221 results match your criteria: "the Affiliated Zhongshan Hospital[Affiliation]"
Aesthetic Plast Surg
June 2023
The Second Affiliated Hospital of Dalian Medical University in China, 467 Zhongshan Rd, Shahekou district, Dalian, Liaoning, China.
Background: In recent years, the demand for facial rejuvenation is increasing year by year. This study aims to use bibliometric analysis to construct a visualization map of the facial rejuvenation research and provide the research hotspots and trend frontiers in the field.
Methods: Publications on facial rejuvenation research were extracted from the Web of Science Core Collection database.
Front Immunol
October 2022
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis. Dysregulation of 5-Methylcytosine (mC) RNA has gradually been reported in various cancers, but their role in tumor diagnosis is rarely mentioned. Our study aimed to determine the role of mC methylation modification in blood immune cells for the diagnosis of CRC.
View Article and Find Full Text PDFZhonghua Yan Ke Za Zhi
September 2022
Lacrimal Center, Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100039, China.
Lacrimal gland injection of botulinum toxin type A inhibits the secretion of tears. As a new method to treat or alleviate the symptom of tears or epiphora, it has the characteristics of simple operation, definite curative effect, repeatable treatment and no irreversible complications. It provides an optional treatment scheme for many patients with refractory tears or epiphora.
View Article and Find Full Text PDFHeliyon
August 2022
Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, PR China.
Type 1 diabetes mellitus (T1DM) is a type of diabetes caused by the destruction of pancreatic β cells and the absolute lack of insulin secretion. T1DM usually starts in adolescence or develops directly as a severe disease state of ketoacidosis. T1DM and its complications make many people suffer and have psychological problems, which make us have to pay more attention to the prevention and early control of T1DM.
View Article and Find Full Text PDFPhytochemistry
November 2022
College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Dalian, 116044, People's Republic of China. Electronic address:
Exp Cell Res
September 2022
Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, 116027, China. Electronic address:
PLIN2 has been found to be dysregulated in several human malignancies, which influences cancer progression. However, the roles of PLIN2 in regulating hepatocellular carcinoma (HCC) progression are still unclear. Here, we revealed that PLIN2 was frequently upregulated in HCC cells and tissues, and increased PLIN2 expression was associated with poor prognosis outcomes in HCC.
View Article and Find Full Text PDFCancer Lett
September 2022
Department of Thoracic Surgery, The Affiliated Zhongshan Hospital of Fudan University, Shanghai, 200032, PR China; Cancer Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, PR China. Electronic address:
Although anti-programmed cell death 1 (PD1) treatment has become a first-line therapy for advanced non-small cell lung cancer (NSCLC), most NSCLC patients are refractory to anti-PD1. Here, we aimed to investigate the mechanism of dysregulated circular RNAs (circRNAs) related to anti-PD1 resistance in NSCLC. The expression of circASCC3 (hsa_circ_0077,495) in NSCLC tissues and cell lines was evaluated by fluorescence in situ hybridization and quantitative reverse transcription-polymerase chain reaction.
View Article and Find Full Text PDFNat Prod Res
February 2023
Department of Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, People's Republic of China.
Two new nor-triterpenoids ganodrenol A (), B (), and a new natural product ganodrenol C (), along with three known nor-triterpenoids (-) were isolated from the fruiting bodies of The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (-) against FAAH were evaluated by an in assay, and compound showed an inhibition rate of 70.27%.
View Article and Find Full Text PDFMol Cancer
May 2022
Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Background: Previous studies have confirmed the oncogenic role of HMGB2 in various cancers, but the biological functions of HMGB2-derived circRNAs remain unknown. Thus, we intended to investigate the potential role of HMGB2-derived circRNAs in lung adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC).
Methods: The expression profiles of HMGB2-derived circRNAs in LUAD and LUSC tissues and matched normal tissues were assessed using qRT-PCR.
World J Clin Cases
March 2022
Hyperthermia Center, The Affiliated Zhongshan Hospital of Dalian University, Dalian 110006, China.
Background: is a type of soft tissue sarcoma, the histologic origin and differentiation direction of which are still unclear. There are few treatment options for other than surgery. Herein we describe a patient who had multiple recurrences of postoperatively, but R0 resection was achieved by local hyperthermia combined with chemotherapy, thus providing a new treatment approach for similar situations.
View Article and Find Full Text PDFOnco Targets Ther
March 2022
Department of Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, People's Republic of China.
Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world with a five-year survival rate of less than 20%. Nonetheless, selecting an appropriate therapeutic agent to inhibit the development of hepatoma cells is still a challenge. Bufalin, a component of the traditional Chinese medicine Chansu, has been shown to inhibit the proliferation, invasion and metastasis of HCC through various signaling pathways.
View Article and Find Full Text PDFJ Clin Hypertens (Greenwich)
April 2022
Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Sacubitril/valsartan, simultaneously inhibits neprilysin and angiotensin II receptor, showed an effect in reducing blood pressure (BP). The authors aimed to study whether it can be used as an antihypertensive agent in patients with refractory hypertension who have already been treated. A total of 66 Chinese patients with refractory hypertension were enrolled.
View Article and Find Full Text PDFJ Int Med Res
February 2022
Department of Urology Surgery, 66562Affiliated Zhongshan Hospital of Dalian University, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China.
Objective: To explore the role of high mobility group AT-hook 2 (HMGA2) in the regulation of the cell cycle and apoptosis.
Methods: The renal carcinoma cell line ACHN was transiently transfected with small interfering RNA to knock down the expression of the gene. Cell cycle analysis was undertaken using flow cytometry.
