Trends in conductive MOFs for sensing: A review.

Metal-organic frameworks (MOFs) are porous, ordered arrays formed by coordination bonds between organic ligands and metal ions or clusters. The highly tunable properties of the MOF structure and performance make it possible to meet the needs of many applications. Conductive MOFs are essential in the domain of sensing due to their electrical conductivity, porosity, and catalytic properties, offering an effective platform for detection.

Influence of Body Mass Index on the Clinicopathological Features of Papillary Thyroid Carcinoma in a Chinese Population.

Previous studies suggested a relationship between obesity and a high risk of thyroid cancer. However, the association between high body mass index (BMI) and the aggressiveness of papillary thyroid carcinoma (PTC) is controversial. In this study, we aimed to investigate the impact of excess BMI on histopathologic aggressiveness of PTC in a Chinese population.

Targeting WDR5/ATAD2 signaling by the CK2/Ikaros axis demonstrates therapeutic efficacy in T-ALL.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a poor prognosis and limited options for targeted therapies. Identifying new molecular targets to develop novel therapeutic strategies is the pressing immediate issue in T-ALL. Here, we observed high expression of WD Repeat-Containing Protein 5 (WDR5) in T-ALL; with in vitro and in vivo models we demonstrated the oncogenic role of WDR5 in T-ALL by activating cell cycle signaling through its new downstream effector, ATPase family AAA domain-containing 2 (ATAD2).

Structural Design and Challenges of Micron-Scale Silicon-Based Lithium-ion Batteries.

Currently, lithium-ion batteries (LIBs) are at the forefront of energy storage technologies. Silicon-based anodes, with their high capacity and low cost, present a promising alternative to traditional graphite anodes in LIBs, offering the potential for substantial improvements in energy density. However, the significant volumetric changes that silicon-based anodes undergo during charge and discharge cycles can lead to structural degradation.

Unveiling the Racemization in Ferroelectrics with Coupled Ferroelectricity and Optical Activity.

The most distinctive features of ferroelectrics are spontaneous polarization and depolarization. Ferroelectricity was first observed in Rochelle salt, a compound with a chiral component in which the molecular chirality is not affected by depolarization. For structurally chiral ferroelectrics (SCFs), such as triglycine sulfate, which lacks chiral components, the depolarization effect on chirality presents an intriguing and unexplored topic.

Multiparametric MRI for Assessment of the Biological Invasiveness and Prognosis of Pancreatic Ductal Adenocarcinoma in the Era of Artificial Intelligence.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest malignant tumor, with a grim 5-year overall survival rate of about 12%. As its incidence and mortality rates rise, it is likely to become the second-leading cause of cancer-related death. The radiological assessment determined the stage and management of PDAC.

The effect of early intravenous amino acid supplementation in critically ill patients without acute kidney injury: Protocol for a multicentre, randomised, parallel-controlled trial (the ESSENTIAL trial).

Objective: There is uncertainty about whether early infusion of intravenous amino acids confers clinical benefits in critically ill patients. In this study, we aimed to test the hypothesis that intravenous amino acids could improve 90-day mortality in critically ill patients with normal kidney function.

Design: This is a multicentre, open-label, randomised, parallel-controlled trial.

PAXIP1 is regulated by NRF1 and is a prognosis‑related biomarker in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is characterized by a poor prognosis globally. PAX-interacting protein 1 (PAXIP1) serves a key role in the development of numerous human cancer types. Nevertheless, its specific involvement in HCC remains poorly understood.

[Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data].

As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity.

Dynamic Changes and Trends of SARS-CoV-2 Antibodies Induced by Infection and Vaccination Across Multiple Time Points.

As the COVID-19 pandemic continues, increasingly complex vaccination and infection histories have made it urgent to investigate the antibody dynamics in populations with hybrid immunity. This study aimed to explore the multi-time-point dynamics of SARS-CoV-2 IgG antibody levels in a community-based population in Jiangsu Province, China, following the Omicron BA.5 wave, as well as the long-term persistence of IgG antibodies nearly 2 years postinfection.

Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis.

Background: Skeletal muscle injury caused by excessive exercise is one of the most commonly seen clinical diseases. It is indispensable to explore drugs for treating and relieving skeletal muscle injury. Gallic acid (GA) is a polyphenolic extract that has anti-inflammatory and antioxidant biological activities.

The gut-brain axis underlying hepatic encephalopathy in liver cirrhosis.

Up to 50-70% of patients with liver cirrhosis develop hepatic encephalopathy (HE), which is closely related to gut microbiota dysbiosis, with an unclear mechanism. Here, by constructing gut-brain modules to assess bacterial neurotoxins from metagenomic datasets, we found that phenylalanine decarboxylase (PDC) genes, mainly from Ruminococcus gnavus, increased approximately tenfold in patients with cirrhosis and higher in patients with HE. Cirrhotic, not healthy, mice colonized with R.

Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway.

