2 results match your criteria: "the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6[Affiliation]"
UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b.
J Virol
September 2022
Department of Cell Biology, School of Life Sciences, Central South Universitygrid.216417.7, Changsha, China.
Article Synopsis
- Three human coronaviruses have emerged over the last two decades—SARS-CoV, MERS-CoV, and SARS-CoV-2—creating significant health and economic challenges that drive research into their characteristics and treatments.
- MERS-CoV's ORF4b protein can suppress the immune response but is unstable and degraded by the host's ubiquitin proteasome system, specifically regulated by the UBR5 protein.
- UBR5 diminishes ORF4b’s anti-immunity effects, thereby inhibiting MERS-CoV's ability to evade the immune system, showcasing a new mechanism through which host cells combat this virus.
The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus.
J Virol
February 2022
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Middle East respiratory syndrome coronavirus (MERS-CoV) is a beta coronavirus that emerged in 2012, causing severe pneumonia and renal failure. MERS-CoV encodes five accessory proteins. Some of them have been shown to interfere with host antiviral immune response.
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