Massive GNSS data for road safety analysis: Comparing crash models for several Canadian cities and data sources.

Mobile sensors are a useful data source with applications in several transportation fields. Though cost of collection, transmission, and storage has limited studies on driving data and safety, this can be overcome through usage-based insurance (UBI). In UBI programs, drivers are monitored, and their premiums are adjusted based on driver-level surrogate safety measures (SSMs) related to exposure and driving style.

The relationship between dietary exposure to persistent organic pollutants from fish consumption and type 2 diabetes among First Nations in Canada.

Objective: We previously examined the associations between dietary dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyls (PCBs) intake from fish consumption and type 2 diabetes (T2D) prevalence in Ontario and Manitoba. This study aims to further explore the relationship in a regionally representative sample of First Nations adults living on-reserve across Canada.

Methods: Dietary, health and lifestyle data collected by the cross-sectional First Nations Food, Nutrition and Environment Study (2008-2018) were analyzed.

Associations of health status and diabetes among First Nations Peoples living on-reserve in Canada.

Objective: Our objective is to describe self-reported health status, prevalence of diabetes and obesity and their associations in participants from the First Nations Food, Nutrition and Environment Study (FNFNES) in order to identify possible correlates of health in First Nations adults.

Methods: FNFNES is a participatory study with First Nations Peoples living on reserve lands south of the 60 parallel. Health and diabetes were self-reported, and prevalence of obesity was evaluated.

Pharmaceuticals in source waters of 95 First Nations in Canada.

Objectives: Pharmaceuticals are emerging contaminants in the environment. Little has been published about the presence of pharmaceuticals in waterbodies nearby or on reserve land of First Nations in Canada. The objectives of this study were to (1) quantify the level of pharmaceuticals in First Nations' surface waters, (2) calculate the human health risks of the mixtures found, and (3) measure the exposure to pharmaceuticals in First Nations' drinking water where source water was highly contaminated.

Metals in the drinking water of First Nations across Canada.

Objectives: The First Nations Food, Nutrition and Environment Study (FNFNES), a community-based participatory research project, measured the levels of metals of health concern and the levels of metals that have operational guidance (OG) and aesthetic objectives (AO) in drinking water of First Nations (FN) south of the 60 parallel.

Methods: Both stagnant (first draw) and flushed tap water samples were collected from participating households in 91 FN representing 11 ecozones. The concentrations of metals were quantified and compared to Health Canada's Guidelines for Canadian Drinking Water Quality (GCDWQ).

Regionally representative hair mercury levels in Canadian First Nations adults living on reserves.

Objective: The primary objective of this participatory study was to assess the current body burden of mercury among First Nations adults.

Methods: The First Nations Food, Nutrition and Environment Study (2008-2018) collected regionally representative data from First Nations adults living on reserves south of the 60 parallel. Mercury was analyzed in hair as a preferred biomarker for prolonged exposure.

Levels of metals and persistent organic pollutants in traditional foods consumed by First Nations living on-reserve in Canada.

Objectives: First Nations may have a higher risk of contaminant exposure from the consumption of traditional foods. The objective of this study was to measure concentrations of metals and organochlorines in traditional foods commonly consumed by First Nations in Canada and estimate the risk from dietary exposure.

Methods: Data were collected from the participatory First Nations Food, Nutrition and Environment Study (2008-2018).

Importance of fish for food and nutrition security among First Nations in Canada.

Objective: To investigate the relationships between fish/seafood consumption patterns and food security status among First Nations (FN) communities in Canada. We estimated the contribution of fish/seafood to daily nutrient requirements. Barriers to traditional food (TF) access including fish were summarized.

First Nations households living on-reserve experience food insecurity: prevalence and predictors among ninety-two First Nations communities across Canada.

Objective: To describe the prevalence of food insecurity in First Nations households across Canada while identifying barriers and enablers to traditional food (TF) consumption.

Methods: The First Nations Food, Nutrition and Environment Study is a cross-Canada participatory study of on-reserve First Nations from 2008 to 2018. The Household Food Security Survey Module was used to capture income-related challenges experienced by First Nations households.

Comparison of measures of diet quality using 24-hour recall data of First Nations adults living on reserves in Canada.

Objective: Assess the diet quality of First Nations adults in Canada using percentage energy from traditional foods (TF) and ultra-processed products (UPP), food portions from the 2007 Eating Well with Canada's Food Guide - First Nations, Inuit and Métis (EWCFG-FNIM) and a Healthy Eating Index (HEI).

Methods: Data collection for this participatory research occurred in 92 First Nations reserves across Canada from 2008 to 2016. Percent daily energy intakes were estimated from 24-hour recalls for TF and NOVA food categories.

Nutrient adequacy and nutrient sources of adults among ninety-two First Nations communities across Canada.

Objectives: To identify food sources of nutrients in First Nations adults in Canada and to establish whether these populations are meeting their nutrient requirements and whether traditional foods (TF) contribute to better nutrient intake.

Methods: The First Nations Food, Nutrition and Environment Study is a cross-Canada participatory study of First Nations adults living south of the 60 parallel. Twenty-four-hour recalls were conducted in 92 First Nations communities from 2008 to 2016.

Importance of the traditional food systems for First Nations adults living on reserves in Canada.

Objective: To describe the traditional food (TF) systems of First Nations in Canada, including intake, barriers and promoters.

