221 results match your criteria: "the Affiliated Zhongshan Hospital[Affiliation]"

Background: In recent years, the demand for facial rejuvenation is increasing year by year. This study aims to use bibliometric analysis to construct a visualization map of the facial rejuvenation research and provide the research hotspots and trend frontiers in the field.

Methods: Publications on facial rejuvenation research were extracted from the Web of Science Core Collection database.

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Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis. Dysregulation of 5-Methylcytosine (mC) RNA has gradually been reported in various cancers, but their role in tumor diagnosis is rarely mentioned. Our study aimed to determine the role of mC methylation modification in blood immune cells for the diagnosis of CRC.

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[Current clinical application of lacrimal gland injection of botulinum toxin type A in inhibiting lacrimal secretion].

Zhonghua Yan Ke Za Zhi

September 2022

Lacrimal Center, Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100039, China.

Lacrimal gland injection of botulinum toxin type A inhibits the secretion of tears. As a new method to treat or alleviate the symptom of tears or epiphora, it has the characteristics of simple operation, definite curative effect, repeatable treatment and no irreversible complications. It provides an optional treatment scheme for many patients with refractory tears or epiphora.

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Type 1 diabetes mellitus (T1DM) is a type of diabetes caused by the destruction of pancreatic β cells and the absolute lack of insulin secretion. T1DM usually starts in adolescence or develops directly as a severe disease state of ketoacidosis. T1DM and its complications make many people suffer and have psychological problems, which make us have to pay more attention to the prevention and early control of T1DM.

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Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH.

Phytochemistry

November 2022

College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Dalian, 116044, People's Republic of China. Electronic address:

Article Synopsis
  • Ganoderma lucidum is an edible mushroom that's also used for medicine.
  • Researchers found 29 special compounds in it, including 11 new ones, which can help with health.
  • These compounds may reduce inflammation in the brain and don't harm cancer cells, making the mushroom useful for food or medicine.
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PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α.

Exp Cell Res

September 2022

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, 116027, China. Electronic address:

PLIN2 has been found to be dysregulated in several human malignancies, which influences cancer progression. However, the roles of PLIN2 in regulating hepatocellular carcinoma (HCC) progression are still unclear. Here, we revealed that PLIN2 was frequently upregulated in HCC cells and tissues, and increased PLIN2 expression was associated with poor prognosis outcomes in HCC.

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Elevated circASCC3 limits antitumor immunity by sponging miR-432-5p to upregulate C5a in non-small cell lung cancer.

Cancer Lett

September 2022

Department of Thoracic Surgery, The Affiliated Zhongshan Hospital of Fudan University, Shanghai, 200032, PR China; Cancer Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, PR China. Electronic address:

Although anti-programmed cell death 1 (PD1) treatment has become a first-line therapy for advanced non-small cell lung cancer (NSCLC), most NSCLC patients are refractory to anti-PD1. Here, we aimed to investigate the mechanism of dysregulated circular RNAs (circRNAs) related to anti-PD1 resistance in NSCLC. The expression of circASCC3 (hsa_circ_0077,495) in NSCLC tissues and cell lines was evaluated by fluorescence in situ hybridization and quantitative reverse transcription-polymerase chain reaction.

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Two new nor-triterpenoids ganodrenol A (), B (), and a new natural product ganodrenol C (), along with three known nor-triterpenoids (-) were isolated from the fruiting bodies of The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (-) against FAAH were evaluated by an in assay, and compound showed an inhibition rate of 70.27%.

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Background: Previous studies have confirmed the oncogenic role of HMGB2 in various cancers, but the biological functions of HMGB2-derived circRNAs remain unknown. Thus, we intended to investigate the potential role of HMGB2-derived circRNAs in lung adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC).

Methods: The expression profiles of HMGB2-derived circRNAs in LUAD and LUSC tissues and matched normal tissues were assessed using qRT-PCR.

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Background: is a type of soft tissue sarcoma, the histologic origin and differentiation direction of which are still unclear. There are few treatment options for other than surgery. Herein we describe a patient who had multiple recurrences of postoperatively, but R0 resection was achieved by local hyperthermia combined with chemotherapy, thus providing a new treatment approach for similar situations.

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Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world with a five-year survival rate of less than 20%. Nonetheless, selecting an appropriate therapeutic agent to inhibit the development of hepatoma cells is still a challenge. Bufalin, a component of the traditional Chinese medicine Chansu, has been shown to inhibit the proliferation, invasion and metastasis of HCC through various signaling pathways.

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Sacubitril/valsartan, simultaneously inhibits neprilysin and angiotensin II receptor, showed an effect in reducing blood pressure (BP). The authors aimed to study whether it can be used as an antihypertensive agent in patients with refractory hypertension who have already been treated. A total of 66 Chinese patients with refractory hypertension were enrolled.

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Effects of gene silencing on cell cycle and apoptosis in the metastatic renal carcinoma cell line ACHN.

J Int Med Res

February 2022

Department of Urology Surgery, 66562Affiliated Zhongshan Hospital of Dalian University, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China.

Objective: To explore the role of high mobility group AT-hook 2 (HMGA2) in the regulation of the cell cycle and apoptosis.

Methods: The renal carcinoma cell line ACHN was transiently transfected with small interfering RNA to knock down the expression of the gene. Cell cycle analysis was undertaken using flow cytometry.