J Assist Reprod Genet
January 2022
Department of Reproductive Medicine Center, The Affiliated Zhongshan Hospital, Dalian University, Dalian, 116021, People's Republic of China.
Purpose: Male infertility is a complex multifactorial pathological condition, and asthenozoospermia (AZS) is one of the most common causes. Current evidence suggests the underlying role of the circadian clock on male fertility. This study aims to evaluate the expression levels of five principal clock genes in the sperm and their correlations with the sperm parameters in male infertility.
View Article and Find Full Text PDFJ Inflamm Res
December 2021
Department of Food Nutrition and Safety, School of Public Health, Dalian Medical University, Dalian, Liaoning, People's Republic of China.
Inflammation is an intricate biological response of body tissues to detrimental stimuli. Cardiovascular disease (CVD) is the leading cause of death worldwide, and inflammation is well documented to play a role in the development of CVD, especially atherosclerosis (AS). Emerging evidence suggests that activation of the NOD-like receptor (NLR) family and the pyridine-containing domain 3 (NLRP3) inflammasome is instrumental in inflammation and may result in AS.
View Article and Find Full Text PDFBioengineered
December 2021
Department of Radiation Oncology, The Second Hospital of Dalian Medical University, Dalian, P.R. China.
Breast cancer (BC), an extremely aggressive malignant tumor, causes a large number of deaths worldwide. In this study, we pooled profile datasets from three cohorts to illuminate the underlying key genes and pathways of BC. Expression profiles GSE42568, GSE45827, and GSE124646, including 244 BC tissues and 28 normal breast tissues, were integrated and analyzed.
View Article and Find Full Text PDFMaterials (Basel)
November 2021
Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Polymeric micelle-like nanoparticles have demonstrated effectiveness for the delivery of some poorly soluble or hydrophobic anticancer drugs. In this study, a hydrophobic moiety, deoxycholic acid (DCA) was first bonded on a polysaccharide, chitosan (CS), for the preparation of amphiphilic chitosan (CS-DCA), which was further modified with a cationic glycidyltrimethylammounium chloride (GTMAC) to form a novel soluble chitosan derivative (HT-CS-DCA). The cationic amphiphilic HT-CS-DCA was easily self-assembled to micelle-like nanoparticles about 200 nm with narrow size distribution (PDI 0.
View Article and Find Full Text PDFOnco Targets Ther
November 2021
Department of Medical Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, People's Republic of China.
Anti-γ-aminobutyric acid type β receptor (anti-GABAR) antibody-associated encephalitis is a type of autoimmune encephalitis. According to current literature, its pathogenesis is reported to be closely related to tumor factors. However, diagnosis can be difficult because of the rarity of cases, limited clinical understanding, and a lack of specificity in clinical manifestation and imaging presentation.
View Article and Find Full Text PDFBioengineered
December 2021
Department of Gastrointestinal Surgery, The Affiliated Zhongshan Hospital of Xiamen University; Institute of Gastrointestinal Oncology, Medical College of Xiamen University, Xiamen, China.
Linc00467 is a vital regulator in tumor progression. This study explores the molecular mechanisms of linc00467 in gastric cancer (GC). Linc00467 expression was obtained and analyzed in GC tissue through exploration in the cancer genome atlas database.
View Article and Find Full Text PDFFront Surg
October 2021
Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
The established criteria for determining whether to excise the cardia during laparoscopic surgery for gastrointestinal stromal tumors in the esophagogastric junction (EGJ-GISTs) remain controversial. This retrospective multicenter study was conducted to develop a nomogram for predicting the risk of the cardia excision during laparoscopic surgery for EGJ-GISTs. We reviewed data from 2,127 gastric-GISTs (g-GISTs) patients without distant metastases in four hospital between June 2012 and June 2020.
View Article and Find Full Text PDFChin Med J (Engl)
October 2021
Department of Sports Medicine, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, China.
Front Immunol
February 2022
Digestive Medicine Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Effective biomarkers for the diagnosis of colorectal cancer (CRC) are essential for improving prognosis. Imbalance in regulation of N6-methyladenosine (mA) RNA has been associated with a variety of cancers. However, whether the mA RNA levels of peripheral blood can serve as a diagnostic biomarker for CRC is still unclear.
View Article and Find Full Text PDFOrthop Surg
October 2021
Division of Joint Surgery, Department of Orthopaedic Surgery, The Affiliated Zhongshan Hospital of Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
Objective: The aim of the present study was to assess the effect of suspension fixation with button plates on the reconstruction of the distal radioulnar joint dislocation (DRUJ).
Methods: This was a case series of six patients (two men and four women) who underwent suspension fixation with button plates for DRUJ dislocation between January 2015 and May 2017. Physical examination, radiography, MRI, functional activity of the wrist joint, grip strength of the wrist joint, Garland-Werley wrist score, Mayo wrist score, and visual analog scale (VAS) score were used to evaluate the effect of this procedure.
J Hazard Mater
January 2022
School of Medicine, Xiamen University, Xiamen, Fujian 361002, China; Department of Oncology, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen 361004, Fujian, China; Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Xiamen 361004, Fujian, China; Xiamen Municipal Key Laboratory of Gastrointestinal Oncology, Xiamen 361004, Fujian, China. Electronic address:
The development of highly efficient photonic nanomaterials with synergistic biological effects is critical and challenging task for public hygiene health well-being and has attracted extensive interest. In this study, a type of near-infrared (NIR) driven, virus-like heterojunction was first developed for synergistic biological application. The Ag-coated BiCO nanomaterial (BOCO@Ag) demonstrated good biocompatibility, low cytotoxicity, high antibacterial activity and excellent light utilization stability.
View Article and Find Full Text PDFBone
December 2021
Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, PR China. Electronic address: