Radiative Warming Glass for High-Latitude Cold Regions.

Traditional window glazing, with inherently adverse energy-efficient optical properties, leads to colossal energy losses. Energy-saving glass requires a customized optical design for different climate zones. Compared with the widely researched radiative cooling technology which is preferable to be used in low-altitude hot regions; conversely in high-latitude cold regions, high solar transmittance (T) and low mid-infrared thermal emissivity (ε) are the key characteristics of high-performance radiative warming window glass, while the current low-emissivity (low-e) glass is far from ideal.

SOS2 phosphorylates FREE1 to regulate multi-vesicular body trafficking and vacuolar dynamics under salt stress.

Salt stress causes ion toxicity in plant cells and limits plant growth and crop productivity. Sodium ions (Na+) are transported out of the cell and sequestered in the vacuole for detoxification under salt stress. The salt excretion system is controlled by the SALT OVERLY SENSITIVE (SOS) pathway, which consists of the calcium sensors SOS3 and SOS3-LIKE CALCIUM BINDING PROTEIN 8, the protein kinase SOS2, and the plasma membrane Na+/H+ antiporter SOS1.

Variations and Opportunities in Postnatal Management of Hemolytic Disease of the Fetus and Newborn.

Importance: Preventive efforts in pregnancy-related alloimmunization have considerably decreased the prevalence of hemolytic disease of the fetus and newborn (HDFN). International studies are therefore essential to obtain a deeper understanding of the postnatal management and outcomes of HDFN. Taken together with numerous treatment options, large practice variations among centers may exist.

Concomitant Usage of H1-Antihistamines and Immune Checkpoint Inhibitors on Cancer Patient Survival.

Purpose: Recent research (Li et al. 2021) suggests an upregulated expression and activation of H1 receptors on macrophages in the tumor microenvironment, and concomitant H1-antihistamine use is associated with improved overall survival in patients with lung and skin cancers receiving immunotherapy. Therefore, we retrospectively evaluated the impacts of H1-antihistamine use in cancer patients during immunotherapy.

Country-specific key lifestyle factors and health outcomes for resource allocation in the general population: a network analysis across 29 countries.

Background: We aimed to identify the central lifestyle, the most impactful among lifestyle factor clusters; the central health outcome, the most impactful among health outcome clusters; and the bridge lifestyle, the most strongly connected to health outcome clusters, across 29 countries to optimise resource allocation for local holistic health improvements.

Methods: From July 2020 to August 2021, we surveyed 16 461 adults across 29 countries who self-reported changes in 18 lifestyle factors and 13 health outcomes due to the pandemic. Three networks were generated by network analysis for each country: lifestyle, health outcome, and bridge networks.

Trend of Representation of Women in Gastroenterology, Hepatology, and Endoscopy Conferences in Asia.

Objectives: Despite progress in promoting gender equality, gender bias remains a significant obstacle for women and hinders their academic advancement. We aim to survey and critically analyze women's representation in conferences and changes over time in various regions of Asian countries.

Methods: An international survey was conducted with representatives from East Asia (Hong Kong, China, and Japan), South Asia (India and Pakistan), and Southeast Asia (Vietnam and Thailand).

Disease Severity, Illness Perceptions, Depression and Health-Related Quality of Life in Patients With Heart Failure.

Background: Disease severity negatively affects health-related quality of life (HRQOL) among people with heart failure (HF). However, the underlying mechanisms remain underexplored. Illness perceptions and depression serve as potential mediators of this relationship, but the evidence supporting this is limited.

Unraveling the Synergistic Neuroprotective Mechanism of Natural Drug Candidates Targeting TRPV1 and TRPM8 on an Ischemic Stroke.

The development of multitargeted drugs is urgent for ischemic stroke. TRPV1 and TRPM8 are important targets of ischemic stroke. Previous drug candidate screening has identified that muscone, l-borneol, and ferulic acid may target TRPV1 and TRPM8 for ischemic stroke.

Mind the gap in kidney care: Translating what we know into what we do.

Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do.

Relationships between perceived physical literacy and mental health in tertiary education students: a scoping review.

Background/objective: Physical literacy (PL) is "the motivation, confidence, physical competence, knowledge, and understanding to value and take responsibility for engagement in physical activities for life". Recent evidence has shown that PL was associated with mental wellbeing in different populations, yet a comprehensive review examining the association between PL and mental health among tertiary education students was lacking. The aims of this scoping review were to rapidly map relevant evidence on the relationships between perceived PL and mental health in higher education students and to determine the feasibility and value of conducting a full systematic review in this research area.

Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation.

Pseudouridine (Ψ) is the most abundant RNA modification, yet studies of Ψ have been hindered by a lack of robust methods to profile comprehensive Ψ maps. Here we utilize bisulfite-induced deletion sequencing to generate transcriptome-wide Ψ maps at single-base resolution across various plant species. Integrating ribosomal RNA, transfer RNA and messenger RNA Ψ stoichiometry with mRNA abundance and polysome profiling data, we uncover a multilayered regulation of translation efficiency through Ψ modifications.

Mobile health applications for older people in Asia: protocol for a systematic review of end-user perceptions and recommendations.

Introduction: Mobile technology has revolutionised the way people interact with others and gain access to healthcare services. Given that cultural background is a strong moderator for technology penetration, this systematic review aims to examine end-user perceptions and design recommendations for mobile health applications among Asian older people.

Methods And Analysis: Five electronic databases (PubMed, CINAHL, PsycINFO, Medline and Cochrane Central Register of Controlled Trials) will be searched until May 2025.