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Altered circadian clock gene expression in the sperm of infertile men with asthenozoospermia.

J Assist Reprod Genet

January 2022

Department of Reproductive Medicine Center, The Affiliated Zhongshan Hospital, Dalian University, Dalian, 116021, People's Republic of China.

Purpose: Male infertility is a complex multifactorial pathological condition, and asthenozoospermia (AZS) is one of the most common causes. Current evidence suggests the underlying role of the circadian clock on male fertility. This study aims to evaluate the expression levels of five principal clock genes in the sperm and their correlations with the sperm parameters in male infertility.

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Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis.

J Inflamm Res

December 2021

Department of Food Nutrition and Safety, School of Public Health, Dalian Medical University, Dalian, Liaoning, People's Republic of China.

Inflammation is an intricate biological response of body tissues to detrimental stimuli. Cardiovascular disease (CVD) is the leading cause of death worldwide, and inflammation is well documented to play a role in the development of CVD, especially atherosclerosis (AS). Emerging evidence suggests that activation of the NOD-like receptor (NLR) family and the pyridine-containing domain 3 (NLRP3) inflammasome is instrumental in inflammation and may result in AS.

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Breast cancer (BC), an extremely aggressive malignant tumor, causes a large number of deaths worldwide. In this study, we pooled profile datasets from three cohorts to illuminate the underlying key genes and pathways of BC. Expression profiles GSE42568, GSE45827, and GSE124646, including 244 BC tissues and 28 normal breast tissues, were integrated and analyzed.

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Preparation of Cationic Amphiphilic Nanoparticles with Modified Chitosan Derivatives for Doxorubicin Delivery.

Materials (Basel)

November 2021

Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

Polymeric micelle-like nanoparticles have demonstrated effectiveness for the delivery of some poorly soluble or hydrophobic anticancer drugs. In this study, a hydrophobic moiety, deoxycholic acid (DCA) was first bonded on a polysaccharide, chitosan (CS), for the preparation of amphiphilic chitosan (CS-DCA), which was further modified with a cationic glycidyltrimethylammounium chloride (GTMAC) to form a novel soluble chitosan derivative (HT-CS-DCA). The cationic amphiphilic HT-CS-DCA was easily self-assembled to micelle-like nanoparticles about 200 nm with narrow size distribution (PDI 0.

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Anti-γ-aminobutyric acid type β receptor (anti-GABAR) antibody-associated encephalitis is a type of autoimmune encephalitis. According to current literature, its pathogenesis is reported to be closely related to tumor factors. However, diagnosis can be difficult because of the rarity of cases, limited clinical understanding, and a lack of specificity in clinical manifestation and imaging presentation.

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Linc00467 promotion of gastric cancer development by directly regulating miR-7-5p expression and downstream epidermal growth factor receptor.

Bioengineered

December 2021

Department of Gastrointestinal Surgery, The Affiliated Zhongshan Hospital of Xiamen University; Institute of Gastrointestinal Oncology, Medical College of Xiamen University, Xiamen, China.

Linc00467 is a vital regulator in tumor progression. This study explores the molecular mechanisms of linc00467 in gastric cancer (GC). Linc00467 expression was obtained and analyzed in GC tissue through exploration in the cancer genome atlas database.

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The established criteria for determining whether to excise the cardia during laparoscopic surgery for gastrointestinal stromal tumors in the esophagogastric junction (EGJ-GISTs) remain controversial. This retrospective multicenter study was conducted to develop a nomogram for predicting the risk of the cardia excision during laparoscopic surgery for EGJ-GISTs. We reviewed data from 2,127 gastric-GISTs (g-GISTs) patients without distant metastases in four hospital between June 2012 and June 2020.

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Effective biomarkers for the diagnosis of colorectal cancer (CRC) are essential for improving prognosis. Imbalance in regulation of N6-methyladenosine (mA) RNA has been associated with a variety of cancers. However, whether the mA RNA levels of peripheral blood can serve as a diagnostic biomarker for CRC is still unclear.

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Objective: The aim of the present study was to assess the effect of suspension fixation with button plates on the reconstruction of the distal radioulnar joint dislocation (DRUJ).

Methods: This was a case series of six patients (two men and four women) who underwent suspension fixation with button plates for DRUJ dislocation between January 2015 and May 2017. Physical examination, radiography, MRI, functional activity of the wrist joint, grip strength of the wrist joint, Garland-Werley wrist score, Mayo wrist score, and visual analog scale (VAS) score were used to evaluate the effect of this procedure.

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An outstanding role of novel virus-like heterojunction nanosphere BOCO@Ag as high performance antibacterial activity agent.

J Hazard Mater

January 2022

School of Medicine, Xiamen University, Xiamen, Fujian 361002, China; Department of Oncology, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen 361004, Fujian, China; Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Xiamen 361004, Fujian, China; Xiamen Municipal Key Laboratory of Gastrointestinal Oncology, Xiamen 361004, Fujian, China. Electronic address:

The development of highly efficient photonic nanomaterials with synergistic biological effects is critical and challenging task for public hygiene health well-being and has attracted extensive interest. In this study, a type of near-infrared (NIR) driven, virus-like heterojunction was first developed for synergistic biological application. The Ag-coated BiCO nanomaterial (BOCO@Ag) demonstrated good biocompatibility, low cytotoxicity, high antibacterial activity and excellent light utilization stability.

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