2 results match your criteria: "nr 1 Universitatii Street[Affiliation]"
Cognition, Statins, and Cholesterol in Elderly Ischemic Stroke Patients: A Neurologist's Perspective.
Medicina (Kaunas)
June 2021
Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, nr 1 Universitatii Street, 410087 Oradea, Romania.
The efficacy of hydroxy methyl glutaryl-coenzyme A reductase inhibitors (statins) in reducing the incidence of cardiovascular events pushed the target LDL-cholesterol (LDL-C) levels lower and lower in successive guidelines despite signals regarding potential cognitive side effects. We evaluated the relationship between cognitive impairment and LDL-C levels in elderly ischemic stroke patients. 29 ischemic stroke patients aged 65 and above with LDL-C levels ≤70 mg/dL, classified according to the TOAST criteria, underwent detailed neuropsychological testing comprising the MMSE test, Montreal Cognitive Assessment (MoCA) and Addenbrooke's Cognitive Evaluation (ACE-III) test.
View Article and Find Full Text PDFThe Role of Natural Antioxidants in the Prevention of Dementia-Where Do We Stand and Future Perspectives.
Nutrients
January 2021
Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, nr 1 Universitatii Street, 410087 Oradea, Romania.
Article Synopsis
- Dementia, particularly Alzheimer's disease, significantly strains global healthcare due to its growing prevalence and related costs.
- Oxidative stress plays a key role in the development of dementia, but current drug treatments targeting specific pathways have not been very effective.
- Natural antioxidants may offer a multi-targeted approach to combatting dementia, although challenges like bioavailability and optimal dosing in human trials still need to be addressed.