Association of circulating adiponectin and leptin levels with the risk of diabetic peripheral neuropathy.

Background: Adipokines have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and related complications due to their roles in metabolic regulation and inflammation. However, the relationship between these adipokines and diabetic peripheral neuropathy (DPN) remains unclear.

Methods: A case-control study was performed with 198 patients with DPN and 205 T2DM patients without DPN from the Endocrinology Department at the Second Affiliated Hospital of Hainan Medical University.

Development of a urine-based metabolomics approach for multi-cancer screening and tumor origin prediction.

Background: Cancer remains a leading cause of mortality worldwide. A non-invasive screening solution was required for early diagnosis of cancer. Multi-cancer early detection (MCED) tests have been considered to address the challenge by simultaneously identifying multiple types of cancer within a single test using minimally invasive blood samples.

Self-Management of Kidney Transplant Recipients Research: A Comprehensive Bibliometric Analysis.

Objective: This study analyzes research trends in self-management among kidney transplant recipients to inform future directions.

Methods: Bibliometric analysis was performed on 444 English articles related to self-management of kidney transplant recipients in the Core Collection of Web of Science and Scopus databases using COOC 12.8, R software, Microsoft Excel 2019, VOSviewer, and CiteSpace, with a focus on citation ranking, publication year, journal, country, organization, author, impact factor, and keywords.

The mediating effects of death reflection on death literacy and death anxiety among Chinese nurses: a cross-sectional study.

The purpose of this study was to investigate the mediating effect of death reflection on death literacy and death anxiety in clinical nurses. A sample of 2,882 nurses in China were selected by convenience sampling. A socio-demographic questionnaire, a death literacy scale, a death reflection scale, and a death anxiety scale were used to investigate.

MicroRNA-668 alleviates renal fibrosis through PPARα/PGC-1α pathway.

Background: The involvement of microRNA-668 (miR-668) in the onset and progression of renal fibrosis remains unclear. To this end, we aimed to explore the relevant mechanism of miR-668 in renal fibrosis.

Methods: C57BL/6 J male mice were randomly divided into sham-operated, unilateral ureteral obstruction (UUO), and UUO-fenofibrate groups.

The relationship between serum uric acid and homocysteine is influenced by kidney function.

Background And Aim: Prior research has established a relationship between homocysteine (Hcy) and serum uric acid (SUA) levels; however, the precise mechanisms underlying this association remain unclear. The objective of this research was to explore the correlation between SUA and Hcy and to evaluate the possible role of kidney function as a mediator in the connection between SUA and Hcy.

Methods And Results: Consecutive enrollment of 16870 participants aged 20-60 years was conducted at the Third Xiangya Hospital of Central South University.

Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway.

Background: Increased reactive oxygen species (ROS) are involved in the pathological process of dry eye disease. Our previous results suggested that norepinephrine (NE) has a protective effect on dry eye.

Purpose: This study explored the potential therapeutic role and underlying mechanisms of NE in benzalkonium chloride (BAC)-induced dry eye disease.

Effects of fish oil supplementation on bone turnover markers in depression: a pilot study.

Background And Objective: There is a close correlation between bone loss, depression, and antidepressants. N-3 PUFA supplementation has been considered an effective add-on therapeutic approach in ameliorating bone loss and relieving depression. However, the adjunctive effect of n-3 PUFA on bone metabolism in participants with depression is still unknown.

SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β.

Background: Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease characterized by a heterogeneous tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) constitute the major innate immune population in the TIME where they facilitate crucial regulatory processes that participate in malignant tumor progression. SPP1 + macrophages (SPP1 + Macs) are found in many cancers, but their effects on HNSCC remain unknown.

Elevated Activity in Left Homologous Music Circuits Is Inhibitory for Music Perception but Mediated by Structure-Function Coupling.

Aims: Previous studies suggested that structural and functional connectivity of right frontotemporal circuits associate with music perception. Emerging evidences demonstrated that structure-function coupling is important for cognition and may allow for a more sensitive investigation of brain-behavior association, while we know little about the relationship between structure-function coupling and music perception.

Methods: We collected multimodal neuroimaging data from 106 participants and measured their music perception by Montreal Battery of Evaluation of Amusia (MBEA).

Comprehensive analysis identifies a lactylation-related signature for predicting prognosis and guiding therapies in colon adenocarcinoma.

Purpose: This study aimed to identify a lactylation-related gene signature for predicting prognosis and guiding therapies in colon adenocarcinoma (COAD). We seek to address the challenges in COAD prognostication due to tumor heterogeneity and variable treatment responses.

Methods: The study employed integrative bioinformatics analyses on multi-omics data from public databases, including gene expression profiles, clinical data, and lactylation-related genes (LRGs).