Spliced exon9 ADRM1 promotes liver oncogenicity via selective degradation of tumor suppressor FBXW7.

Background & Aims: The ubiquitin receptor ADRM1/Rpn13 governs the specificity of eukaryotic protein degradation. By SMRT sequencing, we first discovered a novel spliced variant of ADRM1 with a skipped exon 9, termed ADRM1-ΔEx9, in human hepatocellular carcinoma (HCC). This study aimed to elucidate this novel ubiquitin receptor's underlying biology and clinical implications in HCC.

pksE. coli adhesins-The fine line between good and evil.

Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of Nature, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E.

StackDILI: Enhancing Drug-Induced Liver Injury Prediction through Stacking Strategy with Effective Molecular Representations.

Drug-induced liver injury (DILI) is a major challenge in drug development, often leading to clinical trial failures and market withdrawals due to liver toxicity. This study presents StackDILI, a computational framework designed to accelerate toxicity assessment by predicting DILI risk. StackDILI integrates multiple molecular descriptors to extract structural and physicochemical features, including the constitution, pharmacophore, MACCS, and E-state descriptors.

Protein alterations in patients with delirium after cardiac surgery: An exploratory case-control sub-study of the VISION Cardiac Surgery Biobank.

Background: Delirium is an acute state of confusion associated with adverse postoperative outcomes. Delirium is diagnosed clinically using screening tools; most cases go undetected. Identifying a delirium biomarker would allow for accurate diagnosis, application of therapies, and insight into causal pathways.

Prognostic and therapeutic implications of measurable residual disease levels during remission induction of childhood ALL.

We evaluated the prognostic and therapeutic significance of measurable residual disease (MRD) during remission induction in pediatric acute lymphoblastic leukemia (ALL) patients. In the CCCG-ALL-2015 protocol, 7640 patients were categorized into low-, intermediate-, or high-risk groups based on clinical and genetic features. Final risk classification was determined by MRD assessed via flow cytometry on Days 19 and 46 of remission induction, with additional intensified chemotherapy for Day 19 MRD ≥1%.

Automated Detection of Isolated REM Sleep Behavior Disorder Using Computer Vision.

Objective: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early stage of Parkinson's disease or related disorders. Diagnosis requires an overnight video-polysomnogram (vPSG), however, even for sleep experts, interpreting vPSG data is challenging. Using a 3D camera, automated analysis of movements has yielded high accuracy.

Identification of high‐performance blood‐based biomarkers for early screening and staging of Alzheimer’s disease by large‐scale plasma proteomic profiling in mild cognitive impairments.

Background: Early detection of Alzheimer's disease (AD), particularly during the mild cognitive impairment (MCI) stage, is crucial for effective intervention and treatment. However, existing diagnostic methods, through cognitive assessments, brain imaging, or cerebrospinal fluid profiling, are subjective, expensive or invasive. We previously showed that the plasma proteome is altered in AD, suggesting the feasibility of utilizing blood biomarkers for AD detection.

Development of a robust blood‐based multi‐pathway biomarker assay for early screening and classification of Alzheimer’s disease.

Background: Alzheimer's disease (AD) is a devastating neurodegenerative disease with delayed diagnosis until the manifestation of symptoms. Although the emergence of blood‐based biomarkers offers hope for easy detection of AD, existing AD‐associated blood biomarkers, known as the “blood ATN biomarkers”, mainly capture the pathological hallmarks of AD, overlooking other AD‐associated biological processes such as inflammation and vascular dysfunctions. Therefore, developing a blood‐based biomarker assay that captures dysregulation beyond the ATN biomarkers may help advance early detection and staging of AD, enabling a comprehensive examination of the disease status

Method: We leveraged ultrasensitive proteomic technology to develop a blood‐based, multiplex biomarker assay for AD.

Caregiving experience and service utilization of informal caregivers for community‐living older adults with neurocognitive disorders: preliminary findings in Hong Kong.

Background: Caring for people with dementia in communities inevitably brings heavy burden for their family caregivers. Senses of positive aspects from caring and proper service support may help shape a healthy care journey for carers. This study aims to evaluate the caregiving burden, positive aspects, and service utilization of informal caregivers for community‐living older adults with neurocognitive disorders (NCDs).

Effect of increasing cognitive activity participation on functional connectivities within default mode network– a randomized controlled trial.

Background: We previously reported that increasing participation in Chinese calligraphy handwriting, one of the “Four Arts” traditionally mastered by intellectuals in China and currently widely practiced by older adults in the Chinese community, led to better working memory among individuals with subjective cognitive decline (but without mild or major neurocognitive disorder). Given that the default mode network (DMN) is closely correlated with the clinical symptoms and progression of Alzheimer’s disease, we aimed to investigate the effect of increasing calligraphy practice on the DMN.

Method: Community‐living older adults who had been practicing Chinese calligraphy handwriting regularly (at least one hour of calligraphy practice per week) and experiencing subjective cognitive decline (but without mild or major neurocognitive disorder) were randomly allocated into either the control group, where they continued their usual practice of calligraphy, or the intervention group, where they doubled their amount of practice for 6 months.

Dynamic Changes in Quantitative MRI‐based Biomarkers and Its Association with Pathology of Alzheimer’s Disease – A Longitudinal Study.

Background: Alzheimer’s disease (AD) resemblance atrophy index (AD‐RAI) is a novel MRI‐based machine‐learning derived biomarker for AD that is valid in the detection of early AD. We aimed to investigate the association between the serial change of AD‐RAI and cognitive progression overtime among cognitively unimpaired (CU) and mild cognitive impairment (MCI) subjects with and without A+T+ (i.e.