9 results match your criteria: "sebastien.bouret@icm-institute.org.[Affiliation]"

Locus Coeruleus, Noradrenaline, and Behavior: Network Effect, Network Effects?

Neuron

August 2019

Team Motivation Brain & Behavior, ICM - Institut du Cerveau et de la Moelle épinière, CNRS UMR 7225 - INSERM U1127 - UPMC UMR S 1127, Hôpital Pitié-Salpêtrière, 47, Boulevard de l'Hôpital, 75013 Paris, France. Electronic address:

How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition?

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Refining the ecological brain: Strong relation between the ventromedial prefrontal cortex and feeding ecology in five primate species.

Cortex

September 2019

Team Motivation Brain & Behavior, ICM - Institut du Cerveau et de la Moelle épinière, CNRS UMR 7225 - INSERM U1127 - UPMC UMR S 1127, Hôpital Pitié-Salpêtrière, Paris, France. Electronic address:

Article Synopsis
  • Primates depend on cognitive skills like decision-making and episodic memory to navigate complex environments and effectively forage for food.
  • The study focuses on the ventromedial prefrontal cortex (VMPFC), suggesting it plays a crucial role in foraging and cognitive functions related to feeding ecology.
  • Findings indicate that the size of the VMPFC is significantly associated with dietary diversity and complexity in foraging strategies across various primate species.
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What Is the Relationship between Dopamine and Effort?

Trends Neurosci

February 2019

Institut du Cerveau et de la Moelle Épinière (ICM), Centre National de la Recherche Scientifique (CNRS), Hôpital Pitié Salpêtrière, 75013 Paris, France. Electronic address:

The trade-off between reward and effort is at the heart of most behavioral theories, from ecology to economics. Compared to reward, however, effort remains poorly understood, both at the behavioral and neurophysiological levels. This is important because unwillingness to overcome effort to gain reward is a common feature of many neuropsychiatric and neurological disorders.

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Correction to: Dual contributions of noradrenaline to behavioural flexibility and motivation.

Psychopharmacology (Berl)

October 2018

Motivation, Brain and Behavior Team, Institut du Cerveau et de la Moelle Epinière, CNRS UMR 7225 - INSERM U1127 - UPMC UMR S 1127, Hôpital Pitié-Salpétrière, 47, Boulevard de l'Hôpital, 75013, Paris, France.

The article Dual contributions of noradrenaline to behavioural flexibility and motivation written by Caroline I. Jahn, Sophie Gilardeau, Chiara Varazzani, Bastien Blain, Jerome Sallet, Mark E. Walton, Sebastien Bouret was originally published electronically on the publisher's internet portal.

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Dual contributions of noradrenaline to behavioural flexibility and motivation.

Psychopharmacology (Berl)

September 2018

Motivation, Brain and Behavior Team, Institut du Cerveau et de la Moelle Epinière, CNRS UMR 7225 - INSERM U1127 - UPMC UMR S 1127, Hôpital Pitié-Salpétrière, 47, Boulevard de l'Hôpital, 75013, Paris, France.

Introduction: While several theories have highlighted the importance of the noradrenergic system for behavioral flexibility, a number of recent studies have also shown a role for noradrenaline in motivation, particularly in effort processing. Here, we designed a novel sequential cost/benefit decision task to test the causal influence of noradrenaline on these two functions in rhesus monkeys.

Methods: We manipulated noradrenaline using clonidine, an alpha-2 noradrenergic receptor agonist, which reduces central noradrenaline levels and examined how this manipulation influenced performance on the task.

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Noradrenaline and dopamine neurons in the reward/effort trade-off: a direct electrophysiological comparison in behaving monkeys.

J Neurosci

May 2015

Motivation, Brain, and Behavior Team, Institut du Cerveau et de la Moelle Épinière, 75013 Paris, France,

Odor signals in wild western lowland gorillas: an involuntary and extra-group communication hypothesis.

Physiol Behav

June 2015

Team Motivation, Brain & Behavior, Institut du Cerveau et de la Moelle épinière (ICM), Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France. Electronic address:

Odors constitute one of the most ancient ways of communication among animals. Whereas the key role of olfactory communication is well established in insects or rodents, its contribution to primate behavior remains very speculative. In a recent report, Klailova and Lee [1] studied the variations of intensity of the typical steroid musk odor produced by wild adult male gorilla silverbacks during encounters with opponents from other social units (lone males or other groups).

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Sensitivity of locus ceruleus neurons to reward value for goal-directed actions.

J Neurosci

March 2015

Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, and.

The noradrenergic nucleus locus ceruleus (LC) is associated classically with arousal and attention. Recent data suggest that it might also play a role in motivation. To study how LC neuronal responses are related to motivational intensity, we recorded 121 single neurons from two monkeys while reward size (one, two, or four drops) and the manner of obtaining reward (passive vs active) were both manipulated.

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Assessing value representation in animals.

J Physiol Paris

February 2016

Team Motivation, Brain and Behavior, Institut du Cerveau et de la Moelle, Hôpital de la Pitié Salpêtrière Paris, France. Electronic address:

Among all factors modulating our motivation to perform a given action, the ability to represent its outcome is clearly the most determining. Representation of outcomes, rewards in particular, and how they guide behavior, have sparked much research. Both practically and theoretically, understanding the relationship between the representation of outcome value and the organization of goal directed behavior implies that these two processes can be assessed independently.

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