Efficacy and safety of quetiapine extended release monotherapy in bipolar depression: a multi-center, randomized, double-blind, placebo-controlled trial.

Rationale: Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder.

Objectives: The study evaluated the efficacy and safety of short-term quetiapine XR monotherapy in the treatment of depressive episodes of bipolar I and II disorders.

[Influence of co-culturing vascular endothelial cells and adipose-derived stromal cells on osteogenic differentiation in vitro].

Objective: To further study the influence of the co-cultivation of vascular endothelial cells (VECs) and adipose-derived stromal cells (ADSCs) on cell osteogenic differentiation in vitro and provide experimental evidences of the probability of the co-cultivation of VECs and ADSCs as the seed cells of tissue engineering.

Methods: The VECs derived from cord blood and ADSCs were prepared by full-term pregnancy SD rats and 18-week-old SD rats, to carry on the morphological observation and immunohistochemical staining identification. The third generation of ADSCs and the VECs induced by conditioned medium for 6 weeks were cultured and were divided into groups A, B, and C as the experimental group according to cell ratios of 3 : 1, 1 : 1, and 1 : 3, respectively.