: After acute hospital treatment, stroke patients often return home for rehabilitation. Stroke ward nursing, demonstrates improved disability-free survival rates.
Biol Direct
February 2024
Shanxi Medical University, 030001, Taiyuan, Shanxi, China.
Background: Lenvatinib is an oral small molecule inhibitor approved for treating patients with unresectable hepatocellular carcinoma (HCC) worldwide. Increasing cell sensitivity to lenvatinib would be an effective method of improving therapeutic efficacy.
Methods: High throughput methods was used to scan the differentially expressed genes (DEGs) related to lenvatinib sensitivity in HCC cells.
Funct Integr Genomics
January 2024
Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Taiyuan, China.
Members of the E26 transformation-specific (ETS) variant transcription factor family act as either tumor suppressors or oncogenic factors in numerous types of cancer. ETS variant transcription factor 7 (ETV7) participates in the development of malignant tumors, whereas its involvement in colorectal cancer (CRC) is less clear. In this study, The Cancer Genome Atlas (TCGA) and immunochemistry staining were applied to check the clinical relevance of ETV7 and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in CRC patients.
View Article and Find Full Text PDFJ Integr Med
November 2023
Department of Pharmacy, the Fifth Affiliated Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan 030012, Shanxi Province, China. Electronic address:
Objective: The aim of this study is to identify molecules from traditional Chinese medicine (TCM) with potential activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants.
Methods: We applied the Apriori algorithm to identify important combinations of herbs in the TCM prescriptions for the treatment of coronavirus disease 2019 (COVID-19). Then, we explored the active components and core targets using network pharmacology.
Biomed Pharmacother
November 2023
Department of Urology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address:
Background: Oxidative stress and inflammatory responses are critical factors in calcium oxalate (CaOx) crystal-induced renal injury. Reactive oxygen species (ROS) are usually produced in the cytoplasm and mitochondria and trigger the priming and activation of the NLRP3 inflammasome, thereby regulating cytokines and inflammation. Polydatin is a plant rhizome extract with anti-inflammatory, antioxidant, and antitumor effects.
View Article and Find Full Text PDFPancreatology
August 2023
Univ Brest, Inserm, EFS, UMR 1078, GGB, F-29200, Brest, France. Electronic address:
Cancer Immunol Immunother
September 2023
Department of Medical Science, Genor Biopharma Co., Ltd., Shanghai, China.
Background: This study aimed to assess the efficacy and safety of geptanolimab (GB226), a fully humanized, recombinant anti-programmed cell death-1 monoclonal antibody, in Chinese patients with refractory or relapsed (r/r) primary mediastinal large B-cell lymphoma (PMBCL).
Methods: This was a multicenter, open-label, single-arm phase II study (Gxplore-003), conducted at 43 hospitals in China (NCT03639181). Patients received geptanolimab intravenously at a dose of 3 mg/kg every 2 weeks until documented confirmed disease progression, intolerable toxicity, or any other cessation criteria was met.
Zhonghua Gan Zang Bing Za Zhi
March 2023
Department of Gastroenterology, the First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China.
Sarcopenia is one of the common complications of cirrhosis. Studies have demonstrated that patients with cirrhosis combined with sarcopenia have a high mortality rate. The occurrence of sarcopenia may be associated with inflammatory states and metabolic abnormalities caused by changes in the gut microbiota environment, but such studies are currently relatively lacking.
View Article and Find Full Text PDFClin Respir J
May 2023
Department of Radiology, Beijing Cancer Hospital Affiliated to Peking University, Beijing, China.
J Vasc Surg
August 2023
Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Diagnostic Center of Vascular Ultrasound, Beijing, China.
Objective: Carotid artery stenting (CAS) has become an alternative strategy to carotid endarterectomy for carotid artery stenosis. Residual stenosis was an independent risk factor for restenosis, with the latter affecting the long-term outcomes of CAS. This multicenter study aimed to evaluate the echogenicity of plaques and hemodynamic alteration by color duplex ultrasound (CDU) examination and investigate their effects on the residual stenosis after CAS.
View Article and Find Full Text PDFTechnol Health Care
October 2023
Department of Ophthalmology, Shanxi Bethune Hospital, Taiyuan, Shanxi, China.
Background: Orbital blowout fracture is common in ocular trauma. Accurate measurement of orbital volume after fracture is key in improving intraocular correction.
Objective: This study aims to explore the impact of 3D reconstruction technology in restoring normal exophthalmos in patients with old orbital wall fractures.
J Maxillofac Oral Surg
December 2022
Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001 China.
Purpose: This study aimed to compare the differences among Piezosurgery, CAS-kit, and Osteotome regarding safe elevation, perforation rate, and time spent and to observe and analyze different sinus lifting efficacy of the three methods.
Materials And Methods: Twenty-one fresh goat heads (42 sinuses) were investigated. CBCT images confirmed the feasibility of the goat model.
Arch Osteoporos
July 2022
Department of Endocrinology, Key Laboratory of Endocrinology, NHC, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Unlabelled: The efficacy of generic teriparatide in improving BMD at lumbar spine in patients with osteoporosis was similar to that of alendronate. It provided a new choice for osteoporosis treatment in Chinese population.
Introduction: To determine whether the efficacy of generic teriparatide is noninferior to alendronate for Chinese postmenopausal women with osteoporosis.
Hematol Oncol
December 2022
Clinical Research Center, Sinocelltech Ltd, Beijing, China.
Chem Biol Interact
August 2022
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi, 030001, China; Shanxi University of Chinese Medicine, Taiyuan, Shanxi, 030619, China. Electronic address:
Excessive occupational, medical, and environmental exposure of zinc oxide nanoparticles (ZnONPs) caused its accumulation in the nervous system and raised global concerns over its detrimental effects. However, very few researches had been conducted on the impact of mitochondrial quality control process on central nervous system (CNS) after ZnONPs administration, including mitochondrial fission, fusion, biogenesis, and autophagy. In present study, mitochondrial dysfunction and apoptosis were triggered in ZnONPs-exposed human neuroblastoma SH-SY5Y cells.
View Article and Find Full Text PDFCan J Gastroenterol Hepatol
May 2022
Department of Infectious Diseases, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China.
Objective: To assess the geographic distribution of HCV genotypes, effectiveness, and safety of DAA treatment for HCV-infected patients in North and Northeast China.
Methods: The geographic distribution of HCV genotypes was analyzed in 2162 patients recruited from April 2018 to February 2021. Sustained virologic response rates at 12 (SVR12) or 24 (SVR24) weeks posttreatment and safety were analyzed in 405 patients who completed DAA treatment according to patient baseline characteristics and treatment.
Mult Scler Relat Disord
April 2022
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. Electronic address: