9,631 results match your criteria: "l'Hospitalet[Affiliation]"
Efficacy of bone morphogenetic protein in comparison with autogenous bone in regeneration of ameloblastoma bone defects. A systematic review.
Med Oral Patol Oral Cir Bucal
November 2024
School of Medicine and Health Sciences Campus de Bellvitge. University of Barcelona C/ Feixa Llarga s/n; Pavelló Govern, 2ª planta, Despatx 2.9 08907 - L'Hospitalet de Llobregat (Barcelona), Spain
Article Synopsis
- The study aimed to compare the effectiveness of bone morphogenetic proteins (BMPs) and autogenous bone grafts (ABGs) in regenerating bone defects caused by ameloblastoma.
- Nine studies were analyzed, including a total of 229 participants, with a notable agreement (98.21%) between the researchers assessing the studies.
- Results indicated that BMPs showed a higher success rate in bone regeneration compared to ABGs, despite some limitations in the existing research.
Prevalence and risk factors of chronic oral complications in head and neck cancer therapies: A retrospective study.
Med Oral Patol Oral Cir Bucal
November 2024
School of Medicine and Health Sciences Campus de Bellvitge. University of Barcelona C/ Feixa Llarga s/n; Pavelló Govern 08907, L'Hospitalet de Llobregat, Barcelona, Spain
Article Synopsis
- The study investigates chronic oral complications in patients with head and neck cancer undergoing various oncological therapies, aiming to identify prevalence rates and risk indicators related to the patient and treatment.
- The research involved analyzing medical histories of patients treated at the Dental Hospital of the University of Barcelona, collecting data on demographics, health status, and oral complications to understand their relationships with cancer treatment.
- Findings revealed a high prevalence of chronic oral complications (92.57%), with dental disease and hyposalivation being the most common, highlighting the need for effective monitoring and preventive care in these patients.
Article Synopsis
- Liquid biopsy (LB) with FoundationOne Liquid CDx (F1L CDx) offers a non-invasive way to detect genetic changes in advanced non-small cell lung cancer (NSCLC) patients when tissue biopsies aren't possible, and this study assesses its cost-effectiveness in Spain.
- In a model evaluating 1,000 patients, F1L CDx identified 386 alterations, enabling targeted treatments and yielding significant health benefits compared to traditional non-molecular diagnosis, evidenced by an additional 383.95 life years (LYs) and 305.94 quality-adjusted life years (QALYs) despite a higher overall cost of €2,898,308.
- The analysis concludes that F1L CDx
Mechanical circulatory support in cardiogenic shock patients.
Med Intensiva (Engl Ed)
December 2024
Department of Intensive Care Medicine, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
Article Synopsis
- Cardiogenic shock (CS) is a serious medical condition that requires quick intervention to address its cause and provide support for blood circulation.* -
- Mechanical circulatory support (MCS) is often used for patients with severe CS to replace ineffective heart function and prevent multiple organ failure, with different devices available for short or intermediate durations.* -
- Effective management of patients with MCS involves careful monitoring for complications and following structured protocols for device use and discontinuation.*
Impact of left ventricular unloading on postheart transplantation outcomes in patients bridged with VA-ECMO.
Rev Esp Cardiol (Engl Ed)
October 2024
Servicio de Cardiología, Complejo Hospitalario Universitario de A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Facultad de Ciencias de la Salud, Universidad de A Coruña, A Coruña, Spain.
Article Synopsis
- * A total of 245 patients were analyzed, with 54.3% using mechanical LV unloading techniques, primarily the intra-aortic balloon pump, showing an improved 1-year survival rate of 74.4% compared to 59.8% in those without LV unloading.
- * The findings suggest that preoperative LV unloading is linked to better survival rates after a year post-transplant, with no notable differences in other postoperative complications between groups.
Clinical features, management in the emergency department and mortality of acute heart failure episodes in patients with chronic obstructive pulmonary disease.
Rev Clin Esp (Barc)
December 2024
Servicio de Urgencias, Hospital Clínic Barcelona, IDIBAPS, Universitat de Barcelona, Spain. Electronic address:
Article Synopsis
- The study investigates how patients with chronic obstructive pulmonary disease (COPD) are managed in emergency departments when they present with acute heart failure (AHF), comparing them to AHF patients without COPD.
