328 results match your criteria: "the Affiliated People's Hospital of Jiangsu University[Affiliation]"

Impaired nutritional status is closely related to the development of sarcopenia and poor quality of life (QoL) in cancer patients. This study aimed to investigate the association of Geriatric Nutritional Risk Index (GNRI) with sarcopenia and QoL in patients with gastric cancer (GC). Sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia 2019 criteria.

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Abnormalities in rich-club connections are associated with an exacerbation of genetic susceptibility to schizophrenia.

BMC Psychiatry

December 2024

The Affiliated People's Hospital of Jiangsu University, Zhenjiang First People's Hospital, No.8, Dianli Road, Zhenjiang, 212002, Jiangsu, China.

Background: Schizophrenia (SZ) is a highly heritable and heterogeneous disorder that is often associated with widespread structural brain abnormalities. However, the causes of interindividual differences in genetic susceptibility remain largely unknown. This study attempted to address this important issue by utilizing a prospective study in which unaffected first-degree relatives of SZ (FH+) were recruited.

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Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time.

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Background: Postoperative complications are prone to occur in patients after radical pancreaticoduodenectomy (PD). This study aimed to construct and validate a model for predicting postoperative major complications in patients after PD.

Methods: The clinical data of 360 patients who underwent PD were retrospectively collected from two centers between January 2019 and December 2023.

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Mir-615-3p promotes osteosarcoma progression via the SESN2/AMPK/mTOR pathway.

Cancer Cell Int

December 2024

Department of Orthopedics, Changzhou Medical Center, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, 213003, China.

Background: Osteosarcoma (OS) is the most common primary malignant bone neoplasm. Growing researches have highlighted the tumor promoting role of miR-615-3p in various cancers. Notwithstanding, the biological function and underlying mechanisms of miR-615-3p in OS development still unclear.

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Objective: In this cross-sectional study including patients with type 2 diabetes mellitus (T2DM) we aimed to explore the relationship between serum 25-hydroxy vitamin (25(OH)D) level and liver steatosis and fibrosis in the Chinese population.

Methods: Patients visiting 16 clinical centers with T2DM were recruited. Their liver steatosis and fibrosis status were then assessed using elastography.

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Background: Transient receptor potential canonical 6 (TRPC6), a key member of the TRPC family, is involved in diverse physiological and pathological processes. Although previous studies have implicated TRPC6 in the progression of stomach adenocarcinoma (STAD), its precise functions and mechanisms remain unclear. Understanding TRPC6's role in STAD may provide insights into its prognostic and therapeutic potential.

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Objectives: To describe the prevalence, clinical characteristics and risk factors of liver steatosis and fibrosis in type 2 diabetes mellitus (T2DM) patients in eastern China.

Design: A cross-sectional, multicentre study based on an ongoing cohort study.

Setting: 16 clinics in eastern China, including primary clinics to tertiary hospitals.

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Biliary stricture can be induced by intrinsic narrowing and extrinsic compression, with the majority of cases being malignant. Clinically, distinguishing between benign and malignant biliary strictures remains a considerable challenge, and the ongoing disagreement over the optimal choice of biliary stents significantly influences treatment strategies and impacts patients' survival and prognosis. The utilization and advancement of endoscopic techniques have heightened the diagnostic sensitivity for biliary strictures.

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Sepsis-induced cardiomyopathy: understanding pathophysiology and clinical implications.

Arch Toxicol

November 2024

Emergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.

Sepsis is a life-threatening form of organ dysfunction resulting from a dysregulated response to infection. The complex pathogenesis of sepsis poses challenges because of the lack of reliable biomarkers for early identification and effective treatments. As sepsis progresses to severe forms, cardiac dysfunction becomes a major concern, often manifesting as ventricular dilation, a reduced ejection fraction, and a diminished contractile capacity, known as sepsis-induced cardiomyopathy (SIC).

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Blocking Na1.8 regulates atrial fibrillation inducibility and cardiac conduction after myocardial infarction.

BMC Cardiovasc Disord

October 2024

Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Disease, National Clinical Research Center for Interventional Medicine, Fudan University, Shanghai, 200032, China.

