NOD-like receptor X1 promotes autophagy and inactivates NLR family pyrin domain containing 3 inflammasome signaling by binding autophagy-related gene 5 to alleviate cerebral ischemia/reperfusion-induced neuronal injury.

Ischemic strokes pose serious risks to human health. We aimed to elucidate the function of NOD-like receptor X1 (NLRX1) in a rat middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injury (CIRI) model and in an oxygen-glucose deprivation/reperfusion (OGD/R)-treated human microglial cell line (HMC3) model. Following NLRX1 upregulation, infarct volumes were measured with 2,3,5-triphenyltetrazolium chloride staining and pathological examination was conducted with hematoxylin-eosin staining.

Predictive model for HBsAg clearance rate in chronic hepatitis B patients treated with pegylated interferon α-2b for 48 weeks.

Background And Aims: Chronic hepatitis B (CHB) is a major global health concern. This study aims to investigate the factors influencing hepatitis B surface antigen (HBsAg) clearance in CHB patients treated with pegylated interferon α-2b (Peg-IFNα-2b) for 48 weeks and to establish a predictive model.

Methods: This analysis is based on the "OASIS" project, a prospective real-world multicenter study in China.

KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus.

Background: Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE. However, the detailed mechanisms of increased neutrophil apoptosis in SLE remain unknown.

The Effects of COVID-19 on Anxiety and Depressive Symptoms Among Chinese College Students: Chain Mediation of Three Long COVID-19 Symptoms.

Long COVID has become a public health issue, and anxiety and depressive symptoms have been on the rise among young people since the COVID-19 pandemic. The primary purpose of this study was to survey the status of COVID-19 infection, long COVID, and mental health among Chinese college students after China lifted the dynamic zero-COVID policy on December 7, 2022. The secondary purpose was to explore the mediation effect of long COVID on the relationship between COVID-19 and anxiety and depressive symptoms.

Functional connectivity of paired default mode network subregions in patients with eye trauma.

Aim: To study functional brain abnormalities in patients with eye trauma (ET) and to discuss the pathophysiological mechanisms of ET.

Methods: Totally 31 ET patients and 31 healthy controls (HCs) were recruited. The age, gender, and educational background characteristics of the two groups were similar.

Predictive value of CA-153, CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer.

Aim: To establish a meaningful standard for diagnosing ocular metastasis (OM) in menopausal breast cancer (BC) women, and explore the relationship between CA-153, CA-125, apolipoprotein A, and OM.

Methods: A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July 2022. Women with BC who are menopausal were found to have an OM incidence of 1.

Uncovering key genes and molecular mechanisms of dendritic cell dysfunction in Esophageal Cancer: implications for Novel Diagnostic and therapeutic strategies.

Dendritic cells play a crucial role in initiating and regulating immune responses, and their dysfunction is strongly associated with esophageal cancer. In this study, we aimed to develop a predictive signature and identify key genes linked to dendritic cell dysfunction in esophageal cancer. Through bioinformatics analysis of gene expression data from the TCGA database, we identified a set of 603 genes significantly associated with dendritic cell function.

Microenvironmental G protein-coupled estrogen receptor-mediated glutamine metabolic coupling between cancer-associated fibroblasts and triple-negative breast cancer cells governs tumour progression.

Background: Triple-negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein-coupled estrogen receptor (GPER), a novel estrogen receptor, is linked to increased malignancy in various cancers. However, its involvement in the metabolic regulation of cancer-associated fibroblasts (CAFs), a key component in the tumour microenvironment, remains largely unexplored.

Inflammatory Burden Index: A Superior Prognostic Biomarker of Systemic Inflammation in Patients on Peritoneal Dialysis.

Purpose: Systemic inflammation biomarkers, derived from routine blood tests, have been demonstrated to be associated with prognosis of patients undergoing peritoneal dialysis (PD). However, studies focusing on the comparisons of their role on predictive efficacy for prognosis of PD patient are limited and results are inconsistent. The purpose of this study was to evaluate the prognostic value of various systemic inflammation biomarkers and to identify the optimal one in PD patients.

Prognostic value and potential biological function of in lung adenocarcinoma.