- It analyzes data from 21,694 AHF patients, focusing on demographics, clinical characteristics, and differences in treatment approaches between the two groups over a ten-year period.
- Findings reveal that COPD patients were younger with more comorbidities, had different triggers and management strategies in emergencies, and exhibited slightly higher in-hospital (8.1%) and 30-day (11.0%) mortality rates compared to non-COPD patients (7.5% and 10.0%, respectively).
Impact of chronic renin-angiotensin-aldosterone inhibitors on short-term outcomes in patients with acute heart failure presenting to the emergency department. A propensity-matched analysis EAHFE cohort.
Int J Cardiol
January 2025
Emergency Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.
Objectives: The aim of the present study was to evaluate the impact of chronic treatment with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) on short-term clinical outcomes after an episode of AHF.
Methods: A secondary analysis of patients included in the EAHFE (Epidemiology of Acute Heart Failure in Emergency Departments) cohort, which includes patients diagnosed with AHF in 45 Spanish Emergency Departments (EDs). The primary outcome was all-cause in-hospital mortality.
Salvage reirradiation for recurrent glioblastoma: a retrospective case series analysis.
Clin Transl Oncol
October 2024
Neurology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Article Synopsis
- This study evaluated the outcomes of 44 patients with recurrent glioblastoma who underwent reirradiation after an initial treatment, finding that median overall survival after the second treatment was 14.9 months.
- The most common reirradiation method used was 35 Gy in 10 fractions, with mild acute side effects and a 40% rate of radiological response; however, many patients also experienced early distant progressions.
- Factors like a Karnofsky index below 70 and smaller recurrence sizes were linked to better overall survival, suggesting reirradiation is a viable option, especially for patients in good health with smaller lesions.
AML typical mutations (CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular.
Blood Adv
January 2025
Grupo Español de Síndromes Mielodisplásicos, Madrid, Spain.
Article Synopsis
- Mutations commonly associated with acute myeloid leukemia (AML) were studied in 127 patients with chronic myelomonocytic leukemia (CMML), revealing varying prevalence rates like CEBPA (7), FLT3 (8), IDH1 (12), IDH2 (26), and NPM1 (11).
- CMML patients with CEBPA, FLT3, and/or NPM1 mutations showed more severe symptoms and higher risk characteristics, indicating they were more frequently linked to the myeloproliferative subtype (MP-CMML).
- The study suggests that these mutations should be included in CMML prognostic models and advocates for treating these patients with AML-type therapies due to their poor
Exploring cultural competence barriers in the primary care sexual and reproductive health centres in Catalonia, Spain: perspectives from immigrant women and healthcare providers.
Int J Equity Health
October 2024
Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Av Gran Via 199-203, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.
Background: Immigrant populations, especially women, continue facing challenges in accessing quality healthcare, particularly sexual and reproductive health services (SRH). Poor cultural competent health systems contribute to communication challenges between immigrant women and healthcare providers perpetuating health disparities. This exploratory study describes these communication barriers from the perspective of Moroccan and Pakistani immigrant women and healthcare providers within the Catalan health system and its implications to ensure an equitable provision of SRH services.
View Article and Find Full Text PDFNeoadjuvant sunitinib plus exemestane in post-menopausal women with hormone receptor-positive/HER2-negative early-stage breast cancer (SUT_EXE-08): a phase I/II trial.
Sci Rep
October 2024
Breast Cancer Unit, Department of Medical Oncology, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.
Article Synopsis
- * Out of 18 postmenopausal women treated, 66% showed an objective response, and common side effects included fatigue and hypertension, but no severe toxicities were reported.
- * The research also highlighted changes in biomarker levels and gene expression after treatment, indicating potential biological impacts of combining antiangiogenic therapy with hormone therapy in this patient population.
Late gadolinium enhancement and outcome of cardiac resynchronization therapy in non-ischemic cardiomyopathy.
Int J Cardiol
January 2025
Cardiology Department, Bellvitge University Hospital, Hospitalet de Llobregat, Barcelona, Spain; Bioheart Group, Cardiovascular, Respiratory and Systemic Diseases and cellular aging Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain. Electronic address:
Article Synopsis
- The study investigates whether cardiac resynchronization therapy with a defibrillator (CRTD) is better than therapy with a pacemaker (CRTP) for patients with non-ischemic cardiomyopathy (NICM) and low risk of arrhythmias.