Background: The role of Na1.8 impacts in atrial fibrillation susceptibility after myocardial infarction remains only partially understood. We studied the effect of blocking Na1.

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Article Synopsis
  • Distal tibiofibular syndesmosis injuries commonly accompany ankle fractures in adults, often leading to specific avulsions named Tillaux, Wagstaffe, and Volkmann, with one being undefined.
  • A study analyzed imaging data from 1,770 ankle fracture patients to assess the incidence of these avulsion fractures over a 12-year period.
  • Results showed a total avulsion incidence of 26.3%, with the highest frequency being Volkmann fractures at 19.9%, followed by Tillaux (5.3%) and Wagstaffe (3.3%), while fibular avulsion of the PITFL was reported for the first time at 0.5%.
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Article Synopsis
  • Calcaneal body fractures can cause foot shortening, impacting function, making restoration of length important for recovery.
  • This study used finite element analysis to evaluate different internal fixation methods—distraction screw, lag screw, frame locking plate, and T-shaped locking plate—for treating Sanders type II calcaneal fractures under varying forces.
  • Results showed that the distraction screw minimized shortening and stress on the calcaneus compared to other methods, suggesting it may be the best option for preventing calcaneal shortening.
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Diagnostic Value of Serum Apolipoprotein B100 Combined With Hippocampal Volume in Alzheimer's Disease.

Brain Behav

October 2024

Department of Neurology, The Affiliated People's Hospital of, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.

Purpose: To explore the diagnostic value of serum apolipoprotein B100 (Apo B100) combined with hippocampal volume in Alzheimer's disease (AD).

Methods: A total of 59 AD patients and 59 healthy subjects were selected. The Mini-Mental State Examination (MMSE) was used for neuropsychological assessment.

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Objective: This study aimed to compare three objective nutritional screening tools for identifying GLIM-defined malnutrition in patients with gastric cancer (GC).

Method: Objective nutritional screening tools including geriatric nutritional risk index (GNRI), prognostic nutritional index (PNI), and controlling nutritional status (CONUT) score, were evaluated in patients with GC at our institution. Malnutrition was diagnosed according to the GLIM criteria.

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Comparison of Risk Factors Between Lean and Nonlean Metabolic Dysfunction-Associated Steatotic Liver Disease in Individuals With Type 2 Diabetes: A Multicenter Study.

Endocr Pract

December 2024

Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China; Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Southeast University, Nanjing, China; Institute of Glucose and Lipid Metabolism, Southeast University, Nanjing, China. Electronic address:

Article Synopsis
  • A multi-center study investigated liver conditions (steatosis and fibrosis) in patients with type 2 diabetes, specifically comparing lean individuals (BMI < 23 kg/m) to non-lean individuals (BMI ≥ 23 kg/m).
  • The study included 1,762 participants and discovered that lean patients experienced higher rates of liver steatosis (44.7%) and fibrosis (23.4%) along with more hypertension and cardiovascular issues.
  • Findings revealed that risk factors for liver steatosis vary significantly between lean and non-lean patients, suggesting the need for different management approaches based on body composition.
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Article Synopsis
  • The study investigates how positioning the endotracheal tube (ET) at the glottis through a laryngeal mask airway (LMA) can reduce ventilation issues caused by glottic contraction during surgery.
  • In a randomized trial, patients were divided into two groups: one using only the LMA and the other combining the LMA with the ET, showing significantly lower leakage rates in the latter group.
  • Results indicated that while the combination method reduced LMA leakage, it also maintained stable blood pressure and heart rate, with no significant increase in postoperative complications.
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Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis.

Redox Biol

October 2024

Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, China. Electronic address:

Background & Aims: Sarcopenia, a prevalent condition, significantly impacts the prognosis of patients with decompensated cirrhosis (DC). Serum fibroblast growth factor 21 (FGF21) levels are significantly higher in DC patients with sarcopenia. Satellite cells (SCs) play a role in aging- and cancer-induced sarcopenia.

