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Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension.
Exp Lung Res
June 2016
a Department of Respiratory Medicine, the First Affiliated Hospital of Medical College at Xi'an JiaoTong University, Xi'an , Shanxi , China.
It has been shown that activation of Notch3 signaling is involved in the development of pulmonary arterial hypertension (PAH) by stimulating pulmonary arteries remodeling, while the molecular mechanisms underlying this are still largely unknown. The aims of this study are to address these issues. Monocrotaline dramatically increased right ventricle systolic pressure to 39.
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