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Identification of the Molecular and Genetic Basis of PX2, a Glycosphingolipid Blood Group Antigen Lacking on Globoside-deficient Erythrocytes.

J Biol Chem

July 2015

From the Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, SE-22184 Lund, Sweden, the Clinical Immunology and Transfusion Medicine, Laboratory Medicine, Office of Medical Services, Region Skåne, SE-22185 Lund, Sweden,

The x2 glycosphingolipid is expressed on erythrocytes from individuals of all common blood group phenotypes and elevated on cells of the rare P/P1/P(k)-negative p blood group phenotype. Globoside or P antigen is synthesized by UDP-N-acetylgalactosamine:globotriaosyl-ceramide 3-β-N-acetylgalactosaminyltransferase encoded by B3GALNT1. It is the most abundant non-acid glycosphingolipid on erythrocytes and displays the same terminal disaccharide, GalNAcβ3Gal, as x2.

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