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[Expression and Function of circ_0073585 in Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi

August 2024

Laboratory Center, The Affiliated People's Hospital of Jiangsu University, The Key Lab of Precision Diagnosis and Treatment of Zhenjiang City, Zhenjiang 212002, Jiangsu Province, China.

Objective: To investigate the expression level, clinical significance and function of circular RNAs (circRNAs) circ_0073585 in the bone marrow of patients with acute myeloid leukemia (AML).

Methods: The expression levels of circ_0073585 in bone marrow samples of 106 newly diagnosed AML patients and 38 controls were detected by real-time quantitative PCR (RQ-PCR). The differences were compared between the two groups and their clinical significance was analyzed.

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Colorectal Cancer (CRC) is the third most common cancer worldwide, and the occurrence and development of CRC are influenced by the molecular biology characteristics of CRC, especially alterations in key signaling pathways. The transforming growth factor-β (TGF-β) plays a crucial role in cellular growth, differentiation, migration, and apoptosis, with SMAD4 protein serving as a key transcription factor in the TGF-β signaling pathway, thus playing a significant role in the onset and progression of CRC. CRC is one of the malignancies with a high mortality rate worldwide.

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Article Synopsis
  • - The study focuses on analyzing antimicrobial resistance (AMR) genes in eight strains of non-typhoidal Salmonella (NTS) isolated from fecal samples of patients in Zhenjiang City, China, during 2022.
  • - The NTS Typhimurium ST19 was the most prevalent serotype, and the study identified several AMR genes, with AAC(6)-Iaa being the most common, along with various mobile genetic elements (MGEs) that help spread these resistance traits.
  • - The findings emphasize the importance of understanding genetic mechanisms of AMR in NTS to aid in preventing and controlling antibiotic resistance related to food-borne illnesses.
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CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation.

Drug Resist Updat

November 2024

Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical University, Nanjing 210029, China. Electronic address:

Aims: As our comprehension of the intricate relationship between cellular senescence and tumor biology continues to evolve, the therapeutic potential of cellular senescence is gaining increasing recognition. Here, we identify chromobox 4 (CBX4), a Small Ubiquitin-related Modifier (SUMO) E3 ligase, as an antagonist of cellular senescence and elucidate a novel mechanism by which CBX4 promotes drug resistance and malignant progression of gastric cancer (GC).

Methods: In vitro and in vivo models were conducted to investigate the manifestation and impact of CBX4 on cellular senescence and chemoresistance.

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Article Synopsis
  • - Immune checkpoint inhibitors (ICIs) have revolutionized tumor treatment by offering high specificity and low side effects, particularly targeting the PD-1/PD-L1 axis which plays a crucial role in how tumors evade the immune system
  • - Understanding the regulatory factors affecting the PD-1/PD-L1 axis is essential for enhancing the effectiveness of ICIs and improving patient outcomes in cancer therapy
  • - Non-coding RNAs (ncRNAs) have been shown to influence PD-L1 expression in the tumor immune microenvironment, thereby affecting the success of ICI therapies and highlighting their potential as targets for more effective cancer treatments
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Article Synopsis
  • The study investigates malignant biliary stricture (MBS) and aims to identify risk factors for malignancy in patients diagnosed through ERCP.
  • It utilizes a retrospective analysis of 398 patients, employing machine learning techniques to develop a predictive model that enhances diagnostic accuracy.
  • The most effective model (RF model) achieved an AUROC of 0.988, pinpointing specific risk factors such as age, stricture location, and certain biomarkers, thereby aiding in better clinical decision-making and patient outcomes.
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Research Progress on Mechanisms and Treatment of Sepsis-Induced Myocardial Dysfunction.

Int J Gen Med

August 2024

Division of Cardiology, Department of Medicine, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.

Sepsis is a syndrome of organ dysfunction caused by a dysregulated immune response to infection, with high morbidity and mortality. At present, there have been many advances in the study of its pathogenesis, especially the cardiac dysfunction caused by sepsis, namely sepsis-induced myocardial dysfunction, SIMD, which has received widespread attention. The mechanisms of SIMD mainly include excessive release of inflammatory mediators, impaired mitochondrial function, autophagy, apoptosis and myocardial dysfunction.

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