Silibinin (Sil) is a major bioactive component of silymarin, extracted from the fruit and seeds of Silybum marianum. Silibinin meglumine (SM) is a water-soluble derivative of silibinin that has shown significant potential in liver fibrosis. However, the potential effects and underlying mechanisms of SM on acute liver failure (ALF) are still not fully understood.

Mechanism of Traditional Chinese Medicine extract in the treatment of diabetic erectile dysfunction.

Ethnopharmacological Relevance: Diabetic erectile dysfunction (DED) is a prevalent but often overlooked microvascular complication of type 2 diabetes mellitus (T2DM), with strong associations to cardiovascular disease. The pathophysiology of erectile dysfunction (ED) in T2DM patients is more intricate than in non-diabetic individuals, likely involving multiple pathogenic mechanisms such as endothelial dysfunction, vascular alterations, neuropathy, and oxidative stress. Traditional Chinese Medicine (TCM) has long been utilized in the management of DED, drawing on an extensive body of clinical experience.

Automated gradation design of natural waste gravel soil stabilized by composite soil stabilizer based on a novel DNNSS-APDM-PFC model.

The utilization of natural waste gravel soil as base course material contributes to environmental protection and carbon emission reduction. The purpose of this research is to establish a new model for automated gradation design of the composite soil stabilizer-stabilized waste gravel soil (CSSWGS). A gradation range of CSSWGS has been proposed.

An Amorphous Donor-Acceptor Conjugated Polymer with Both High Charge Carrier Mobility and Luminescence Quantum Efficiency.

Organic semiconducting polymers play a pivotal role in the development of field-effect transistors (OFETs) and organic light-emitting diodes (OLEDs), owing to their cost-effectiveness, structural versatility, and solution processability. However, achieving polymers with both high charge carrier mobility (μ) and photoluminescence (PL) quantum yield (Φ) remains a challenge. In this work, we present the design and synthesis of a novel donor-acceptor π-conjugated polymer, TTIF-BT, featuring a di-Thioeno[3,2-b] ThioenoIndeno[1,2-b] Fluorene (TTIF) backbone as the donor component.

Research Progress on the Posterior Midline Lumbar Spinous Process-Splitting Approach.

The traditional posterior median approach laminectomy is widely used for lumbar decompression. However, the bilateral dissection of paraspinal muscles during this procedure often leads to postoperative muscle atrophy, chronic low back pain, and other complications. The posterior midline spinous process-splitting approach (SPSA) offers a significant advantage over the traditional approach by minimizing damage to the paraspinal muscles.

Molecular Ferroelectrics for Highly Sensitive Detection Toward Low-Frequency Sound Recognition.

Human hearing cannot sensitively detect sounds below 100 Hz, which can affect the physical well-being and lead to dizziness, headaches, and nausea. Piezoelectric acoustic sensors still lack sensitivity to low-frequency sounds owing to the low piezoelectric coefficient or high elastic modulus of materials. The low elastic modulus and substantial piezoelectric coefficient of molecular ferroelectric materials make them excellent candidates for acoustic sensors.

Economic Value of Informal Care: Contingent Valuation From the Perspective of Caregivers and Care Recipients in China.

We estimated the monetary value of informal care from the perspectives of informal caregivers and care recipients in China using the contingent valuation method. Data were obtained from a specially designed survey of 1458 informal caregivers and 972 care recipients. The mean for caregivers' willingness to pay (WTP) for reducing informal care by 1 h per week was CNY32.

Demand, utilization, and supply of community smart senior care services for older people in China.

Objective: Although smart senior care services offer numerous benefits, they have not yet gained widespread acceptance among the general populace, particularly seniors. Numerous related issues have surfaced, with the structural imbalance between supply and demand being most prominent. Currently, there is a lack of research distinguishing between the various categories of demand for smart ageing services and the associated behaviors of older individuals.

Developing 3D bioprinting for organs-on-chips.

Organs-on-chips (OoCs) have significantly advanced biomedical research by precisely reconstructing human microphysiological systems with biomimetic functions. However, achieving greater structural complexity of cell cultures on-chip for enhanced biological mimicry remains a challenge. To overcome these challenges, 3D bioprinting techniques can be used in directly building complex 3D cultures on chips, facilitating the engineering of organ-level models.

Burden of chronic obstructive pulmonary disease in adults aged 70 years and older, 1990-2021: Findings from the Global Burden of Disease Study 2021.

Background: Life expectancy at age 70 has continued to rise globally over the past 30 years. However, a comprehensive assessment of the burden of COPD in older adults is lacking. We aimed to estimate the burden of COPD and its attributable risk factors among adults aged ≥70 years.

Comparative transcriptome analyses of different orthosiphon aristatus tissues reveal differentially expressed genes associated with flavonoid biosynthesis.

Orthosiphon aristatus (O. aristatus) has been used as a popular traditional folk medicine for the treatment of kidney disease. Recent studies have shown that O.