Background: The 26S non-ATPase regulatory subunit 11 () is a multiprotein complex that participates in the ATP-dependent degradation of ubiquitinated proteins and is essential to the regulation of embryonic stem cell proteasome activity. has been demonstrated to be a factor contributing to the emergence and progression of cancer cells. However, the prognostic value and potential biological function of in lung adenocarcinoma (LUAD) remains unclear.

The establishment of an lung perfusion rat model: insights from Jiangxi, China.

The scarcity of viable donor lungs is a formidable obstacle in lung transplantation (LTx) surgery. This issue significantly hinders the availability of this life-saving procedure for patients in need. To alleviate this shortage, researchers have turned to ex vivo lung perfusion (EVLP) technology as a means to evaluate and potentially repair marginal donor lungs, thereby increasing the donor pool and improving access to transplantation.

Perioperative analgesic effect and safety of ultrasound-guided external oblique intercostal block and oblique subcostal transversus abdominis plane block in patients receiving laparoscopic radical gastrectomy.

Objective: To compare the perioperative analgesic effect and safety of ultrasound-guided external oblique intercostal (EOI) block versus oblique subcostal transversus abdominis plane (OSTAP) block in patients receiving laparoscopic radical gastrectomy.

Methods: A prospective study was conducted on sixty patients who underwent laparoscopic radical gastrectomy for gastric cancer at the First Affiliated Hospital of Nanchang University from January 2022 to September 2022. Patients were divided into the EOI block group and the OSTAP block group according to the random number table, with 30 patients in each group.

Development and external validation of a nomogram to predict the prognosis of patients with metastatic prostate cancer who underwent radiotherapy.

Background: Metastatic prostate cancer (mPCa) complicates treatment due to its unpredictable progression. Current prognostic tools often lack precision. This study aimed to develop an effective tool to predict overall survival (OS) in mPCa patients undergoing radiotherapy, thereby addressing the clinical need for personalized treatment decisions.

BRTO for ectopic small intestinal varices bleeding via dilated superior mesenteric veins and left ovarian vein: A case report.

Ectopic Variceal Bleeding is a rare complication of portal hypertension, often difficult to manage and potentially life-threatening. However, established guidelines directing treatment are lacking. This report presents a 51-year-old female with hepatitis B-related cirrhosis, who experienced rare small intestinal bleeding due to varicose veins in the superior mesenteric vein and left ovarian vein.

User-friendly prognostic model for rectal neuroendocrine tumours: In the era of precision management.

In this letter, we explore into the potential role of the recent study by Zeng . Rectal neuroendocrine tumours (rNETs) are rare, originate from peptidergic neurons and neuroendocrine cells, and express corresponding markers. Although most rNETs patients have a favourable prognosis, the median survival period significantly decreases when high-risk factors, such as larger tumours, poorer differentiation, and lymph node metastasis exist, are present.

Bruton tyrosine kinase promotes wound healing after myocardial infarction by inhibiting the transcription of u-PA.

Backgrounds: Bruton tyrosine kinase (BTK), which is highly expressed in immune cells, plays a critical role in regulating the function of macrophages. A growing body of evidence has demonstrated that the accumulation of macrophages in cardiac tissue after myocardial infarction (MI) significantly affects wound healing and ventricular remodeling during the early phase of repair after MI. However, the role of BTK in cardiac repair post-MI, especially in macrophage-mediated repair, remains unclear.

International experts consensus on optimal central vascular access device selection and management for patients with cancer.

Background: In patients with cancer, the choice of an appropriate venous access device is crucial for effective treatment, minimizing complications, and reducing healthcare costs. Key management decisions, such as the timing of device removal post-therapy, can impact clinical outcomes. As current international guidelines lack specific directives for these issues, a global consensus of experts, representing different countries, was deemed appropriate.

Comparison of clinical and para-clinical characteristics between children and adults with the Omicron variant of COVID-19.

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is associated with higher transmissibility, but lower disease severity, compared to some other variants. However, its exact pathogenicity among children is still largely unknown. This study was conducted to determine the differences in clinical characteristics between children and adults infected with this variant.

Serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury.

Traumatic brain injury (TBI) induces significant neuroinflammation, primarily driven by microglia. Neonatal microglia (NMG) may have therapeutic potential by modulating the inflammatory response of damaged adult microglia (AMG). This study investigates the influence of NMG on AMG function through extracellular matrix (ECM) remodeling and the formation of tunneling nanotubes (TnTs), with a focus on the role of Serpina3n.