Oligomannosidic glycans at Asn-110 are essential for secretion of human diamine oxidase.

-Glycosylation plays a fundamental role in many biological processes. Human diamine oxidase (hDAO), required for histamine catabolism, has multiple glycosylation sites, but their roles, for example in DAO secretion, are unclear. We recently reported that the glycosylation sites Asn-168, Asn-538, and Asn-745 in recombinant hDAO (rhDAO) carry complex-type glycans, whereas Asn-110 carries only mammalian-atypical oligomannosidic glycans.