The gene environment aetiology of freezing and its relationship with internalizing symptoms during adolescence.

Background: The freezing response is a universal response to threat, linked to attentive immobility and action preparation. It is relevant for acute stress coping in animals and humans, and subtle deviations in toddler freezing duration (absence of, or excessively long reactions) have been linked to higher risk for internalizing symptoms in adolescence. Yet, while individual freezing tendencies are relatively stable throughout life, little is known about their gene-environment aetiology.

Highly emissive polymorphs of anhydrous cadmium tetracyanoplatinate and their solvated coordination networks.

Two anhydrous polymorphs of cadmium cyanoplatinate Cd[Pt(CN)] coordination polymers have been synthesized and thermally, spectroscopically, and structurally characterized. α-Cd[Pt(CN)] and β-Cd[Pt(CN)] are densely packed, highly emissive 3-D solids, with quantum yields of 0.85 ( = 520 nm) and 0.

The pentacyclic triterpenoid phytosterol lupeol promotes antioxidant response in the nematode .

Plants of the Mimosa genus are studied and used for their bioactive properties. Among bioactive phytochemicals are quercetin and myricetin, which have been demonstrated to act as antioxidants in many contexts (Taheri et al. 2020; Xu et al.

Combining multilayered wrinkled polymer SERS substrates and spectral data processing for low concentration analyte detection.

A series of thermally shrinkable polymer surface-enhanced Raman scattering (SERS) substrates were prepared with bimetallic Au and Ag (oxidized or not) films and with Au nanoparticles (AuNPs) located at different places in the layered structure to evaluate the synergistic effect of different known SERS amplification methods to enhance the Raman signal for low concentration dopamine detection. A bimetallic Au and Ag layered structure improved the Raman signal by 5 and 2 times compared to the single-layered Au and Ag films. Oxidizing the Ag layer prior to deposition of Au further improved the signal by a factor of 2, while adding AuNP on wrinkled films increased another 10 times the intensity of the Raman signal.

Counting Salem Numbers of Arithmetic Hyperbolic 3-Orbifolds.

It is known that the lengths of closed geodesics of an arithmetic hyperbolic orbifold are related to Salem numbers. We initiate a quantitative study of this phenomenon. We show that any non-compact arithmetic 3-dimensional orbifold defines square-rootable Salem numbers of degree 4 which are less than or equal to .

Relationship between environmental pollution and economic development in late-developing regions shows an inverted V.

In late-developing regions, new technologies and previous experiences are applied to reduce the impact of economic development on environmental pollution in the early stages. After economic development has reached a certain level, the application of new environmental remediation technologies and methods can accelerate environmental restoration. Therefore, we hypothesized that the relationship between economic development and environmental pollution would exhibit an inverted V in late-developing regions.

Simulation of atrial fibrillation in a non-ohmic propagation model with dynamic gap junctions.

Gap junctions exhibit nonlinear electrical properties that have been hypothesized to be relevant to arrhythmogenicity in a structurally remodeled tissue. Large-scale implementation of gap junction dynamics in 3D propagation models remains challenging. We aim to quantify the impact of nonlinear diffusion during episodes of arrhythmias simulated in a left atrial model.

Pharmacist-led interventions during transitions of care of older adults admitted to short term geriatric units: Current practices and perceived barriers.

Background: During transitions of care, older adults are at risk of adverse drug events which could lead to avoidable hospital visits. Pharmacists are increasingly involved in care teams at various stages of the continuum of care. The types and frequency of clinical interventions performed by pharmacists in the geriatric practice setting remain poorly documented.

The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers.

Sortilin (SORT1) receptor-mediated endocytosis functions were exploited for this new approach for effective and safe treatments of gynecological cancers. Here, high expression of SORT1 was found in >75% of the clinically annotated ovarian and endometrial tumors analyzed by immunohistochemistry. Therefore, the anticancer properties of the peptide-drug conjugate TH1902, a peptide that targets SORT1 and which is linked to docetaxel molecules, were investigated both in vitro using ovarian and endometrial cancer cell cultures and in vivo using xenograft models.