Occurrence and associated factors of self-reported medical errors among Chinese physicians and nurses: a cross-sectional survey.

Background: Medical errors (MEs) significantly threaten patient safety globally. This study aimed to explore multidimensional factors associated with self-reported MEs among Chinese physicians and nurses.

Methods: A cross-sectional online survey using snowball sampling collected 7197 valid responses from Chinese physicians and nurses between October 2020 and April 2022.

The predictive value of estimated glucose disposal rate for all-cause and cardiovascular mortality in the US non-diabetic population aged ≥60 years: A population-based cohort study.

Aims: This study seeks to evaluate the prognostic significance of eGDR in predicting mortality outcomes within non-diabetic older adults.

Methods: 8131 non-diabetic participants aged ≥60 years from the National Health and Nutrition Examination Survey (2001-2018) was included in this study. eGDR was calculated as: eGDR (mg/kg/min) = 21.

Itraconazole Reversing Acquired Resistance to Osimertinib in NSCLC by Inhibiting the SHH/DUSP13B/p-STAT3 Axis.

There is an urgent necessity to devise efficient tactics to tackle the inevitable development of resistance to osimertinib, which is a third-generation epidermal growth factor receptor (EGFR) inhibitor used in treating EGFR-mutant nonsmall cell lung cancer (NSCLC). This study demonstrates that combining itraconazole with osimertinib synergistically reduces the proliferation and migration, enhances the apoptosis of osimertinib-resistant cells, and effectively inhibits the growth of osimertinib-resistant tumors. Mechanistically, itraconazole combined with osimertinib promotes the proteasomal degradation of sonic hedgehog (SHH), resulting in inactivation of the SHH/Dual-specificity phosphatase 13B (DUSP13B)/p-STAT3 and Hedgehog pathways, suppressing Myc proto-oncogene protein (c-Myc).

A rapid approach based on empirical formulas and graph traversal algorithms to automatic generation of fragrance formulas.

This article proposes a novel approach for improving the efficiency of fragrance designing and the accuracy of automatic fragrance formula creation based on empirical fragrance formulas and graph traversal algorithms. By effectively extracting the composition information and further analyzing the combination of fragrance materials in 210 fragrance formulas, a relational network model was constructed in the form of a graph to illustrate the relationship between the ingredients used in the formulas. Additionally, a fragrance ingredients information database of 344 common ingredients was constructed and used as a reference for perfumers when setting algorithmic constraints based on their experience.

Association between personality and cognitive bias in adults with and without depression.

Background: Cognitive bias plays a crucial role in the onset and persistence of depression. Research has established a link between personality traits and cognitive bias; however, most of them focused on the general population, overlooking individuals with depression. We aim to explore the relationship between personality and cognitive bias in patients with major depressive disorder (MDD) and compare the results with healthy controls (HCs) to identify potential patterns.

It is time to reevaluate the lard in glucose homeostasis and diabetes pathogenesis.

Most modern dietary guidelines recommend limiting lard and animal fats due to their potential link to metabolic diseases. Nevertheless, emerging evidence suggests that lard may not significantly contribute to diabetes and that moderate lard intake could even benefit lipid metabolism. This commentary suggests a reevaluation of lard’s classification as a “bad actor” in the context of diabetes, urging colleagues to give greater consideration to and empirically validate this intriguing hypothesis.

Bilirubin nanoparticles modulate Treg/Th17 cells and functional metabolism of gut microbiota to inhibit lung adenocarcinoma.

The level of serum bilirubin is associated with the incidence of lung cancer in both smokers and non-smokers, but the specific mechanism is unknown. Bilirubin nanoparticles (BRNPs) were synthesized to explore the effects on Treg/Th17 immunity and gut microbiota in Lewis Lung Carcinoma (LLC) mice, to provide insights for the treatment of lung adenocarcinoma. 10 μg/mL BRNPs promoted apoptosis of A549, NCI-H1299 and LLC cells.

Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms.

Antibiotic resistance by methicillin-resistant Staphylococcus aureus (MRSA) is an urgent threat to human health. The biofilm and persister cells formation ability of MRSA and Staphylococcus epidermidis often companied with extremely high antimicrobial resistance. Pinaverium bromide (PVB) is an antispasmodic compound mainly used for irritable bowel syndrome.

Scoliosis in Rett syndrome: a comparative analysis of postoperative complications.

Rett syndrome, a neurodevelopmental disorder primarily affecting females, presents unique challenges in managing associated scoliosis. This study aims to evaluate the efficacy and challenges of posterior spinal fusion (PSF) in Rett syndrome patients by analyzing postoperative complications. A retrospective cohort study was conducted using a large national database.