- It analyzes data from 167 NICM patients, looking for predictors of heart function improvement (echocardiographic response) and serious heart rhythm issues (arrhythmias) over a median follow-up of 63 months.
- Findings reveal that patients without late gadolinium enhancement (LGE) show a much higher response rate to CRT (81% vs. 53%) and no arrhythmic events, suggesting they are ideal candidates for CRTP rather than
Importance: Cardiac surgery-associated acute kidney injury (CSA-AKI) remains a significant problem following cardiopulmonary bypass (CPB). Various strategies are proposed to attenuate CSA-AKI, including extracorporeal blood purification (EBP), but little is known about the effect of EBP through an acrylonitrile-sodium methallylsulfonate/polyethyleneimine membrane during CPB.
Objective: To determine whether the use of an EBP device in a nonemergent cardiac surgery population reduces CSA-AKI after CPB.
Development and Psychometric Properties of the Therapeutic Relationship Assessment Scale-Patient (TRAS-Patient).
Int J Ment Health Nurs
February 2025
CINTESIS@RISE, Nursing School of Porto (ESEP), Porto, Portugal.
The therapeutic relationship plays a crucial role in nursing care for people with mental illness. Adopting a systemic and person-centred approach that considers the individual experiences and needs of the person is paramount. However, no instruments were found in the literature designed to evaluate the nurse-patient therapeutic relationship from the perspective of a person with mental illness.
View Article and Find Full Text PDFTachypnea in response to hypoxemia decreases with age in older patients.
Geriatr Gerontol Int
November 2024
Emergency Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain.
Article Synopsis
- The study aimed to investigate whether older patients (≥65 years) have a diminished tachypneic response to hypoxia, meaning they may not breathe faster in response to low oxygen levels as much as younger patients do.
- Researchers analyzed data from 7126 patients in Spanish emergency departments, measuring peripheral arterial oxygen saturation (SatO2) and respiratory rate (RR) upon arrival, finding significant correlations across all age groups studied.
- Results indicated that as patient age increased, the respiratory rate response to decreasing oxygen levels slowed down, with younger individuals showing a faster increase in breathing rate in response to hypoxia compared to older individuals, particularly those aged ≥90 years.
Drug-induced pancreatitis: study of 38 patients.
Med Clin (Barc)
December 2024
Servicio de Farmacología Clínica, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat (Barcelona), España; Unidad de Farmacología, Departamento de Patología y Terapéutica Experimental, Facultad de Medicina y Ciencias de la Salud, Universidad de Barcelona, L'Hospitalet de Llobregat (Barcelona), España.
Article Synopsis
- Acute pancreatitis (AP) is an inflammatory condition with various causes, including drugs, which account for a small percentage of cases; diagnosing drug-induced AP is often complicated due to a lack of specific symptoms.
- A study conducted at Hospital Universitari de Bellvitge analyzed 38 patients with suspected drug-induced AP from June 2007 to March 2023, revealing that most cases were linked to a single drug, with azathioprine and atorvastatin being the most common culprits.
- The findings suggest that increased awareness and a proposed diagnostic algorithm may improve the identification and management of drug-induced pancreatitis, highlighting the need for drug assessment when diagnosing AP.
Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case-control sets from the European Prospective Investigation into Cancer and Nutrition.
Int J Cancer
March 2025
Cancer Epidemiology Unit, Oxford Population Health, University of Oxford, Oxford, UK.
Article Synopsis
- * No significant associations were found between individual metabolites or patterns and overall prostate cancer risk after adjusting for multiple tests, except for six specific phosphatidylcholines linked to advanced cases diagnosed within 10 years.
- * Two metabolite patterns (1 and 2) showed inverse associations with advanced prostate cancer, while pattern 3 was related to prostate cancer death, indicating that metabolite profiles may change several years before advanced disease is detected.
Huntington Disease Health Related Quality of Life, Function and Well Being: The Patient's Perspective.
Neurol Ther
February 2025
Department of Neurology, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.
Background: Limited information is available on patients' experience living with Huntington's disease (HD). The primary objective of this study was to assess the health-related quality of life and well being of patients with HD.
Methods: A non-interventional, cross-sectional study was conducted in 17 hospitals-based movement disorders units in Spain.
Impact of COVID-19 infection on genitourinary cancer management. SOGUG-COVID-19: A spanish, multicenter, observational study.