Pet ownership and psychological well-being during the COVID-19 pandemic.

The question of pet ownership contributing to human well-being has received mixed empirical evidence. This contrasts with the lay intuition that pet ownership contributes positively to wellness. In a large representative sample, we investigate the differences that may exist between pet vs.

Structuring and organizing interprofessional healthcare in partnership with patients with diabetes: the INterprofessional Management and Education in Diabetes care (INMED) pathway.

Type 2 diabetes is a complex chronic disease that requires ongoing monitoring by an interprofessional team to prevent complications. The INMED (INterprofessional Management and Education in Diabetes) care pathway was developed by our team to optimize primary care services for these patients and their families. The objective of this study is to describe the preliminary results of its adoption and implementation.

Competencies for Physiotherapists Working to Facilitate Rehabilitation, Work Participation and Return to Work for Workers with Musculoskeletal Disorders: A Scoping Review.

Purpose The aim of this scoping review was to synthesize the literature addressing the competencies that physiotherapists in a clinical setting need to facilitate the rehabilitation, work participation, and return to work of workers with musculoskeletal disorders.Methods We conducted a scoping review in accordance with Arksey & O'Malley's five-step method. The following categories of keywords were used during searches in Embase, Medline and CINAHL in May 2020: (1) physiotherapy/physical therapy; (2) return to work, work participation or occupational health; and (3) education/professional competencies/guidelines.

The process of learning the autogenic training relaxation technique and its benefits on the wellness of people living with HIV.

Background: Various mind-body practices are used by people living with HIV to promote their general well-being. Among these is autogenic training (AT), a self-guided relaxation technique requiring regular practice for observable benefits. However, little has been written about the process of learning this technique, which is obviously a prerequisite to regular practice.

Red Absorbing Cyclometalated Ir(III) Diimine Photosensitizers Competent for Hydrogen Photocatalysis.

Two new cyclometalated Ir(III) diimine complexes were used as photosensitizers for homogeneous hydrogen evolution reaction (HER). These complexes were characterized by electrochemistry, ultraviolet-visible absorption, time-resolved and steady-state photoluminescence spectroscopy as well as by theoretical methods. The metal-ligand-to-ligand charge transfer character of their lowest excited state was shown to be competent for efficient H photoproduction in the presence of [Co(dmgH)(py)Cl] as the hydrogen evolution catalyst, triethanolamine as the sacrificial electron donor, and HBF as the proton source.

Practical non-enzymatic synthesis of propargyl sialyl-α-(2-3')-lactosamine trisaccharide using minimal protecting groups manipulation.

The trisaccharide, prop-2-ynyl 5-acetamido-3,5-dideoxy-d-glycero-α-d-galacto-2-nonulopyranosylonic acid-(2 → 3)-β-d-galactopyranosyl-(1 → 4)-2-acetamido-2-deoxy-β-d-glucopyranoside (9) has been efficiently synthesized in a few steps without the need of conformationally constrained glycosyl donors and acceptors or enzymes. First, using the known prop-2-ynyl 2-acetamido-2-deoxy-6-O-tert-butyldiphenylsilyl-β-d-glucopyranoside as acceptor (2) and the peracetylated galactosyl trichloroacetimidate (3) as glycosyl donor, followed by protecting groups manipulation, prop-2-ynyl (6-O-tert-butyldiphenylsilyl-β-d-galactopyranosyl)-(1 → 4)-2-acetamido-2-deoxy-6-O-tert-butyldiphenylsilyl-β-d-glucopyranoside (6) was synthesized with exclusive O-4 regioselectivity due to steric hindrance of the upper face of the acceptor at O-3. Sialylation with the thiophenyl glycosyl donor (7) afforded the desired trisaccharide with the shortest number of steps and in higher overall yield than previously reported methodologies.

Grazer-mediated regeneration of methylmercury, inorganic mercury, and other metals in freshwater.

Whereas it is well established that zooplankton can transfer various pollutants such as mercury (Hg) from primary producers to higher trophic levels, less is known on the effects of their activities on the recycling of Hg in aquatic ecosystems. Here, the impact of zooplankton grazing efficiency and excretion/egestion processes on metal concentrations in freshwater was investigated. Isotopically labeled algae (HgCl, MeHgCl) was used as a food source and the transfer of the selected isotopes to the culture medium during grazing was measured.

