1 results match your criteria: "niversity of Michigan Medical Center[Affiliation]"
Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice.
Arterioscler Thromb Vasc Biol
August 2005
Division of Cardiovascular Medicine, Department of Internal Medicine, niversity of Michigan Medical Center, Ann Arbor, MI, USA.
Objective: The direct role of leptin in vascular disease remains controversial. The objective of this study was to examine the effects of leptin treatment on atherosclerosis and thrombosis in atherosclerotic-prone mice.
Methods And Results: Sixteen-week-old, male apolipoprotein E-deficient mice were treated with injections of recombinant leptin (125 microg per day IP; n=10) or vehicle (n=10) for 4 weeks.