Clin Transl Oncol
October 2024
Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), CIBERONC, Madrid, Spain.
Introduction: The COVID-19 pandemic is a great burden worldwide, but its impact on patients with genitourinary cancer (GUC) is poorly characterized. This study aimed to characterize the clinical features and evolution of GUC patients affected by COVID-19 in Spain.
Patients And Methods: SOGUG-COVID-19 was an observational ambispective non-interventional study that recruited patients with SARS-CoV-2 infection who had been treated for GUC in 32 Spanish hospitals.
Maladaptive eating behaviors and health-related quality of life in Spanish children.
Appetite
December 2024
CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain; Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Research Institute, Barcelona, Spain. Electronic address:
Article Synopsis
- * A study involving 690 boys and 681 girls aged 8-10 from Catalonia aimed to explore the effects of external, emotional, and restrained eating on HRQoL over a follow-up period of about 14.65 months.
- * The findings revealed that both external and emotional eating behaviors negatively impacted HRQoL at follow-up, with a composite score of maladaptive eating showing a stronger negative association than individual behaviors.
Bone loss after bariatric surgery is observed mainly in the hip trabecular compartment and after hypoabsorptive techniques.
Bone
January 2025
Endocrinology and Nutrition Department, Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; CIBER Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain.
We evaluated the impact of bariatric surgery on bone mineral density (BMD) and microarchitecture over one year using dual-energy X-ray absorptiometry (DXA), the trabecular bone score (TBS), and 3D-DXA to assess changes after different surgical techniques. This prospective, single-center study of 153 patients with severe obesity contrasts the effects on bone health of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and duodenal switch/single anastomosis duodeno-ileostomy with sleeve gastrectomy (DS/SADIS). To our knowledge, this is the first study to evaluate patients undergoing DS/SADIS and to incorporate 3D-DXA analysis in the assessment of bone loss.
View Article and Find Full Text PDFDoes geographic availability of alcohol influence drinking in adolescents? A systematic review of literature associations.
Health Place
November 2024
Public Health and Epidemiology Research Group, School of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain; Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY, 10027, United States; Tobacco Control Research Group, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Background: The role of alcohol geographic availability in influencing adolescent drinking has been debated. However, clear literature consensus has not been reached.
Objective: To provide a systematic review of the associations between geographic availability of alcohol outlets measured through different methodologies and drinking outcomes in adolescents.
Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis.
Eur J Prev Cardiol
October 2024
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Article Synopsis
- The study investigated the links between saturated and unsaturated fatty acids and cardiovascular disease (CVD), focusing on conditions like coronary heart disease (CHD) and stroke in a large group of participants.
- Results showed that higher levels of saturated fatty acids were linked to increased CVD risks, with specific subtypes having varying effects on CHD and stroke.
- Conversely, higher concentrations of certain polyunsaturated fatty acids (both n-3 and n-6 types) were associated with lower risks of CHD and stroke, suggesting dietary fats play a significant role in cardiovascular health.
Bioinformatic analysis of molecular characteristics and oncogenic features of CARD14 in human cancer.
Sci Rep
October 2024
Immunology Unit, Department of Pathology and Experimental Therapy, School of Medicine, Universitat de Barcelona, Barcelona, 08007, Spain.
Article Synopsis
- CARD14 is a protein linked to inflammatory skin diseases and serves as a scaffold to activate NF-KB, with new research suggesting it may also influence cancer development.* -
- Analysis of TCGA tumor data revealed increased CARD14 expression in various cancers, correlating with better patient survival rates in sarcoma, lung, cervix, and head and neck cancers.* -
- The study indicates that CARD14 not only relates to immune cell infiltration, particularly neutrophils, but also plays a role in epithelial development, suggesting its potential as a prognostic biomarker in cancer.*
Novel risk loci for COVID-19 hospitalization among admixed American populations.
Elife
October 2024
CIBERER, ISCIII, Madrid, Spain.
Article Synopsis
- The study investigates the genetic factors linked to severe COVID-19, specifically focusing on hospitalized cases in admixed Americans.
- Researchers conducted the largest genome-wide association study (GWAS) for COVID-19 hospitalization in this population, identifying four significant genetic associations, including two novel loci found in Latin Americans.
- The findings highlight the importance of including diverse populations in genomic research, aiming to improve understanding of genetic risks associated with COVID-19 across different ethnic groups.