A pragmatic randomized controlled trial of a group self-management support program versus treatment-as-usual for anxiety disorders: study protocol.

Background: The integration of a personal recovery-oriented practice in mental health services is an emerging principle in policy planning. Self-management support (SMS) is an intervention promoting recovery that aims at educating patients on the nature of their mental disorder, improving their strategies to manage their day-to-day symptoms, fostering self-efficacy and empowerment, preventing relapse, and promoting well-being. While SMS is well established for chronic physical conditions, there is a lack of evidence to support the implementation of structured SMS programs for common mental disorders, and particularly for anxiety disorders.

Evaluation of uptake of the cytostatic methotrexate in Elliptio complanata mussels by LC-MS/MS.

Aquatic organisms are continuously exposed to emerging contaminants coming from urban effluents of wastewater treatment plants. The contamination of surface water by those effluents poses a number of environmental risks, and pharmaceuticals are part of this class of effluent contaminants. Various classes of pharmaceuticals are not treated by wastewater treatment plants and anticancer drugs are part of them.

Do stop-signs improve the safety for all road users? A before-after study of stop-controlled intersections using video-based trajectories and surrogate measures of safety.

Converting minor-approach-only stop (MAS) intersections to all-way-stop (AWS) intersections is a prevailing safety countermeasure in North American urban areas. Although the general population positively perceives the installation of stop-signs in residential areas, little research has investigated the impact of AWS on road safety and road user behaviour. This paper investigated the safety effectiveness of converting MAS to AWS intersections using an observational before and after approach and surrogate measures of safety.

Live-cell Imaging and Analysis of Germline Stem Cell Mitosis in .

Model organisms offer the opportunity to decipher the dynamic and complex behavior of stem cells in their native environment; however, imaging stem cells remains technically challenging. germline stem cells (GSCs) are distinctly accessible for live imaging but relatively few studies have taken advantage of this potential. Here we provide our protocol for mounting and live imaging dividing GSCs, as well as analysis tools to facilitate the processing of large datasets.

Pathways for cross-boundary effects of biodiversity on ecosystem functioning.

The biodiversity-ecosystem functioning concept asserts that processes in ecosystems are markedly influenced by species richness and other facets of biodiversity. However, biodiversity-ecosystem functioning studies have been largely restricted to single ecosystems, ignoring the importance of functional links - such as the exchange of matter, energy, and organisms - between coupled ecosystems. Here we present a basic concept and outline three pathways of cross-boundary biodiversity effects on ecosystem processes and propose an agenda to assess such effects, focusing on terrestrial-aquatic linkages to illustrate the case.

Biogenic Sulfur-Based Chalcogenide Nanocrystals: Methods of Fabrication, Mechanistic Aspects, and Bio-Applications.

Bio-nanotechnology has emerged as an efficient and competitive methodology for the production of added-value nanomaterials (NMs). This review article gathers knowledge gleaned from the literature regarding the biosynthesis of sulfur-based chalcogenide nanoparticles (S-NPs), such as CdS, ZnS and PbS NPs, using various biological resources, namely bacteria, fungi including yeast, algae, plant extracts, single biomolecules, and viruses. In addition, this work sheds light onto the hypothetical mechanistic aspects, and discusses the impact of varying the experimental parameters, such as the employed bio-entity, time, pH, and biomass concentration, on the obtained S-NPs and, consequently, on their properties.

From Surface to Subsurface: Diversity, Composition, and Abundance of Sessile and Endolithic Bacterial, Archaeal, and Eukaryotic Communities in Sand, Clay and Rock Substrates in the Laurentians (Quebec, Canada).

Microbial communities play an important role in shallow terrestrial subsurface ecosystems. Most studies of this habitat have focused on planktonic communities that are found in the groundwater of aquifer systems and only target specific microbial groups. Therefore, a systematic understanding of the processes that govern the assembly of endolithic and sessile communities is still missing.