Methods: The First Nations Food, Nutrition and Environment Study is a cross-Canada participatory study of First Nations adults below the 60 parallel that obtained data for communities excluded from other national studies. A food frequency questionnaire was used to establish frequency of TF intake (number of days in a year) to allow comparisons across ecozones/regions in Canada.

The First Nations Food, Nutrition and Environment Study (2008-2018)-rationale, design, methods and lessons learned.

Objective: To describe the rationale, the participatory nature of the methodology, and the lessons learned during the First Nations Food, Nutrition and Environment Study (FNFNES), a community-based participatory research project implemented in eight Assembly of First Nations regions, which includes the entirety of Canada south of the 60 parallel.

Methods: FNFNES respected the First Nations principles of Ownership, Control, Access and Possession (OCAP®) ( https://fnigc.ca/ocap ).

Mixtures of rare earth elements show antagonistic interactions in Chlamydomonas reinhardtii.

In order to better understand the environmental risks of the rare earth elements (REEs), it is necessary to determine their fate and biological effects under environmentally relevant conditions (e.g. at low concentrations, REE mixtures).

Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.

The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been reported in a wide range of cancers. Inhibition of TEAD represses the expression of associated genes, demonstrating the value of this transcription factor for the development of novel anti-cancer therapies.

Synthesis of NVS-BPTF-1 and evaluation of its biological activity.

BPTF (bromodomain and PHD finger containing transcription factor) is a multidomain protein that plays essential roles in transcriptional regulation, T-cell homeostasis and stem cell pluripotency. As part of the chromatin remodeling complex hNURF (nucleosome remodeling factor), BPTF epigenetic reader subunits are particularly important for BPTF cellular function. Here we report the synthesis of NVS-BPTF-1, a previously reported highly potent and selective BPTF-bromodomain inhibitor.

Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides.

Background And Aims: Anastomotic leak (AL) is a major complication in colorectal surgery. Recent evidence suggests that the gut microbiota may affect healing and may cause or prevent AL. Butyrate is a beneficial short-chain fatty acid (SCFA) that is produced as a result of bacterial fermentation of dietary oligosaccharides and has been described as beneficial in the maintenance of colonic health.

Object expectations alter information use during visual recognition.

Prior expectations influence how we perceive and recognize objects. However, how they do so remains unclear, especially in the case of real-world complex objects. Expectations of objects may affect which features are used to recognize them subsequently.

Is the Cyanobacterial Bloom Composition Shifting Due to Climate Forcing or Nutrient Changes? Example of a Shallow Eutrophic Reservoir.

Cyanobacterial blooms in eutrophic freshwater is a global threat to the functioning of ecosystems, human health and the economy. Parties responsible for the ecosystems and human health increasingly demand reliable predictions of cyanobacterial development to support necessary decisions. Long-term data series help with identifying environmental drivers of cyanobacterial developments in the context of climatic and anthropogenic pressure.

Cardiopulmonary values and organ blood flows before and during heat stress: data in nine subjects at rest in the upright position.

Physiological changes associated with thermoregulation can influence the kinetics of chemicals in the human body such as alveolar ventilation (VA) and redistribution of blood flow to organs. In this study, the influence of heat stress on various physiological parameters was evaluated in nine male volunteers during sessions of exposure to wet-bulb globe temperatures (WBGT) of 21, 25, and 30 °C for 4 h. Skin and core temperatures and more than 20 cardiopulmonary parameters were measured.

Postural organization and inter-limb coordination are altered after stroke when an isometric maximum bilateral pushing effort of the upper limbs is performed.

Background: Postural strategies of the trunk and the lower limbs are linked to upper limb motor activities. The objective was to analyze the postural organization at the lower limbs as well as the inter-limb coordination during isometric maximal bilateral pushing of upper limbs.

Methods: Fifteen individuals after stroke and 17 healthy participants were assessed with an instrumented exerciser paired with an instrumented sitting surface while they executed isometric bilateral pushes with the upper limbs.

Evaluating the content of a patient-reported outcome measure for people with multimorbidity: a Delphi consensus.

Purpose: Evidence supporting multimorbidity-adapted interventions is scarce, mostly due to a lack of adapted outcome measures. Measurement constructs for a novel patient-reported outcome measure (PROM) were defined in previous studies using a literature review, a qualitative description from stakeholders, and an item pool identification process. The aim of this study was to attain consensus on the content of this novel PROM.

The harmful-dysfunction account of disorder, individual versus social values, and the interpersonal variability of harm challenge.

This paper presents the interpersonal variability of harm challenge to Jerome Wakefield's harmful-dysfunction account (HDA) of disorder. This challenge stems from the seeming fact that what promotes well-being or is harmful to someone varies much more across individuals than what is intuitively healthy or disordered. This makes it at least prima facie difficult to see how judgments about health and disorder could, as harm-requiring accounts of disorder like the HDA maintain, be based on, or closely linked to, judgments about well-being and harm.

Design, Synthetic Strategies, and Therapeutic Applications of Heterofunctional Glycodendrimers.

Glycodendrimers have attracted considerable interest in the field of dendrimer sciences owing to their plethora of implications in biomedical applications. This is primarily due to the fact that cell surfaces expose a wide range of highly diversified glycan architectures varying by the nature of the sugars, their number, and their natural multiantennary structures. This particular situation has led to cancer cell metastasis, pathogen recognition and adhesion, and immune cell communications that are implicated in vaccine development.